In silico study of compounds in sea cucumber as an imunomodulator
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Josafin Immanuel Siagian, Hari Purnomo, Ediati Sasmito (2022). In silico study of compounds in sea cucumber as an imunomodulator. Journal of Pharmaceutical and Sciences, Vol. 5 No. 1 (2022): JPS Volume 5 Nomor 1 (2022). https://doi.org/10.36490/journal-jps.com.v5i1.99
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Abstract
An immunomodulator is used to normalize body conditions when the immune system is getting weaker. It is believed that sea cucumbers can increase endurance, improve the immune system, increase disease resistance, reduce chronic fatigue syndrome, and reduce stress. This is an experimental study, conducted in in-silico through molecular docking by using the PLANTS application. This study aimed to examine the structures of Holotoxins A and Cucumarioside A2-2 compounds that were broken down into some sea-cucumbers structures, including a non-sugar Stichopus japonicus, a non-sugar Cucumaria japonica, 3 sugar units of Stichopus japonicus, 3 sugar units of Cucumaria japonica, 6 sugar units of Stichopus japonicus, and 5 sugar units of Cucumaria japonica. Further, this study intended to find out the effectiveness of these structures as immunomodulators and their bioinformatics study. Routine and levamisole were used as a comparison. The code of receptor protein used was 5UO1 on the PDB. In the comparison of positive control of Rutin, several tested compounds have a same effect when compared to Rutin. These compounds included 3 sugar units of Stichopus japonicus with a calculated value of 2,37, and 3 sugar units of Cucucmaria japonica with a calculated value of 0,37. The resulting value of the three compounds was T-count < T-table. Hence, there was a meaningful not difference between the three compounds and Rutin as an immunomodulatory medicine
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References
Abbas, A. K., Lichtman, A. H., & Pillai, S. (2020). Basic immunology: Functions and disorders of the immune system (sixth edition). Elsevier.
Aminin, D. (2016). Immunomodulatory Properties of Sea Cucumber Triterpene Glycosides. In P. Gopalakrishnakone, V. Haddad, A. Tubaro, E. Kim, & W. R. Kem (Eds.), Marine and Freshwater Toxins (pp. 381–401). Springer Netherlands. https://doi.org/10.1007/978-94-007-6419-4_3
Aminin, D., Menchinskaya, E., Pisliagin, E., Silchenko, A., Avilov, S., & Kalinin, V. (2015). Anticancer Activity of Sea Cucumber Triterpene Glycosides. Marine Drugs, 13(3), 1202–1223. https://doi.org/10.3390/md13031202
Arba, M. (2019). Buku Ajar Farmasi Komputasi. Deepublish.
Chiang, L.-C., Ng, L. T., Chiang, W., Chang, M.-Y., & Lin, C.-C. (2003). Immunomodulatory activities of flavonoids, monoterpenoids, triterpenoids, iridoid glycosides and phenolic compounds of Plantago species. Planta Medica, 69(7), 600–604. https://doi.org/10.1055/s-2003-41113
Cinelli, M. A., Li, H., Chreifi, G., Poulos, T. L., & Silverman, R. B. (2017). Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors. Journal of Medicinal Chemistry, 60(9), 3958–3978. https://doi.org/10.1021/acs.jmedchem.7b00259
Dong, P., Xue, C., Yu, L., Xu, J., & Chen, S. (2008). Determination of Triterpene Glycosides in Sea Cucumber (Stichopus japonicus) and Its Related Products by High-Performance Liquid Chromatography. Journal of Agricultural and Food Chemistry, 56(13), 4937–4942. https://doi.org/10.1021/jf800893r
Faridah, F., Mumpuni, E., & Yunanto, Y. I. (2019). In-silico Analysis of Chemical Compounds in Green Tea Working on Activators PPAR-γ as Antiobesity. JURNAL ILMU KEFARMASIAN INDONESIA, 17(2), 251. https://doi.org/10.35814/jifi.v17i2.763
Ganeshpurkar, A., & Saluja, A. (2018a). In silico interaction of rutin with some immunomodulatory targets: A docking analysis. INDIAN J. BIOCHEM. BIOPHYS., 55, 7.
Ganeshpurkar, A., & Saluja, A. (2018b). In silico interaction of rutin with some immunomodulatory targets: A docking analysis. INDIAN J. BIOCHEM. BIOPHYS., 55, 7.
Oh, G.-W., Ko, S.-C., Lee, D. H., Heo, S.-J., & Jung, W.-K. (2017). Biological activities and biomedical potential of sea cucumber (Stichopus japonicus): A review. Fisheries and Aquatic Sciences, 20(1), 28. https://doi.org/10.1186/s41240-017-0071-y
Purnomo, H. (2011). Kimia komputasi: Molecular Docking Plants Penambatan molekul PLANTS ( Protein Ligand Ant System) (Ilmu Semut). Pustaka Pelajar.
Purnomo, H. (2019). Molecular Docking Parasetamol dan Analognya menggunakan PLANTS. Rapha Publising.
Sasmito, E. (2017). Imunomudulator Bahan Alami. Rapha Publising.
Shen, W.-C., & Louie, S. G. (2014). Immunology for Pharmacy Students. CRC Press.