Formula Optimization and Taste Masking Efforts for Orally Dissolving Film (ODF) Preparations of Green Betel Leaf Extract (Piper Betle L.) as a Mouth Freshener
Article Sidebar
Main Article Content
Page: 2548-2559
Abstract
Halitosis is caused mainly by bacterial decay and the generation of volatile sulfur compounds. Halitosis has oral causes, such as poor oral hygiene, periodontal disease, tongue coat, food impaction, dentures, damaged restorations, oral carcinoma, and throat infections. Green betel leaves are beneficial for oral health. Betel leaves contain flavonoid compounds, polyphenols, tannins and essential oils. Betel leaves contain essential oils of 1 – 4.2%, phenol compounds and kavikol. Kavikol has activity as a bactericide five times stronger than phenol. This extract can potentially be used as an active ingredient component in orally dissolving film (ODF) preparations. The purpose of this study was to determine the optimal concentration value of HPMC as a polymer and propylene glycol as a plasticizer based on physical properties such as pH, weight uniformity, film thickness, dissolving time and taste masking test of orally dissolving film (ODF) preparations of green betel leaf extract (Piper betle l.). The method used was Simplex Lattice Design (SLD) with a composition of 2% HPMC and 5% propylene glycol. The response results from the pH and dissolution time experiments with an average standard deviation, respectively, ranged from 6.67±0.020-6.73±0.026; 122.21±0.33 -122.85±0.29 mg; 0.2±0.005 mm - 0.21±0.01 mm, and 20.5±0.06 - 30.1±0.05 seconds. In taste masking, it has a fairly good ability to cover the bitter taste of green betel leaf extract.
Downloads
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
References
M. Andani and S. A. Sumiwi, “Review Artikel: Beberapa Tanaman Berkhasiat Untuk Mengatasi Halitosis (Bau Mulut),” Farmaka, vol. 20, no. 3, pp. 56–62, 2022.
N. Amri, A. W. Warogan, and N. Supriyatna, “Efektifitas Oral Hygiene Dengan Kayu Siwak (Salvadora Persica) Untuk Mencegah Halitosis Pada Pasien Stroke Di Rsud Mayjen H.a. Thalib Kerinci - Jambi,” J. Kesehat. Saintika Meditory, vol. 4, no. 1, p. 119, 2021, doi: 10.30633/jsm.v4i1.1296. DOI: https://doi.org/10.30633/jsm.v4i1.1296
R. Fitri, G. Anastasia Br Ginting, M. Furqan, and Z. Rani, “Formulasi Dan Evaluasi Sediaan Orally Dissolving Film (ODF) Yang Mengandung Ekstrak Etanol Jahe Merah (Zingiber Officinale Var Rubrum) sebagai penyembuh sariawan,” vol. 4, no. 2, pp. 158–173, 2025.
A. D. Yoti, S. Nurhalimah, and S. Aminah, “Kajian Literatur : Oral Dissolving Film ( ODF ) dengan Penambahan Ekstrak Jahe Merah ( Zingiber Officinale var . Rubrum ) Sebagai Penyegar Mulut,” vol. 3, pp. 8505–8511, 2024. DOI: https://doi.org/10.30997/karimahtauhid.v3i8.14910
M. A. Triyani, D. Pengestuti, S. L. Khotijah, F. D. Susilaningrum, and T. Ujilestari, “Aktivitas Antibakteri Hand Sanitizer Berbahan Ekstrak Daun Sirih dan Ekstrak Jeruk Nipis,” NECTAR J. Pendidik. Biol., vol. 2, no. 1, pp. 16–23, 2021.
A. Yus Nasution, I. Wardaniati, S. A. Lestari, F. Farmasi, and I. Kesehatan, “Antibacterial Activity of Edible Film with the Addition of Betel Leaf Extract (Piper betle) againts Streptococcus mutans Aktivitas Antibakteri Edible Film dengan Penambahan Ekstrak Daun Sirih (Piper betle) terhadap Streptococcus mutans,” J. Prot. Kesehat., vol. 11, no. 1, pp. 12–16, 2022. DOI: https://doi.org/10.36929/jpk.v11i1.465
S. Inayatullah, “Efek Ekstrak Daun Sirih Hijau (Piper Betle L.) Terhadap Pertumbuhan Bakteri Staphylococcus aureus,” J. Farm. Udayana, p. 23, 2017.
F. Darusman, M. S. Ramadhan, and U. A. Lantika, “Formulasi Dan Karakterisasi Sediaan Orally Dissolving Film Tamsulosin Hidroklorida,” J. Ilm. Farm. Farmasyifa, vol. 6, no. 1, pp. 29–40, 2023, doi: 10.29313/jiff.v6i1.10717. DOI: https://doi.org/10.29313/jiff.v6i1.10717
M. Azizah, “Formulasi dan evaluasi orally disintegrating film dari metoklopramid hidroklorida secara in vitro,” 2018.
Y. P. Tanjung, A. I. Julianti, and A. W. Rizkiyani, “Formulasi dan Evaluasi Fisik Sediaan Edible film dari Ekstrak Etanol Daun Sirih (Piper betle L.) Untuk Obat Sariawan,” Indones. J. Pharm. Sci. Technol., vol. 8, no. 1, p. 42, 2021.
& Dewi, W. A. and D. Mulya, “Formulasi Dan Evaluasi Sifat Fisik Serta Uji Stabilitas Sediaan Edible Film Ekstrak Etanol 96% Seledri (Apium graveolens L) Sebagai Penyegar Mulut,” Іndоnеѕіа Nаturаl Rеѕеаrсh Рhаrmасеutісаl Jоurnаl, vol. 4, no. 2, pp. 32–40, 2019.
W. Murni, H. Pawignyo, D. Widyawati, and N. Sari, “Pembuatan Edible Film dari Tepung Jagung (Zea Mays L.) dan Kitosan,” Pros. Semin. Nas. Tek. Kim. Kejuangan Pengemb. Teknol. Kim. untuk Pengolah. Sumber Daya Alam Indones., pp. 1–9, 2015.
S. P. Palekar, S. Belatikar, and C. Sahane, “In vitro and in vivo evaluation of taste masked chlorhexidine-releasing oral films,” Int. J. Drug Deliv. Technol., vol. 7, no. 3, pp. 234–238, 2017, doi: 10.25258/ijddt.v7i03.9566. DOI: https://doi.org/10.25258/ijddt.v7i03.9566
N. V. Wendersteyt, D. S. Wewengkang, and S. S. Abdullah, “Uji Aktivitas Antimikroba Dari Ekstrak Dan Fraksi Ascidian Herdmania momus dari Perairan Pulau Bangka Likupang Terhadap Pertumbuhan Mikroba Staphylococcus aureus, Salmonella typhimurium dan Candida albicans,” Pharmacon, vol. 10, no. 1, p. 706, 2021, doi: 10.35799/pha.10.2021.32758. DOI: https://doi.org/10.35799/pha.10.2021.32758
K. C. Rani et al., “Development, evaluation, and molecular docking of oral dissolving film of atenolol,” Pharmaceutics, vol. 13, no. 10, pp. 1–17, 2021, doi: 10.3390/pharmaceutics13101727. DOI: https://doi.org/10.3390/pharmaceutics13101727
W. Ode, S. Zubaydah, and M. Handoyo Sahumena, “Fast Dissolving Oral Film Salbutamol Sulfat dengan Menggunakan Polimer HPMC,” J.Chemom.Pharm.Anal, vol. 2021, no. 3, pp. 133–142, 2021.
Ramadhani Reshita Amalia, Riyadi Dody Herdian Saputra, Triwibowo Bayu, and Kusumaningtyas Ratna Dewi, “Review Pemanfaatan Design Expert untuk Optimasi Komposisi Campuran Minyak Nabati sebagai Bahan Baku Sintesis Biodiesel,” J. Tek. Kim. dan Lingkung., vol. 1, no. 1, pp. 11–16, 2017. DOI: https://doi.org/10.33795/jtkl.v1i1.5