Prevalensi Dan Faktor Resiko Interaksi Obat Potensial Pada Pasien Geriatri Dengan Diabetes Melitus Tipe 2 (Penelitian ini dilakukan di RSUD Haji Provinsi Jawa Timur ).
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Asri Wido Mukti, Ira Purbosari, Nadya Ambarwati (2026). Prevalensi Dan Faktor Resiko Interaksi Obat Potensial Pada Pasien Geriatri Dengan Diabetes Melitus Tipe 2. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1771
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Abstract
Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia that occurs due to the pancreas being unable to secrete insulin, insulin resistance, or both. The purpose of this study was to determine the interaction of antidiabetic drugs with other therapies in geriatric patients with type 2 diabetes mellitus. The research method was carried out observationally by collecting medical records retrospectively for the period January - December 2023 at the Haji Hospital, East Java Province. The results of the study showed that the most commonly given therapeutic profile was monotherapy, namely glimepiride (6.0%), combination therapy of two OAD drugs, namely gliquidone with metformin (12.0%), glimepiride with pioglitazone (10.0%), and Pioglitazone with gliclazide (6.0%). The combination therapy of insulin with OAD that is widely used is vildagliptin with ryzodeg (9.0%). In the therapy of giving one type of long-acting insulin, the most frequently used is ryzodeg (85.0%). While in the provision of 2 types of insulin the most are lantus solostar and apidra solostar (6.0%). Interactions with major severity levels are (19.0%) in spironolactone with candesartan, interactions with moderate severity levels are (81.0%) in glimepiride with metformin. While interactions based on pharmacokinetic mechanisms (66.0%) in glimepiride with metformin. Based on pharmacodynamic mechanisms (34.0%) in glimepiride with insulin degludec.
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[1] W.S. Abdulkadir,E.N. Djuwarno,N. Rasdianah,J. Akuba,M. & TahirF, N.D.. Potensi Interaksi Obat Antidiabetes Melitus Tipe-2 Dengan Obat Antihipertensi.
[2] F. Milita,S. Handayani, Setiaji, B, 2021. Kejadian Diabetes Mellitus Tipe Ii Pada Lanjut Usia Di Indonesia (Analisis Riskesdas 2018). Jurnal Kedokteran Dan Kesehatan, 17(1), 9. [https://doi.org/10.24853/Jkk.17.1.9-20](https://doi.org/10.24853/Jkk.17.1.9-20).
[3] S.D. Astuti,N.D. Lubis, Kurniasari, F, 2019. Evaluasi Ketidaktepatan Pemilihan Obat Berdasarkan Kriteria Stopp Pada Pasien Geriatri. Jurnal Farmasi Indonesia, 14(2), 182–190. [https://doi.org/10.31001/Jfi.V14i2.347](https://doi.org/10.31001/Jfi.V14i2.347).
[4] C.T. Yuniar,E.Y. Sukandar, Lisni, I, N.D.. Identifikasi Drug Therapy Problems (Dtps) Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan Di Salah Satu Rs Swasta Di Bandung.
[5] O.A. Agustin, Fitrianingsih, F, 2021. Kajian Interaksi Obat Berdasarkan Kategori Signifikasi Klinis Terhadap Pola Peresepan Pasien Rawat Jalan Di Apotek X Jambi. Electronic Journal Scientific Of Environmental Health And Disease, 1(1). [https://doi.org/10.22437/Esehad.V1i1.10759](https://doi.org/10.22437/Esehad.V1i1.10759).
[6] Mouazer (2022). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[7] Wang et al. (2024). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[8] Taborat (2023). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[9] E. Reinhard,M.T. Kamaluddin, Melizah, A, 2019. Potensi Terjadinya Interaksi Obat Antidiabetik Oral Pada Pasien Diabetes Melitus Tipe 2 Usia Lanjut. Sriwijaya Journal Of Medicine, 2(3), 205–210. [https://doi.org/10.32539/Sjm.V2i3.83](https://doi.org/10.32539/Sjm.V2i3.83).
[10] Dinesh (tahun tidak tercantum). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[11] K. Komariah, Rahayu, S, 2020. Hubungan Usia, Jenis Kelamin Dan Indeks Massa Tubuh Dengan Kadar Gula Darah Puasa Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Pratama Rawat Jalan Proklamasi, Depok, Jawa Barat. Jurnal Kesehatan Kusuma Husada, 41–50. [https://doi.org/10.34035/Jk.V11i1.412](https://doi.org/10.34035/Jk.V11i1.412).
[12] E. Sundhani,I. Nurzijah,A. Prakoso,M. Rifki, Fajrina, N, 2020. Studi Interaksi Obat Antidiabetes Metformin Dan Glibenklamid Dengan Jamu Pada Tikus Diabetes Yang Diinduksi Aloksan. 12.
[13] Perkeni, 2021. Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Di Indonesia.
[14] L. Nurayati, Adriani, M, 2017. Hubungan Aktifitas Fisik Dengan Kadar Gula Darah Puasa Penderita Diabetes Melitus Tipe 2.
[15] D. LestariD, 2014. Gambaran Kadar Glukosa Darah Puasa Pada Mahasiswa Angkatan 2011 Fakultas Kedokteran Universitas Sam Ratulangi Dengan Indeks Massatubuh 18,5-22,9 Kg/M2. Jurnal E-Biomedik, 1(2). [https://doi.org/10.35790/Ebm.1.2.2013.3308](https://doi.org/10.35790/Ebm.1.2.2013.3308).
[16] Yohana et al. (2023). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[17] American Geriatrics Society (2023). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[18] Mulyani, R, 2016. Hubungan Kepatuhan Dengan Keberhasilan Terapi Berbasis Kombinasi Insulin Dan Obat Antidiabetik Oral Pada Pasien Diabetes Melitus Tipe 2 Di Instalasi Rawat Jalan Rumah Sakit Umum Daerah Ulin Banjarmasin.
[19] Y. Anggriani,A. Rianti,A.N. Pratiwi, Puspitasari, W, 2020. Evaluasi Penggunaan Insulin Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan Di Rumah Sakit X Di Jakarta Periode 2016-2017. Jurnal Sains Farmasi & Klinis, 7(1), 52. [https://doi.org/10.25077/Jsfk.7.1.52-59.2020](https://doi.org/10.25077/Jsfk.7.1.52-59.2020).
[20] Adam (2013). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[21] American Geriatrics Society (2019). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[22] Adam (2019). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[23] Reference details for source cited as [30] are missing from the supplied bibliography. Please provide the complete source details.
[24] Drugs.com (tanggal akses tidak tersedia). Complete bibliographic details (article title, journal/publisher, volume, pages/article number, DOI/URL) were not supplied and must be completed by the author.
[25] F. Noviyanto,R. Mintarsih, Chairani, F, 2023. Gambaran Interaksi Obat Pada Pasien Diabetes Mellitus Tipe 2 Di Rumah Sakit X. Journal Syifa Sciences And Clinical Research, 5(2). [https://doi.org/10.37311/Jsscr.V5i2.21578](https://doi.org/10.37311/Jsscr.V5i2.21578).
[26] D.M. Ningrum,P. Ramdaniah,D.A. Setia Permana, Deny Hariyadi, 2023. Studi Potensi Interaksi Obat Pasien Covid-19 Di Rumah Sakit Umum Daerah Kota Mataram: Study On The Potential Drug Interactions In Covid-19 Patient At The Mataram City General Hospital. Indonesian Journal Of Pharmacy And Natural Product, 6(01), 24–29. [https://doi.org/10.35473/Ijpnp.V6i01.2202](https://doi.org/10.35473/Ijpnp.V6i01.2202)