Antibacterial Effectiveness of Glodokan Tiang (Polyalthia longifolia) Leaf Extract Against Cutibacterium acnes and Staphylococcus epidermidis
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Abstract
Introduction: Polyalthia longifolia, commonly known as Glodokan tiang, is a plant typically found along roadsides, serving as shade and an ornamental feature in gardens. In addition to its aesthetic function, the leaves of this plant have been found to contain compounds with effective antibacterial activity. Natural ingredients with antibacterial properties, such as Polyalthia longifolia leaf extract, can be an alternative acne treatment due to their lower side effects than chemical drugs. Research Objective: This study aims to test the antibacterial activity of Polyalthia longifolia leaf extract in inhibiting the growth of Staphylococcus epidermidis and Cutibacterium acnes, which are significant causes of acne. Research Method: Polyalthia longifolia leaves were extracted using a maceration method with 70% ethanol as the solvent. The resulting extract was then tested for antibacterial activity using the disc diffusion method at 30%, 35%, 40%, 45%, and 50%. The bacteria used in the tests were Staphylococcus epidermidis and Cutibacterium acnes. Clindamycin was used as a positive control, and sterile water was used as a negative control. The data obtained from the tests were analyzed using the Kruskal-Wallis and post-hoc Games-Howell tests. Results: The study showed that Polyalthia longifolia leaf extract at various concentrations (30%, 35%, 40%, 45%, 50%) exhibited significant antibacterial activity against both bacteria tested. At a concentration of 50%, the extract demonstrated the most potent inhibitory effect on Cutibacterium acnes and Staphylococcus epidermidis, with inhibition zones reaching 15.82 mm and 15.74 mm, respectively. Conclusion: Polyalthia longifolia leaf extract shows significant antibacterial potential against Staphylococcus epidermidis and Cutibacterium acnes. The 50% extract concentration exhibited the most potent inhibitory effect, making it a promising candidate for natural acne treatment with minimal side effects.
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References
Ariyanti EL, Handayani RP, Yanto ES. Formulasi Sediaan Serum Antioksidan dari Ekstrak Sari Tomat (Solanum Lycopersicum L.) dan Ekstrak Kayu Manis (Cinnamomum Burmannii) sebagai Perawatan Kulit. J Holist Heal Sci (Jurnal Ilmu Holistik Dan Kesehatan) 2020;4:50–7. https://doi.org/10.51873/jhhs.v4i1.80. DOI: https://doi.org/10.51873/jhhs.v4i1.80
Madelina W, Sulistiyaningsih. Review: Resistensi Antibiotik pada Terapi Pengobatan Jerawat. J Farmaka 2018;16:105–17.
Biosci IJ, Parvin A, Akter J, Hassan M, Biswas N. Study on the comparative antibacterial activity of Polyalthia longifolia ( Debdaru ) leaf extracts to some selective pathogenic bacterial strains. Int J Biosci 2013;6655:17–24. DOI: https://doi.org/10.12692/ijb/3.5.17-24
Yulistia B, Anita A, Meita I, Fatimah N, Heri W. Jurnal Farmasi Lampung. J Farm Lampung JFL 2018;7:15–27.
Jothy SL, Choong YS, Saravanan D, Deivanai S, Latha LY, Vijayarathna S, et al. Polyalthia longifolia Sonn: An ancient remedy to explore for novel therapeutic agents. Res J Pharm Biol Chem Sci 2013;4:714 30.
Kaur S, Mondal P. Study of Total Phenolic and Flavonoid Content, Antioxidant Activity and Antimicrobial Properties of Medicinal Plants. J Microbiol Exp 2014;1. https://doi.org/10.15406/jmen.2014.01.00005. DOI: https://doi.org/10.15406/jmen.2014.01.00005
Anindhita, Anung M, Khasanah K, Priharwanti A, Sulistyanto I, Pekalongan U. Formulasi Sediaan Tablet Hisap Ekstrak Daun Glodokan Tiang dengan CMC Na sebagai Bahan Pengikat. Cendekia J Pharm 2022;6:227–43. DOI: https://doi.org/10.31596/cjp.v6i2.198
Wijaya A, Noviana N. Penetapan kadar air simplisia daun kemangi (Ocimum basilicum L.) berdasarkan perbedaan metode pengeringan. J Ris Kefarmasian Indones 2022;4:185–94.
Soemarie YB, Apriliana A, Indriastuti M. Uji aktivitas antibakteri ekstrak etanol daun glodokan tiang (Polyalthia longifolia S.) terhadap bakteri Propionibacterium acnes. JFL J Farm Lampung 2018;7. DOI: https://doi.org/10.37090/jfl.v7i1.33
Retnaningsih A, Primadiamanti A, Marisa I. Uji Daya Hambat Ekstrak Etanol Biji Pepaya Terhadap Bakteri Escherichia coli Dan Shigella Dysentriae Dengan Metode Difusi Sumuran. J Anal Farm 2019;4:122–9.
Egra S, Mardhiana, Rofin M, Adiwena M, Jannah N, Kuspradini H, et al. Aktivitas Antimikroba Ekstrak Bakau (Rhizophora mucronata) dalam Menghambat Pertumbuhan Ralstonia Solanacearum Penyebab Penyakit Layu. Agrovigor J Agroekoteknologi 2019;12:26. https://doi.org/10.21107/agrovigor.v12i1.5143. DOI: https://doi.org/10.21107/agrovigor.v12i1.5143
Fitriani T, Nashihah S. Uji Daya Hambat Ekstrak Etanol Daun Rambai (Sonneratia Caseolaris (L) Engl) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis. J Farm Indones 2021;13:40–53. https://doi.org/10.35617/jfionline.v13i1.65. DOI: https://doi.org/10.35617/jfionline.v13i1.65
Ahmad A, Abdullah S. Evaluation of the Antibacterial Activity of Some Medicinal Plants Extract Against Some Human Pathogenic Bacteria. Pakistan J Biotechnol 2020;17:9 15. https://doi.org/10.34016/pjbt.2020.17.1.2. DOI: https://doi.org/10.34016/pjbt.2020.17.1.2
N.S. A, K.C. A, J.C. Ii, A.N. U, H.C. E, A.T. V-A, et al. Antibacterial Activities of the Aqueous and Ethanolic Extracts of the Male and Female Carica Papaya Leaves on Some Pathogenic Bacteria. Bioeng Biosci 2017;5:25–9. https://doi.org/10.13189/bb.2017.050201. DOI: https://doi.org/10.13189/bb.2017.050201
Lan TTQ, Khiem VM, Tin N Van. Antibacterial and Antioxidant Activity of Rhodomyrtus Tomentosa and Cinnamomum Zeylanicum Crude Extracts. Vet Sci Res 2021;3. https://doi.org/10.30564/vsr.v3i1.2623. DOI: https://doi.org/10.30564/vsr.v3i1.2623
Rizki SA, Latief M, Fitrianingsih F, Rahman H. Uji Aktivitas Antibakteri Ekstrak N-heksan, Etil asetat, dan Etanol Daun Durian (Durio zibethinus Linn.) terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis. Jambi Med J J Kedokt Dan Kesehat 2022;10:442–57.
Martsiningsih A, Suyana S, Noviani A, Rahmawati U, Sujono S, Dwi Astuti F. Pengaruh Waktu Inkubasi Terhadap Diameter Zona Hambat Antibiotik Pada Uji Sensitivitas Bakteri Klebsiella Pneumonia. Meditory J Med Lab 2023;11:1 8. https://doi.org/10.33992/meditory.v11i1.2361. DOI: https://doi.org/10.33992/meditory.v11i1.2361
Sattar A, Abbas AS, Naseem S, Mumtaz M, Shabbir A, Mirza S. Evaluation of Phytochemicals and Antibacterial Usefulness of Citrus Limon &Amp; Cicer Arietinum in Synergistic Effect With Antibiotics Against Clinically Important Bacteria 2024;4:244–9. https://doi.org/10.61919/jhrr.v4i1.174. DOI: https://doi.org/10.61919/jhrr.v4i1.174
Abdallah EM. Preliminary Screening for Antibacterial Properties of the Male Flowers of Phoenix Dactylifera. South Asian J Res Microbiol 2019:1–6. https://doi.org/10.9734/sajrm/2019/v3i230081. DOI: https://doi.org/10.9734/sajrm/2019/v3i230081
Ammor K, Bousta D, Jennan S, Bennani B, Chaqroune A, Mahjoubi F. Phytochemical Screening, Polyphenols Content, Antioxidant Power, and Antibacterial Activity Of Herniaria Hirsuta From Morocco. Sci World J 2018;2018:1–7. https://doi.org/10.1155/2018/7470384. DOI: https://doi.org/10.1155/2018/7470384
Dougnon V, JR K. Antibacterial and Wound Healing Properties of Terminalia Superba Engl. And Diels (Combretaceae) in Albino Wistar Rats. J Bacteriol Parasitol 2015;s2. https://doi.org/10.4172/2155-9597.1000206. DOI: https://doi.org/10.4172/2155-9597.1000206
Sanhueza L, Melo R, Montero R, Maisey K, Mendoza L, Wilkens M. Synergistic Interactions Between Phenolic Compounds Identified in Grape Pomace Extract With Antibiotics of Different Classes Against Staphylococcus Aureus and Escherichia Coli. PLoS One 2017;12:e0172273. https://doi.org/10.1371/journal.pone.0172273. DOI: https://doi.org/10.1371/journal.pone.0172273
poudineh F, Azari AA, Fozouni L. Antibacterial Activity of Ethanolic Extract of Matricaria Chamomilla, Malva Cylvestris, and Capsella Bursa-Pastoris Against Multidrug-Resistant Pseudomonas Aeruginosa Strains. Avicenna J Clin Microbiol Infect 2021;8:23–6. https://doi.org/10.34172/ajcmi.2021.05. DOI: https://doi.org/10.34172/ajcmi.2021.05
Chandra P, Shufyani F, Athaillah A, Ginting OSB, Nasution M. Formulasi Dan Evaluasi Sediaan Emulgel Ekstrak Etanol Dari Serai (Cymbopogon Citratus) Terhadap Bakteri Propionibacterium Acne. Forte J 2023;3:158–66. DOI: https://doi.org/10.51771/fj.v3i2.631
La Bassy L, Tunny R, Sahari SW. Uji Aktivitas Antibakteri Ekstrak Etanol Mentimun (Cucumis sativus L) Asal Desa Waimital terhadap Pertumbuhan Bakteri Cutibacterium acnes dengan Metode Difusi Sumuran. Termom J Ilm Ilmu Kesehat Dan Kedokt 2023;1:164–75. DOI: https://doi.org/10.55606/jurrike.v1i1.1002
Kurniawati, Putri, Dwi, Faizah H, Rokhim S. Skrining Fitokimia Ekstrak Etanol Daun Glodokan Tiang (Polyalthia longifolia). J Biol Sci Biodivers J Homepage 2021;1:216–23.
Tyastirin E, Rachmawati Y. Uji Antibakteri Ekstrak Daun Glodokan Tiang (Polyalthia longifolia) Terhadap Pertumbuhan Bakteri Staphylococcus epidermidis. BIOMETRIC 2022;2:70–5. DOI: https://doi.org/10.52161/jiphar.v9i2.418
Qamariah N, Handayani R, Mahendra AI. Uji Hedonik dan Daya Simpan Sediaan Salep Ekstrak Etanol Umbi Hati Tanah: Hedonik Test and Storage Test Extract Ethanol the Tubers of Hati Tanah. J Surya Med 2022;7:124–31. DOI: https://doi.org/10.33084/jsm.v7i2.3213