Formulation and Evaluation of a Shooting Gel Containing Papaya Leaf Extract (Carica papaya L.) and Aloe Vera Flesh (Aloe vera L.)
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Dewi Ulansari, Sukma Oktafiani Putri, Fefri Perrianty, Acy Istianty (2026). Formulation and Evaluation of a Shooting Gel Containing Papaya Leaf Extract (Carica papaya L.) and Aloe Vera Flesh (Aloe vera L.). Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1834
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Abstract
Daun pepaya (Carica papaya L.) dan daging daun lidah buaya (Aloe vera L.) mengandung konstituen bioaktif yang berpotensi dikembangkan dalam sediaan topikal. Penelitian ini memformulasikan kedua bahan tersebut menjadi tiga formula shooting gel (F0, FI, dan FII) serta mengevaluasi karakteristik fisikokimia, stabilitas fisik jangka pendek, dan tolerabilitas kulit awal. Ekstrak daun pepaya dan daging daun lidah buaya segar dimasukkan ke dalam basis Carbopol 940 dengan jumlah bertingkat 3, 4, dan 5 g per 100 mL. Seluruh formula homogen serta tidak menunjukkan pemisahan fase atau perubahan organoleptik bermakna selama tiga siklus perubahan suhu. Nilai pH F0, FI, dan FII berturut-turut 5,00 ± 0,50; 5,50 ± 0,50; dan 5,50 ± 0,50. Daya sebar meningkat dari 5,05 ± 0,05 menjadi 6,05 ± 0,05 cm, sedangkan viskositas masing-masing sebesar 3115,00 ± 2,00; 3116,00 ± 2,00; dan 2521,33 ± 11,24 cPs. Uji one-way ANOVA menunjukkan tidak terdapat perbedaan bermakna pada pH (p = 0,422), tetapi terdapat perbedaan bermakna pada daya sebar dan viskositas (keduanya p < 0,001). Tidak ditemukan eritema maupun edema pada lima sukarelawan dalam kondisi pengamatan penelitian. FI (viskositas 3116,00 ± 2,00 cPs; daya sebar 5,55 ± 0,05 cm) dipilih sebagai formula kandidat karena mempertahankan viskositas yang sebanding dengan F0, sekaligus memberikan daya sebar dan kandungan bahan aktif yang lebih tinggi
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