Hubungan Kadar Enzim Alkaline Phosphatase Dengan Kejadian Enamel Defect Gigi Permanen pada Anak
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Reno Wiska Wulandari, Nila Kasuma, Hardisman Dasman, Hirowati Ali (2026). Hubungan Kadar Enzim Alkaline Phosphatase Dengan Kejadian Enamel Defect Gigi Permanen pada Anak. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 1 (2026). https://doi.org/10.36490/journal-jps.com.v9i1.1304
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Abstract
Enamel gigi merupakan jaringan yang paling keras yang ada di dalam tubuh manusia yang dibentuk oleh interaksi antara protein matriks dan enzim, terkhusus kadar enzim alkaline phosphatase (ALP). Gangguan dalam regulasi atau aktivitas ALP dapat menyebabkan mineralisasi enamel yang tidak tepat dan meningkatkan risiko terjadinya Developmental Defects of Enamel (DDE) pada gigi permanen. Tujuan penelitian adalah menganalisis hubungan kadar enzim ALP dengan kejadian DDE pada anak. A comparative cross-sectional study was conducted on 60 children divided into two groups: normal enamel and DDE. Pemeriksaan enamel gigi menggunakan modified DDE index. Saliva dianalsis dengan metode Kolorimetrik secara duplo. Analisa statistic menggunakan Mann-Whitney test dengan hasil signifikan ketika p < 0,05. Hasil penelitian menunjukan kadar ALP rata-rata pada kelompok enamel normal lebih rendah [5,90 (1,38 – 27,82) mg/mL] dibandingkan dengan kelompok DDE [7,76 (0,13-11,89) mg/mL] dengan perbedaan yang tidak signifikan (p > 0,05). Berdasarkan temuan ini, kadar ALP dalam saliva tidak memiliki hubungan langsung yang kuat dengan DDE, sehingga potensinya sebagai biomarker tunggal untuk deteksi dini DDE terbatas.
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Arrow P, Piggott S, Jamieson L, Brennan D, Tonmukayakul U, Kularatna S, et al. Dental enamel defects and dental caries of primary teeth among Indigenous children in Western Australia. Aust Dent J. 2023;68(1):35–41.
Vélez-León E, Albaladejo-Martínez A, Pacheco-Quito EM, Armas-Vega A, Delgado-Gaete A, Pesántez-Ochoa D, et al. Developmental enamel defects in children from the Southern region of Ecuador. Children. 2022;9(11):1755.
Djamaluddin N, Anwar AI, Pasiga B, Akbar FH, Samad R, Pratiwi R, et al. Description of dental caries status and enamel defect on children aged 6-10 years in District of North Mamuju. Makassar Dent J. 2020;9(1).
Hutagaol R, Sukarna RA, Susanti N, Sijabat M, Adriani RB, Aini SN, et al. Buku Ajar Anatomi Fisiologi. Jakarta: CV. Zahir Publishing; 2022.
Klimuszko E, Orywal K, Sierpinska T, Sidun J, Golebiewska M. The evaluation of zinc and copper content in tooth enamel without any pathological changes–an in vitro study. Int J Nanomedicine. 2018;1257–64.
Kemenkes RI. Riset Hasil Kesehatan Dasar 2018. 2018.
Prihastari L, Prasonto D, Rintoko B, Erry HWJ. Stunting dan Malnutrisi Penyebab Kelainan Email Gigi Anak dan Early Childhood Caries (ECC): Komprehensif Review. Andalas Dent J. 2023;11(2):92–102.
Zhu Y, Wang Y, Zhang S, Li J, Li X, Ying Y, et al. Association of polymicrobial interactions with dental caries development and prevention. Front Microbiol. 2023;14:1162380.
Amalia R. KARIES GIGI: Perspektif Terkini Aspek Biologis, Klinis, dan Komunitas. UGM PRESS; 2021.
Innes NPT, Robertson MD. Recent advances in the management of childhood dental caries. Arch Dis Child. 2018;103(4):311–5.
Brescia AV, Montesani L, Fusaroli D, Docimo R, Di Gennaro G. Management of enamel defects with resin infiltration techniques: two years follow up retrospective study. Children. 2022;9(9):1365.
Carey CM. Remineralization of early enamel lesions with apatite-forming salt. Dent J. 2023;11(8):182.
Collignon AM, Vergnes JN, Germa A, Azogui S, Breinig S, Hollande C, et al. Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review. Front Pediatr. 2022;10(February):1–13.
Sheoran N, Garg S, Dhindsa A, Saraf BG, Juneja V, Mavi S. Study of Developmental Defects of Enamel in Young Permanent Maxillary Incisors in 11–13-year-old Indian Children for Occurrence Distribution and Associated Factors. Int J Clin Pediatr Dent. 2023;16(Suppl 2):176.
Looh SC, Soo ZMP, Wong JJ, Yam HC, Chow SK, Hwang JS. Aggregatibacter actinomycetemcomitans as the aetiological cause of rheumatoid arthritis: what are the unsolved puzzles? Toxins (Basel). 2022;14(1):50.
Pan W, Wang Q, Chen Q. The Cytokine Network Involved in The Host Immune Response to Periodontitis. Int J Oral Sci. 2019;11(3):30.
Li YT, Tian QL, He PC, Zheng LW. [Enamel developmental defects: environmental factors and clinical management]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese J Stomatol. 2023 Oct;58(11):1198–204.
Hong CL, Broadbent JM, Thomson WM. Long-term survival of enamel-defect-affected teeth. Caries Res. 2020;54(4):350–7.
Wulandari RW, Kasuma N. The Relationship Between Calcium Intake and Levels of Alkaline Phosphatase Enzyme with Delayed Eruption of Permanent Canines in Stunting Children. J Int Dent Med Res. 2023;16(3).
Alhazmi N, Trotman CA, Finkelman M, Hawley D, Zoukhri D, Papathanasiou E. Salivary alkaline phosphatase activity and chronological age as indicators for skeletal maturity. Angle Orthod. 2019;89(4):637–42.
Nugroho MR, Sasongko RN, Kristiawan M. Faktor-faktor yang mempengaruhi kejadian stunting pada anak usia dini di Indonesia. J Obs J Pendidik Anak Usia Dini. 2021;5(2):2269–76.
Nurbaeva MK, Eckstein M, Devotta A, Saint-Jeannet JP, Yule DI, Hubbard MJ, et al. Evidence that calcium entry into calcium-transporting dental enamel cells is regulated by cholecystokinin, acetylcholine and ATP. Front Physiol. 2018;9:801.
Tournis S, Yavropoulou MP, Polyzos SA, Doulgeraki A. Hypophosphatasia. J Clin Med. 2021;10(23):5676.
Tosto C, Tirillò J, Sarasini F, Cicala G. Hybrid metal/polymer filaments for fused filament fabrication (FFF) to print metal parts. Appl Sci. 2021;11(4):1444.
Stevens PE, Ahmed SB, Carrero JJ, Foster B, Francis A, Hall RK, et al. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. 2024;105(4):S117–314.
Hegde SS, Revankar AV, Patil AK. Identification of bone-specific alkaline phosphatase in saliva and its correlation with skeletal age. Indian J Dent Res. 2018;29(6):721–5.
Koppolu P, Sirisha S, Mishra A, Deshpande K, Lingam AS, Alotaibi DH, et al. Alkaline phosphatase and acid phosphatase levels in saliva and serum of patients with healthy periodontium, gingivitis, and periodontitis before and after scaling with root planing: A clinico-biochemical study. Saudi J Biol Sci. 2021;28(1):380–5.
Hardisman, Dr, MHID P. Tanya Jawab metodologi Penelitian Kesehatan. Yogyakarta: Gosyen Publishing; 2021.
Taufiq A, Bachtiar BM, Bachtiar EW, Herda E. The role of NMT induction on odontogenic proliferation and differentiation of dental pulp stem cells. Heliyon. 2021;7(4).
Cannalire G, Pilloni S, Esposito S, Biasucci G, Di Franco A, Street ME. Alkaline phosphatase in clinical practice in childhood: Focus on rickets. Front Endocrinol (Lausanne). 2023;14:1111445.
Vimalraj S. Alkaline phosphatase: Structure, expression and its function in bone mineralization. Gene. 2020 Sep;754:144855.
Abdelrahman SA, Abbas HMED, Hanafy SS. Salivary Alkaline Phosphatase as a Dual Biomarker for Dental Caries and Obesity in Egyptian Children: A Cross-sectional Study. Int J Oral Dent Heal. 2024;10(2).
Piekoszewska-Ziętek P, Spodzieja K, Olczak-Kowalczyk D. Influence of Vitamin D on Developmental Defects of Enamel (DDE) in Children and Adolescents: A Systematic Review. Vol. 17, Nutrients. 2025. p. 1317.
Rajab HA. The Effect of Vitamin D Level on Parathyroid Hormone and Alkaline Phosphatase. Diagnostics (Basel, Switzerland). 2022 Nov;12(11).
Salehabadi N, Moallem SA, Nahvi A. Salivary proteins, enzymes and immune factors associated with early childhood caries: A Narrative Review. 2022.