Effectiveness Test of Nanoparticle Lipid Carrier (NLC) Preparations Combining Green Tea Extract and Alpha Lipoic Acid as Antiaging
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Abdurrahman, Fairuz Yaumil Afra, Widji Soeratri, Djoko Agus Purwanto (2025). Effectiveness Test of Nanoparticle Lipid Carrier (NLC) Preparations Combining Green Tea Extract and Alpha Lipoic Acid as Antiaging. Journal of Pharmaceutical and Sciences, JPS Volume 8 Nomor 2 (2025). https://doi.org/10.36490/journal-jps.com.v8i2.900
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Abstract
Background: Alpha-lipoic acid acts as a co-antioxidant that may enhance the effectiveness of green tea extract as an antiaging agent in a Nanostructured Lipid Carrier (NLC) system by improving its entrapment efficiency. This combination is expected to enhance antiaging benefits through increased collagen density and fibroblast proliferation in the skin. Objective: This study aimed to evaluate the effectiveness of an NLC formulation combining green tea extract and alpha-lipoic acid as an antiaging agent. Methods: The NLC system was prepared using the high-shear homogenization method with three formulations: F1 (without alpha-lipoic acid), F2 (1% alpha-lipoic acid), and F3 (1.5% alpha-lipoic acid). The efficacy test was conducted in vivo using mice, with observed parameters including collagen density and fibroblast count in the dorsal skin over 14 days. Results: The results demonstrated that F2 and F3 exhibited significantly higher collagen density and fibroblast counts compared to F1, indicating that the addition of alpha-lipoic acid enhances antiaging efficacy. Conclusion: This study confirms that the NLC formulation combining green tea extract and alpha-lipoic acid effectively increases collagen density and fibroblast proliferation, suggesting its potential as a superior antiaging agent compared to formulations without the co-antioxidant.
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