Comparison of Liquid Hand Soap Formulations Containing Betel Leaf (Piper betle Linn.) Extract Using Two Different Fatty Acid Bases as an Antiseptic Product
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Rahmat Siregar, Ririn Anjelin, Sukma Oktafiani Putri, Fefri Perrianty (2026). Comparison of Liquid Hand Soap Formulations Containing Betel Leaf (Piper betle Linn.) Extract Using Two Different Fatty Acid Bases as an Antiseptic Product. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1982
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Abstract
Sabun cair nabati memerlukan mutu fisik dan tolerabilitas kulit. Penelitian ini membandingkan dua formula sabun ekstrak etanol daun sirih (Piper betle L.) dengan minyak zaitun (F1) atau minyak kelapa (F2) sebagai basis minyak. Maserasi 500 g serbuk simplisia dalam etanol 70% menghasilkan 50 g ekstrak kental (rendemen 10%). Skrining fitokimia menunjukkan alkaloid, flavonoid, tanin, saponin, dan polifenol. Setiap formula 100 mL mengandung 10 mL ekstrak. Evaluasi meliputi bentuk, warna, aroma, pH menggunakan indikator warna, retensi busa selama lima menit, viskositas (tiga pembacaan per formula), homogenitas visual, dan reaksi kulit jangka pendek. Kedua formula cair dan beraroma sitrus; F1 berwarna lebih pekat. Nilai pH tercatat 9 (F1) dan 5 (F2). Retensi busa masing-masing sebesar 93,77% dan 64,63%, sedangkan viskositas sebesar 831,07 ± 6,11 dan 914,83 ± 7,67 cP. F1 tetap homogen setelah 15 menit, sedangkan F2 mengalami pemisahan fase. Tidak teramati edema, papula, atau vesikula pada 10 sukarelawan selama 30 menit. F1 menunjukkan retensi busa dan homogenitas awal lebih baik, sedangkan F2 lebih kental. Aktivitas antiseptik, stabilitas penyimpanan, dan keamanan pemakaian berulang masih memerlukan pengujian
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