Interpolated Melolabial Flap sebagai Pilihan Rekonstruksi Estetis dan Fungsional untuk Defek Nasal Akibat Karsinoma Sel Basal: Laporan Kasus Serial

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Statistik artikel

Data OJS dan sumber sitasi
Tayangan abstrak46OJS
Unduhan artikel16OJS
Sitasi Crossref02026-10-20
Sitasi Google Scholar02026-10-20

Tayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar

Isi Artikel Utama

Utiya Nur Laili
Nugrohoaji Dharmawan
Putri Jati Utami
Larisa Sabrina Rahadiyanti

Abstrak

Karsinoma sel basal (KSB) adalah neoplasma ganas pada kulit yang dipicu oleh paparan sinar ultraviolet (UV) secara terus-menerus. Terdapat beberapa teknik flap yang tersedia saat ini seperti rotation flap, transposition flap dan advancement flap. Kami melaporkan 2 kasus tumor pada area nasal berupa KSB yang menjalani tindakan rekonstruksi menggunakan flap dengan teknik interpolated melolabial flap. Kasus pertama adalah seorang perempuan berusia 48 tahun dengan benjolan di daerah hidung sebelah kiri sejak 1 tahun yang lalu yang semakin membesar. Pasien didiagnosis dengan KSB berdasarkan anamnesis, pemeriksaan dermoskopi dan histopatologis. Kasus kedua adalah seorang perempuan berusia 58 tahun dengan benjolan pada hidung sebelah kanan sejak 1 tahun yang lalu yang semakin membesar. Kedua pasien didiagnosis dengan KSB dan menjalani eksisi tumor dengan bedah eksisi luas disertai kontrol margin, yang dilanjutkan dengan rekonstruksi defek ala nasi menggunakan teknik interpolated melolabial flap. Kedua kasus menunjukkan hasil yang baik setelah operasi dengan efek samping minimal serta tidak didapatkan adanya rekurensi. Terapi KSB bertujuan untuk menghilangkan tumor sepenuhnya dan mencegah rekurensi dengan mempertimbangkan ukuran, lokasi dan hasil pemeriksaan histologis serta kondisi kesehatan pasien. Pemilihan jenis flap sebagai terapi KSB didasarkan pada ukuran defek, lokasi, karakteristik jaringan, serta kondisi umum pasien. Interpolated flap merupakan teknik memindahkan flap ke defek lesi dengan mempertahankan jembatan kulit (pedikel) sebagai basis vaskularisasi. Interpolated melolabial flap dapat memberikan hasil yang optimal setelah operasi dan proses penyembuhan yang cepat pada kasus karsinoma sel basal area nasal.

Rincian Artikel

Bagian

Original Articles

Cara Mengutip

Interpolated Melolabial Flap sebagai Pilihan Rekonstruksi Estetis dan Fungsional untuk Defek Nasal Akibat Karsinoma Sel Basal: Laporan Kasus Serial. (2026). Journal of Pharmaceutical and Sciences, 9(3), 2741-2758. https://doi.org/10.36490/journal-jps.com.v9i3.1616

Referensi

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, et al. European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer. 2023;192:32-54.

McDaniel B, Badri T, Steele RB. Basal Cell Carcinoma. StatPearls Publishing; 2024.

Dika E, Scarfì F, Ferracin M, Broseghini E, Marcelli E, Bortolani B, et al. Basal cell carcinoma: A comprehensive review. Int J Mol Sci. 2020;21:1-11.

Santini CF, Istiadi H, Kusumaningrum N, Miranti IP. Karakteristik Klinikopatologik Karsinoma Sel Basal di RSUP Dr. Kariadi Semarang Periode 1 Januari 2019–31 Desember 2021. Universitas Diponegoro; 2022:22-50.

Kevinsyah AP, Didik SH, Kus E. Profil Histopatologi Karsinoma Sel Basal di Instalasi Patologi Anatomik RSUP Dr. Sardjito Yogyakarta Tahun 2012–2013. Universitas Gadjah Mada.

Bauer A, Haufe E, Heinrich L, Seidler A, Schmitt J. Basal cell carcinoma and solar UV exposition (update on occupational skin cancer-basal cell carcinoma and solar UV exposure). Hautarzt. 2021;72(6):484-492.

Toha SS, Rahman A, Mochtar M, Julianto I, Dharmawan N, Mawardi P, et al. Kejadian karsinoma sel basal di RSUD Dr. Moewardi Surakarta berdasarkan subtipe histopatologi menurut jenis kelamin, usia, lokasi anatomi, dan diameter tumor. CDK. 2019;46(4):1-5.

Marei HE, Althani A, Afifi N, Hasan A, Caceci T, Pozzoli G, et al. p53 signaling in cancer progression and therapy. Cancer Cell Int. 2021;21(703):1-15.

Cameron MC, Lee E, Hibler BP, Giordano CN, Barker CA, Mori S, et al. Basal cell carcinoma: Contemporary approaches to diagnosis, treatment, and prevention. J Am Acad Dermatol. 2019;80:321-339.

Cocuz IG, Popelea MC, Niculescu R, Manea A, Sabău AH, Tinca AC, et al. Pathophysiology, histopathology, and differential diagnostics of basal cell carcinoma and cutaneous squamous cell carcinoma—An update from the pathologist’s point of view. Int J Mol Sci. 2024;25(4).

Richmond-Sinclair NM, Pandeya N, Ware RS, Neale RE, Williams GM, Van Der Pols JC, et al. Incidence of basal cell carcinoma multiplicity and detailed anatomic distribution: Longitudinal study of an Australian population. J Invest Dermatol. 2009;129(2):323-328.

Fania L, Didona D, Morese R, Campana I, Coco V, Di Pietro FR, et al. Basal cell carcinoma: From pathophysiology to novel therapeutic approaches. Biomedicines. 2020;8:1-38.

Naik PP, Desai MB. Basal cell carcinoma: A narrative review on contemporary diagnosis and management. Oncol Ther. 2022;10(2):317-335.

Nasr I, McGrath EJ, Harwood CA, Botting J, Buckley P, Budny PG, et al. British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021. Br J Dermatol. 2021;185:899-920.

Ramsey ML, Ellison CA, Hohman MH, Al Aboud AM. Interpolated flaps. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025.

Huentequeo CM, Siso SC, Unibazo AZ, Pino DD, Alister JPH, Mayer, et al. Local flaps in facial reconstruction: Treatment alternatives. Int J Odontostomat. 2021;15(2):538-550.

Salzano G, Maffìa F, Vaira LA, Committeri U, Copelli C, Maglitto F, et al. Locoregional flaps for the reconstruction of midface skin defects: A collection of key surgical techniques. J Clin Med. 2023;12(11):3700.

Zhang W, Zeng W, Jiang A, He Z, Shen X, Dong X, Feng J, Lu H. Global, regional and national incidence, mortality and disability-adjusted life-years of skin cancers and trend analysis from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019. Cancer Med. 2021;10(14):4905-4922.

Pan Y, Tang B, Guo Y, Cai Y, Li YY. Global burden of non-melanoma skin cancers among older adults: A comprehensive analysis using machine learning approaches. Sci Rep. 2025;15(1):152-166.

Kavoussi H, Ebrahimi A, Rezaei M, Najafi F, Zarpoosh M, Kavoussi R. Comparison of demographic and clinicopathological characteristics of basal cell carcinoma on the nose and other sites of the face: A cross-sectional study. Iran J Otorhinolaryngol. 2021;33(118):257-262.

Yang H, Almadani N, Thompson EF, Tessier-Cloutier B, Chen J, Ho J, et al. Classification of vulvar squamous cell carcinoma and precursor lesions by p16 and p53 immunohistochemistry: Considerations, caveats, and an algorithmic approach. Mod Pathol. 2023;36(6):100-145.

Zhang W, Zeng W, Jiang A, He Z, Shen X, Dong X, et al. Global, regional and national incidence, mortality and disability-adjusted life-years of skin cancers and trend analysis from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019. Cancer Med. 2021;10(14):4905-4922.

Ürün YG, Fiçicioğlu S, Ürün M, Can N. Clinical, dermoscopic and histopathological evaluation of basal cell carcinoma. Dermatol Pract Concept. 2023;13(1):1-11.

Behera B, Kumari R, Thappa DM, Gochhait D, Srinivas BH, Ayyanar P, et al. Dermoscopic features of basal cell carcinoma in skin of color: A retrospective cross-sectional study from Puducherry, South India. J Am Acad Dermatol. 2023;89(2):254-260.

Șerbănescu MS, Bungărdean RM, Georgiu C, Crișan M. Nodular and micronodular basal cell carcinoma subtypes are different tumors based on their morphological architecture and their interaction with the surrounding stroma. Diagnostics (Basel). 2022;12(7):1636.

Saizan A, Taylor S, Elbuluk N. Pigmented basal cell carcinoma: An argument for sub-classification. J Drugs Dermatol. 2023;22(2):217-218.

Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA. Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review. J Am Acad Dermatol. 2021;85(3):653-664.

Adya KA, Inamadar AC, Palit A. Dermoscopic pigment network: Characteristics in non-melanocytic disorders. Indian Dermatol Online J. 2020;11:146-153.

Kim RH, Armstrong AW. Non-melanoma skin cancer. Dermatol Clin. 2012;30:125-139.

Paolino G, Donati M, Didona D, Mercuri SR, Cantisani C. Histology of non-melanoma skin cancers: An update. Biomedicines. 2017;5(4):1-12.

Tímár J, Ladányi A. Molecular pathology of skin melanoma: Epidemiology, differential diagnostics, prognosis and therapy prediction. Int J Mol Sci. 2022;23(10):5384.

Rashid S, Shaughnessy M, Tsao H. Melanoma classification and management in the era of molecular medicine. Dermatol Clin. 2023;41(1):49-63.

Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, et al. Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines. Eur J Cancer. 2019;118:10-34.

Veldhuizen IJ, Budo J, Kallen EJJ, Sijben I, Hölscher MC, van der Hulst RRWJ, et al. A systematic review and overview of flap reconstructive techniques for nasal skin defects. Facial Plast Surg Aesthet Med. 2021;23(6):476-481.

Rao JK, Shende KS. Overview of local flaps of the face for reconstruction of cutaneous malignancies: Single institutional experience of seventy cases. J Cutan Aesthet Surg. 2016;9(4):220-225.

Patel PM, Greenberg JN, Kreicher KL, Burkemper NM, Bordeaux JS, Maher IA. Combination of melolabial interpolation flap and nasal sidewall and cheek advancement flaps allows for repair of complex compound defects. Dermatol Surg. 2018;44(6):785-795.

Gado SK, Karimnejad K, Maher IA, Gruber PJ, Walen S. Interpolated flaps. Facial Plast Surg. 2017;33(1):34-42.

Wald J, Tinklepaugh A, Husain Z, Ciocon D. Alar reconstruction after failure of an interpolated melolabial flap. Dermatol Surg. 2018;44(12):1623-1626.

Boyette JR. Reconstruction of a nasal alar defect, melolabial interpolation flap. In: Stack BC Jr, Moreno MA, Boyette JR, Vural EA, eds. Matrix Head and Neck Reconstruction. Springer; 2021:5-52.

Lukowiak TM, Perz AM, Veerabagu SA, Lee MP, Neal D, Aizman L, et al. Patient quality of life after interpolated flap repair of nasal Mohs surgery defects: A multicenter prospective cohort study. JAMA Dermatol. 2021;157(10):1213-1216.

Perz AM, Lukowiak TM, Lee MP, Neal D, Aizman L, Miller CJ, et al. Postoperative complications after interpolated flap repair for Mohs defects of the nose: A multicenter prospective cohort study. Dermatol Surg. 2023;49(2):135-139.

Chakraborty SS, Goel AD, Sahu RK, Midya M, Acharya S, Shakrawal N, et al. Effectiveness of nasolabial flap versus paramedian forehead flap for nasal reconstruction: A systematic review and meta-analysis. Aesthetic Plast Surg. 2023;47(1):313-329.

Ji J, Alexander N, Enin K, Spataro E. Factors associated with outcomes of facial reconstruction after Mohs micrographic surgery. Craniomaxillofac Trauma Reconstr. 2024;17(4):131-137.

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