Hypnotherapy in Pain Management for Cancer Patients: A Systematic Review
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Page: 2512-2521
Abstract
Cancer remains one of the leading causes of mortality worldwide, with over 20 million newly diagnosed cases and nearly 10 million deaths globally, as reported by the International Agency for Research on Cancer (IARC) in 2020. In Indonesia, the incidence reached 408,661 new cases with 242,988 cancer-related deaths recorded in 2022. This growing burden has resulted in numerous clinical implications, with pain identified as the most frequently reported symptom among cancer patients, significantly impairing their quality of life. Among emerging approaches in pain management, non-pharmacological interventions such as hypnotherapy have gained attention due to their potential to reduce pain intensity without inducing serious adverse effects. This systematic review aims to evaluate the effectiveness of hypnosis therapy in managing cancer-related pain by analyzing six selected studies sourced from five international databases: ScienceDirect, EBSCO, PubMed, ProQuest, and Sage Journals. All included studies met the eligibility criteria, comprising randomized controlled trials (RCTs) and one meta-analysis, published within the last ten years. Five out of the six studies demonstrated that hypnosis interventions were effective in reducing pain intensity, while one study showed no statistically significant effect. Additionally, several studies explored integrative approaches combining hypnosis with complementary modalities such as music therapy and cognitive behavioral therapy. The findings of this review suggest that hypnotherapy serves as a promising complementary intervention to support effective pain management in oncology care. Further research employing more rigorous methodologies and larger sample sizes is recommended to strengthen the evidence base regarding its clinical utility.
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References
Deo SVS, Sharma J, Kumar S. GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists. Ann Surg Oncol 2022;29:6497–500. https://doi.org/10.1245/s10434-022-12151-6. DOI: https://doi.org/10.1245/s10434-022-12151-6
Sharma R, Aashima, Nanda M, Fronterre C, Sewagudde P, Ssentongo AE, et al. Mapping Cancer in Africa: A Comprehensive and Comparable Characterization of 34 Cancer Types Using Estimates From GLOBOCAN 2020. Front Public Heal 2022;10:1–14. https://doi.org/10.3389/fpubh.2022.839835. DOI: https://doi.org/10.3389/fpubh.2022.839835
Anissa M, Artiwi Putri C, Mahatma G. Gambaran Tingkat Depresi Pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Tanjung Pinang Tahun 2022. Sci J 2023;2:191–9. https://doi.org/10.56260/sciena.v2i5.103. DOI: https://doi.org/10.56260/sciena.v2i5.103
Batbual B. Hypnosis hypnobirthing nyeri persalinan dan berbagai metode penanganannya. Yogyakarta Gosyen Publ 2010.
Abdurahman A, Bandiara R, Supriyadi R. Mon-055 The Growing Burden Of End Stage Renal Disease In Indonesia: Ten Years of The Indonesian Renal Registry Reports. Kidney Int Reports 2019;4. https://doi.org/10.1016/j.ekir.2019.05.843. DOI: https://doi.org/10.1016/j.ekir.2019.05.843
Crosby J.; Stidston, C.; McGinley, S.; Powell, R. J. AC. D. Aromatherapy Massage for Breast Cancer Patients: A Randomized Controlled Trial. J Nurs Women’s Heal 2018;3. DOI: https://doi.org/10.29011/2577-1450.100044
Astuti BD, Sunarti, Suryani D. Disfungsi Yodium Pada Ibu Hamil. J Mandalika Lit 2024;5(4):609–15.
Mendoza ME, Capafons A, Gralow JR, Syrjala KL, Suárez-Rodríguez JM, Fann JR, et al. Randomized controlled trial of the Valencia model of waking hypnosis plus CBT for pain, fatigue, and sleep management in patients with cancer and cancer survivors. Psychooncology 2017;26:1832–8. https://doi.org/10.1002/pon.4232.
Hernández. Clinical Hypnosis For Pain Reduction in Breast Cancer Mastectomy 2022.
Deng G. Integrative medicine therapies for pain management in cancer patient. Cancer J 2021;25:343–8. https://doi.org/10.1097/PPO.0000000000000399. DOI: https://doi.org/10.1097/PPO.0000000000000399
Drazich BF, Anokye D, Zhu S, Teleb J, Galik E, Colloca L, et al. Motivating older adults through immersive virtual exercise (MOTIVE): A randomized pilot study. Geriatr Nurs (Minneap) 2023;54:229–36. https://doi.org/10.1016/j.gerinurse.2023.09.019. DOI: https://doi.org/10.1016/j.gerinurse.2023.09.019
Etienne R, Laurent M, Henry A, Bioy A, Salleron J, Schohn CH, et al. Interest of a standardized hypnotic message for the reduction of pain and anxiety in cancer patients treated by capsaicin patch for neuropathic pain: a randomized controlled trial. BMC Complement Med Ther 2021;21:1–8. https://doi.org/10.1186/s12906-021-03329-8. DOI: https://doi.org/10.1186/s12906-021-03329-8
Mendoza ME. Randomized controlled trial of the Valencia model of waking hypnosis plus CBT for pain, and sleep management in patient with cancer and cancer survivors. Psychooncology 2017;26:1832–8. DOI: https://doi.org/10.1002/pon.4232
Grégoire M.-E.; Vanhaudenhuyse, A.; Charland-Verville, V.; Jerusalem, G.; Willems, S.; Bragard, I. C. F. Exploratory Controlled Study of the Impact of a Hypnosis-Based Intervention on the Couple’s Communication and Coping in the Context of Cancer. Int J Clin Exp Hypn 2021;69:261–76. DOI: https://doi.org/10.1080/00207144.2021.1878897
Bahçaci U, Uysal SA, Iyigün ZE, Ordu Ç, Soybir GR, Ozmen V. Progressive relaxation training in patients with breast cancer receiving aromatase inhibitor therapy-randomized controlled trial. PLoS One 2024;19:1–12. https://doi.org/10.1371/journal.pone.0301020. DOI: https://doi.org/10.22541/au.162463770.05376828/v2
De Paolis G. The effectiveness of progressive muscle relaxation and interactive guided imagery as a pain-reducing intervention in advanced cancer patients: A multicentre randomised controlled non- pharmacological trial. Complement Ther Clin Pract 2018.
Thompson T, Terhune DB, Oram C, Sharangparni J, Rouf R, Solmi M, et al. The effectiveness of hypnosis for pain relief: A systematic review and meta-analysis of 85 controlled experimental trials. Neurosci Biobehav Rev 2019;99:298–310. DOI: https://doi.org/10.1016/j.neubiorev.2019.02.013
De Paolis G, Naccarato A, Cibelli F, D’Alete A, Mastroianni C, Surdo L, et al. The effectiveness of progressive muscle relaxation and interactive guided imagery as a pain-reducing intervention in advanced cancer patients: A multicentre randomised controlled non-pharmacological trial. Complement Ther Clin Pract 2019;34:280–7. https://doi.org/10.1016/j.ctcp.2018.12.014. DOI: https://doi.org/10.1016/j.ctcp.2018.12.014
Deer S.; Falowski, S. M.; Huntoon, M. A.; Staats, P. S.; Cassar, I. R.; Boggs, J. W. TR. E. Peripherally induced reconditioning of the central nervous system: a proposed mechanistic theory for sustained relief of chronic pain with percutaneous peripheral nerve stimulation. J Pain Res 2021:721–36. DOI: https://doi.org/10.2147/JPR.S297091
Trujillo-Rodriguez D, Faymonville ME, Vanhaudenhuyse A, Demertzi A. Hypnosis for cingulate-mediated analgesia and disease treatment. Handb. Clin. Neurol., vol. 166, 2019, p. 327–39. DOI: https://doi.org/10.1016/B978-0-444-64196-0.00018-2
Halsband U, Wolf TG. Functional Changes in Brain Activity After Hypnosis: Neurobiological Mechanisms and Application to Patients with a Specific Phobia—Limitations and Future Directions. Int J Clin Exp Hypn 2019;67:449–74. https://doi.org/10.1080/00207144.2019.1650551. DOI: https://doi.org/10.1080/00207144.2019.1650551
Milling LS, Valentine KE, LoStimolo LM, Nett AM, McCarley HS. Hypnosis and the Alleviation of Clinical Pain: A Comprehensive Meta-Analysis. Int J Clin Exp Hypn 2021;69:297–322. https://doi.org/10.1080/00207144.2021.1920330. DOI: https://doi.org/10.1080/00207144.2021.1920330
Grégoire H.; Bragard, I.; Delevallez, F.; Merckaert, I.; Razavi, D.; Waltregny, D.; Faymonville, M.-E.; Vanhaudenhuyse, A. C. N. Efficacy of a hypnosis-based intervention to improve well-being during cancer: a comparison between prostate and breast cancer patients. BMC Cancer 2018;18:677. DOI: https://doi.org/10.1186/s12885-018-4607-z
Pagliusi M, Gomes F V. The Role of The Rostral Ventromedial Medulla in Stress Responses. Brain Sci 2023;13:776. https://doi.org/10.3390/brainsci13050776. DOI: https://doi.org/10.3390/brainsci13050776
Leo DG, Keller SS, Proietti R. “Close your eyes and relax”: the role of hypnosis in reducing anxiety, and its implications for the prevention of cardiovascular diseases. Front Psychol 2024;15. https://doi.org/10.3389/fpsyg.2024.1411835. DOI: https://doi.org/10.3389/fpsyg.2024.1411835