Main Article Content

Nur Basmalah
Nayla Nur Azkia Hariadi
Munir Alinu Mulki

Page: 1309-1317

Abstract

Hydroquinone is a compound that is often used in cosmetic products because of its ability to brighten the skin by inhibiting melanin production. However, its use can cause dangerous side effects such as irritation, hyperpigmentation and the risk of cancer, so its use in cosmetics has been limited by BPOM. High Performance Liquid Chromatography (HPLC) is an analytical method commonly used to detect hydroquinone in cosmetic preparations because of its sensitivity and ability to separate compounds with high complexity. This article is a literature review which aims to determine the effect of mobile phase comparison on hydroquinone analysis using the HPLC method. The research results show that selecting the right mobile phase is very important to guarantee accurate, precise and efficient analysis results. The combination of a polarity-based mobile phase that matches the properties of hydroquinone provides good resolution, high sensitivity, and optimal retention time. This research is expected to provide guidance in optimizing the HPLC method for hydroquinone analysis, and is expected to support cosmetic safety monitoring.

Downloads

Download data is not yet available.

Article Details

How to Cite
Basmalah, N., Hariadi , N. N. A., & Mulki , M. A. (2025). Article Review: The Effect of Mobile Phase Ratio in the Analysis of Hydroquinone Compounds in Cosmetic Preparations Using the High Performance Liquid Chromatography (HPLC). Journal of Pharmaceutical and Sciences, 8(2), 1309–1317. https://doi.org/10.36490/journal-jps.com.v8i2.687
Section
Review Article

References

Arifiyana, D., dkk. Analisis Kuantitatif Hidrokuinon pada Produk Kosmetik Krim Pemutih yang Beredar di Wilayah Surabaya Pusat dan Surabaya Utara dengan Metode Spektrofotometri UV-Vis. Akta Kimindo. 2019;4(2):107-117. doi: http://dx.doi.org/10.12962/j25493736.v4i2.5532 DOI: https://doi.org/10.12962/j25493736.v4i2.5532

Lestari, W. R., & Dian, P. Analisis Hidrokuinon pada Bleaching Cream yang Dijual secara Online dan Tidak Memiliki Izin Edar dari BPOM. Media Farmasi. 2018;15(1):43-51. doi: https://doi.org/10.12928/mf.v15i1.12357 DOI: https://doi.org/10.12928/mf.v15i1.12357

BPOM. Persyaratan Teknis Bahan Kosmetika. Jakarta;2019.

Putri, A. R., & Wahyudiani, M. N. Analisis Kadar Hidrokuinon Pada Krim Pemutih Yang Beredar Di Toko Online Dengan Metode Spektrofotometri. Jurnal Sosial dan Sains. 2021;1(11):1464,1471. doi: https://doi.org/10.59188/jurnalsosains.v1i11.258 DOI: https://doi.org/10.59188/jurnalsosains.v1i11.258

Sende, I. F., dkk. Peredaran Kosmetik Pemutih Ilegal di Indonesia dan Upaya Penanggulangannya, Eruditio. 2020;1(1):48-62. doi: https://doi.org/10.54384/eruditio.v1i1.30 DOI: https://doi.org/10.54384/eruditio.v1i1.30

Suprianto dkk. Aplikasi Metode Penetapan Kadar Rutin Parasetamol PT. Kimia Farma, Tbk Secara HPLC pada Sediaan Tablet Generik dan Bermerek di Medan, Jurnal Indah Sains & Klinis. 2020;1(1):1-5. doi: 10.52622/9abdjn64 DOI: https://doi.org/10.52622/jisk.v1i1.1

Fertiasari, R., dkk. Analisis Hidrokuinon pada Kosmetik Cair Menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Media Ilmiah Kesehatan Indonesia. 2023;1(1):6-11. doi: https://doi.org/10.58184/miki.v1i1.85 DOI: https://doi.org/10.58184/miki.v1i1.85

Hirjani, dkk. Prediction of High Performance Liquid Chromatography Retention Time for Some Organic Compounds Based on Ab initio QSPR Study. Acta. Chim. Asiana. 2018;1(1):24-29. doi: https://doi.org/10.29303/aca.v1i1.6 DOI: https://doi.org/10.29303/aca.v1i1.6

Rosydiati, dan Ela K. S. Karakterisasi Puncak Kromatogram Dalam High Performance Liquid Chromatography (HPLC) Terhadap Perbedaan Fase Gerak, Laju Alir, Dan Penambahan Asam Dalam Analisis Indole Acetic Acid (IAA). Kandaga. 2019;1(2):65-73. doi: https://doi.org/10.24198/kandaga.v1i2.25056.g12831

Aggraini, Y. D. dkk. Analisis Kadar Hidrokuinon dan Asam Kojic Dalam Tiga Merek Dagang Body Lotion Menggunakan Kromatografi Cair Kinerja Tinggi. Jurnal Ilmiah Sains. 2023;23(1):20-30. doi: https://doi.org/10.35799/jis.v23i1,45703

Nasiroh, dkk. Identifikasi Kadar Hidrokuinon Pada Krim Pemutih Yang Beredar Di Marketplace. 2024;4(2):250-258. doi: 10.33859/jpcs.v4i2 DOI: https://doi.org/10.33859/jpcs.v4i2.596

Maggadani, B.P., dkk. (2019). Simultaneous Identification And Quantification Of Hydroquinone, Tretinoin And Betamethasone In Cosmetic Products By Isocratic Reversed Phase High Performance Liquid Chromatography. International Journal of Applied Pharmaceutics. 2019;11(3):181-185. doi: http://dx.doi.org/10.22159/ijap.2019v11i3.32297 DOI: https://doi.org/10.22159/ijap.2019v11i3.32297

Rovira, F.G. Development and validation of a new RP-HPLC method for the simultaneous determination of hydroquinone, kojic acid, octinoxate, avobenzone, BHA dan BHT in skin-whitening cream. Analytical Methods. 2016;8:1170-1180. doi: 10.1039/C5AY02207J DOI: https://doi.org/10.1039/C5AY02207J

Eradati, N., dkk. Optimization of cleaning and analytical method for determination of arbutin, hydroquinone and kojic acid in cosmetic products. J. Med. Plants. 2021;20(77):50-59. doi: 10.29252/jmp.20.77.50 DOI: https://doi.org/10.52547/jmp.20.77.50

Wang, Y.H. dk. Quantitative Determination of α-Arbutin, β-Arbutin, Kojic Acid, Nicotinamide, Hydroquinone, Resorcinol, 4-Methoxyphenol, 4-Ethoxyphenol, and Ascorbic Acid from Skin Whitening Products by HPLC-UV. Journal of AOAC International. 2015;98(1):5-12. doi: 10.5740/jaoacint.14-123 DOI: https://doi.org/10.5740/jaoacint.14-123

Sheliya, K dkk. Development and validation of analytical method for simultaneous estimation of mometasone furoate, hydroquinone and tretinoin in topical formulation by RP-HPLC. Journal of Chemical and Pharmaceutical Research. 2014;6(4):934-940.

Rahmayuni, E. dkk. Development and Validation Method for Simultaneous Analysis of Retinoic Acid, Hydroquinone and Corticosteroid in Cream Formula by High-Performance Liquid Chromatography. Journal of Applied Pharmaceutical Science. 2018;8(9):87-92. doi: 10.7324/JAPS.2018.8913 DOI: https://doi.org/10.7324/JAPS.2018.8913

Jamal, M. K. A.dan Azza A.G. Development And Validation Of Analytical Spectrophotometric And Rp-Hplc Methods For The Simultaneous Estimation Of Hydroquinone, Hydrocortisone And Tretinoin Ternary Mixture In Topical Formulation. International Journal of Pharmacy and Pharmaceutical Sciences. 2019;11(11):10-16. doi: http://dx.doi.org/10.22159/ijpps.2019v11i11.35188 DOI: https://doi.org/10.22159/ijpps.2019v11i11.35188

Zukepli, N.W.M. dkk. Assessment On Hyroquinone In Selected Cosmetic Cream And Toner Via High Performance Liquid Chromatography And Ultra-Violet Visible Detector Spectrometry. Malaysian Journal of Analytical Sciences. 2015;19(4), 824-830.

Prihasti, N. D. P., Mulki, M. A., & Hidayat, M. N. N. Narrative Review: Parameter dalam Metode Analisis Untuk Identifikasi Rhodamin B dalam Lipstik. Jurnal Sehat Mandir. 2024;19(1):271-284.

Amin, S., Amir, M., & Slamet, I. Kromatografi Cair Kinerja Tinggi Untuk Analisis Senyawa Diuretik yang Disalahgunakan Sebagai Doping Dalam Urin. Jurnal Sains Keolahragaan & Kesehatan, 20161(2):34-41. doi: https://doi.org/10.5614/jskk.2016.1.2.1 DOI: https://doi.org/10.5614/jskk.2016.1.2.1

Angraini, N., & Desmaniar, P. Optimasi Penggunaan High Perbformance Liquid Chromatography (HPLC) untuk Analisis Asam Askorbat Guna Menunjang Kegiatan Praktikum Bioteknologi Kelautan. Jurnal Penelitian Sains. 2020;22(2):69-75. doi: https://doi.org/10.56064/jps.v22i2.583 DOI: https://doi.org/10.56064/jps.v22i2.583

Fudjayanti, S., & Farendina, S. Tinjauan Pustaka Metode Analisis Senyawa Hidrokuinon dalam Sediaan Krim. Jurnal Riset Farmasi. 2022;2(2):138-144. doi: https://doi.org/10.29313/jrf.v2i2.1483 DOI: https://doi.org/10.29313/bcsp.v2i2.4704

Yuliati, E. N. D., & Dyah, A. W. Analisis Kadar Hidrokuinon dalam Krim Pemutih yang Tidak Memiliki Izin BPOM yang Beredar di Kecamatan Ajibarang. Jurnal Mahasiswa Ilmu Kesehatan, 2023;1(2):56-76. doi: https://doi.org/10.59841/jumkes.v1i2.36 DOI: https://doi.org/10.59841/jumkes.v1i2.36

Stevenson, P. G., Fabrice, G., Georges, G., Kirsty, J. M., Gary, R. D., & Andrew, R. S. π-Selective stationary phases: (II) Adsorption behaviour of substituted aromatic compounds on n-alkyl-phenyl stationary phases. Journal of Chromatography A. 2010;1217(33):5365-5376. doi: http://dx.doi.org/10.1016/j.chroma.2010.04.064 DOI: https://doi.org/10.1016/j.chroma.2010.04.064

Nofita, dkk. Penetapan Kondisi Optimum Pengujian Kadar Paracetamol dan Kafein Dengan Kromatografi Cair Kinerja Tinggi. Jurnal Farmasi Malahayati . 2018;1(2):96-106. doi: https://doi.org/10.33024/jfm.v1i2.1242

Cordova, D. M., Darmawan, S. A. N., Alfiyah, M., Utami, M. R., & Nurfadhila, L. Review Artikel: Metode Analisis Obat Tuberkulosis dalam Plasma Darah. Journal of Pharmaceutical and Sciences. 2023;6(2):848-862. doi: http://dx.doi.org/10.36490/journal-jps.com.v6i2.160 DOI: https://doi.org/10.36490/journal-jps.com.v6i2.160

Harmono, H. D. Validasi Metode Analisis Logam Merkuri (Hg) Terlarut pada Air Permukaan dengan Automatic Mercury Analyzer. Indonesian Journal of Laboratory. 2020;2(3):11-16. DOI: https://doi.org/10.22146/ijl.v2i3.57047

Siswanto, A., dkk. Validasi Metode HPLC untuk Penetapan Aspirin dan Asam Salisilat dalam Plasma Kelinci (Lepus curpaeums) secara Simultan. Jurnal Kefarmasian Indonesia. 2016;6(2):68-78. DOI: https://doi.org/10.22435/jki.v6i2.6221.68-78

Maulina, D.I., dkk. Analisis Ibuprofen Menggunakan HPLC dan Pengujian Validasi Metode. Jurnal Ilmiah Wahana Pendidikan. 2024;10(14):390-423. doi: https://doi.org/10.5281/zenodo.13580099

Setiawan, J., & Sari, P. M. N. A. Metode Analisis Rifampisin dalam Plasma Darah. Journal Transformation of Mandalika. 2022;3(4):49-61.

Depkes RI. Farmakope Indonesia edisi VI. Jakarta: Kementrian Kesehatan Republik Indonesia; 2020.

Sari, Dkk. Analisis Kualitatif Merkuri Pada Lotion Pemutih Yang Dijual Di Online Shop Daerah Kota Banjarmasin. Jurnal Ilmiah Ibnu Sina. 2017;2(1):13-19. doi: https://doi.org/10.36387/jiis.v2i1.77

Annisa, S. dkk. Perbandingan Metode Analisis Instrumen HPLC dan UHPLC: Article Review, Farmaka. 2020;17(3):189-197. doi: https://doi.org/10.24198/jf.v17i3.21894

Harvey, David. Modern Analytical Chemistry. New York: McGraw-Hill Comp; 2000

Vidushi, Y.,& Meenakshi, B. A Review on HPLC Method Development and Validation. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Chemistry. 2017;2(6):166-178. doi: 10.26479/2017.0206.12 DOI: https://doi.org/10.26479/2017.0206.12

Most read articles by the same author(s)