Formulation Optimization of Tomato Seed Oil (Solanum lycopersicum) Cleansing Balm by Simplex Lattice Design: Physical Characteristics and Anti-Aging Effects
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Page: 391-401
Abstract
This study aims to optimize the formulation of tomato (Solanum lycopersicum) seed oil-based cleansing balm with a Simplex Lattice Design (SLD) approach and evaluate its physical characteristics for facial cleansing and potential anti-aging effects. The research method used was formulation with the main component variables of shea butter, beeswax, caprylic/capric triglycerides, and tween 20, which were analyzed using SLD to obtain the optimal combination. The optimization results showed that the formulation with concentrations of shea butter (4.97996 %), beeswax (1.88189 %), caprylic/capric triglycerides (42.1382 %), and tween 20 (1 %) provided a good quality preparation with a semi-solid texture, typical beeswax aroma, and bone white color. The physical characteristics of the product, such as melting temperature stabilized at 38.67 °C ± 0.58, spreadability of 5.43 cm ± 0.12, and pH of 5.03 ± 0.06, showed that the product was safe and ideal for the skin. The product stability test for seven days of storage showed no significant changes in melting temperature and spreadability, although there was a slight increase in pH. In addition, the product showed good antioxidant activity with 46.51% free radical inhibition and an IC50 value of 21.46 ppm, indicating potential protection against oxidative stress-induced skin damage. In conclusion, the tomato seed oil cleansing balm optimized through SLD has stable, safe, and effective performance as a skincare product with anti-aging benefits.
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References
Rachmadani AD, Nurlaila SR, Harismah K. Formulasi dan Uji Stabilitas Sediaan Pembersih Wajah (Cleansing oil) Berbahan Dasar Minyak Jarak (Ricinus Communis). jfks. 2022;2(1):104. doi:10.26753/jfks.v2i1.784 DOI: https://doi.org/10.26753/jfks.v2i1.784
Liang W. Toxicity and Effect of Chemicals in Skin Care Products on Human Health. IOP Conf Ser Earth Environ Sci. 2020;512(1):012081. doi:10.1088/1755-1315/512/1/012081 DOI: https://doi.org/10.1088/1755-1315/512/1/012081
Kontaxi NI, Panoutsopoulou E, Ofrydopolou A, Tsoupras A. Anti-Inflammatory Benefits of Grape Pomace and Tomato Bioactives as Ingredients in Sun Oils against UV Radiation for Skin Protection. Appl Sci. 2024;14(14):6236. doi:10.3390/app14146236 DOI: https://doi.org/10.3390/app14146236
Szabo K, Varvara RA, Ciont C, Macri AM, Vodnar DC. An updated overview on the revalorization of bioactive compounds derived from tomato production and processing by-products. J Clean Prod. Published online February 2025:145151. doi:10.1016/j.jclepro.2025.145151 DOI: https://doi.org/10.1016/j.jclepro.2025.145151
Nahdhia N, Rijal MAS, Hendradi E, Widodo RT. Application of the Simplex Lattice Design Method to Determine the Optimal Formula of Diclofenac Sodium Nanoemulsion. JFIKI. 2024;11(2):137-146. doi:10.20473/jfiki.v11i22024.137-146 DOI: https://doi.org/10.20473/jfiki.v11i22024.137-146
Chabib L, Suryani A, Dewi LS, Noviani H, Maharani WHP, Indraswari AA. Pineapple fruit extract (Ananas comosus L. Merr) as an antioxidant and anti-acne agent made with the nano-emulsion gel delivery system. Pharm Educ. 2023;23(2):126-132. doi:10.46542/pe.2023.232.126132 DOI: https://doi.org/10.46542/pe.2023.232.126132
Hartanto H. Emulsifier Concentration Stearic Acid and Triethanolamine on Cream Formulation. Indones Nat Res Pharm J. 2018;3(1):119-130.
Simanullang G, Nurul NFI, Sukrasno. Formulasi dan Evaluasi Stabilitas Fisik Sediaan Lip Balm Minyak Bekatul (Rice Bran Oil). MFI. 2023;18(2). doi:10.53359/mfi.v18i2.230 DOI: https://doi.org/10.53359/mfi.v18i2.230
Chakraborty P, Dey S, Parcha V, Bhattacharya SS, Ghosh A. Design Expert Supported Mathematical Optimization and Predictability Study of Buccoadhesive Pharmaceutical Wafers of Loratadine. Biomed Res Int. 2013;2013:1-12. doi:10.1155/2013/197398 DOI: https://doi.org/10.1155/2013/197398
Pratiwi PD, Arnas DL. Aplikasi Simplex Lattice Design untuk Optimasi Emulgator dalam Krim Minyak Atsiri Kulit Jeruk Manis. Sinteza. 2024;4(2):85-93. doi:10.29408/sinteza.v4i2.26539 DOI: https://doi.org/10.29408/sinteza.v4i2.26539
Nouioura G, Tourabi M, El Ghouizi A, et al. Optimization of a New Antioxidant Formulation Using a Simplex Lattice Mixture Design of Apium graveolens L., Coriandrum sativum L., and Petroselinum crispum M. Grown in Northern Morocco. Plants. 2023;12(5):1175. doi:10.3390/plants12051175 DOI: https://doi.org/10.3390/plants12051175
Mungali M, Sharma N, Gauri. Caprylic/capric triglyceride. In: Naturally Occurring Chemicals Against Alzheimer’s Disease. Elsevier; 2021:139-146. doi:10.1016/B978-0-12-819212-2.00011-6 DOI: https://doi.org/10.1016/B978-0-12-819212-2.00011-6
Jakubczyk E, Kamińska-Dwórznicka A, Kot A. The Impact of Tween 20 on the Physical Properties and Structure of Agar Gel. Gels. 2025;11(3):159. doi:10.3390/gels11030159 DOI: https://doi.org/10.3390/gels11030159
Muadifah A, Tilarso DP, Putri AE, Sowe MS. Antioxidant Effectiveness Test of Kapok Leaf Extract Moisturizer (Ceiba Pentandra (L.) Gaertn.) with DPPH Method. Chempublish. 2024;8(1):1-10. doi:10.22437/chp.v8i1.33234 DOI: https://doi.org/10.22437/chp.v8i1.33234
Nuraeni F, Heliawati L, Nurastuti M. Antioxidant Activity Test from Vegetable Tomato (Solanum lycopersicum) and Cherry Tomato (Solanum lycopersicum var. Cerasiforme) in Hand and Body Cream. He JSAC. 2022;2(1):7-12. doi:10.33751/helium.v2i1.5302 DOI: https://doi.org/10.33751/helium.v2i1.5302