Formulasi dan Evaluasi Fisik Sediaan Granul Stevia Sebagai Pemanis Alami Dengan Penambahan Polivinilpirolidon (PVP) Sebagai Pengikat
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Nur Achsan Al-Hakim, Hestiary Ratih, Niken Sabrilla (2025). Formulasi dan Evaluasi Fisik Sediaan Granul Stevia Sebagai Pemanis Alami Dengan Penambahan Polivinilpirolidon (PVP) Sebagai Pengikat. Journal of Pharmaceutical and Sciences, JPS Volume 8 Nomor 2 (2025). https://doi.org/10.36490/journal-jps.com.v8i2.661
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Pengembangan penemuan pemanis alami terus dilakukan untuk mewujudkan perilaku hidup sehat pada penggunaannya di dalam suatu produk makanan dan minuman, termasuk dalam formulasi sediaan farmasi. Stevia (Stevia rebaudiana) adalah tanaman yang mengandung zat rasa manis yang tinggi dan memiliki nilai kalori yang paling rendah. Penelitian ini bertujuan untuk memformulasikan dan melakukan evaluasi fisik sediaan granul ekstrak stevia menggunakan metode granulasi basah dengan penambahan variasi konsentrasi Polivinilpirolidon (PVP) sebagai bahan pengikat, F0 (tanpa PVP), F1 (1%), F2 (3%), dan F3 (5%). Evaluasi fisik sediaan granul stevia meliputi, uji organoleptik, kandungan lembab, laju alir, sudut istirahat, indeks kompresibilitas dan waktu larut granul dalam air. Hasil evaluasi fisik sediaan granul selama penyimpanan 28 hari menunjukkan bahwa F3 merupakan formula terbaik dibandingkan formula lainnya, dibuktikan dengan hasil analisis statistik menggunakan one way ANOVA menunjukkan perbedaan signifikan (p<0,05) antar formulasi. Hasil evaluasi diperoleh adalah kandungan lembab (<3%), laju alir (10,23 g/detik), sudut istirahat (27°), indeks kompresibilitas (10%) dan waktu larut granul (<1 menit). Penelitian ini menunjukkan bahwa penggunaan konsentrasi PVP 5% pada F3 sebagai bahan pengikat dapat meningkatkan sifat fisik sediaan granul stevia menjadi lebih baik dibandingkan konsentrasi 1% dan 3%.
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