Aktivitas Analgesik Ekstrak Etanol Daun Kelengkeng (Dimocarpus longan L.) pada Mencit.
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Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
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Opra klasafle, Angga Bayu Budiyanto, Wahyuni Watora (2026). Aktivitas Analgesik Ekstrak Etanol Daun Kelengkeng (Dimocarpus longan L.) pada Mencit.. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1869
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Background: Pain is a physiological response indicating tissue disturbance or damage. Analgesics are used to alleviate pain; thus, developing analgesic sources from natural materials is essential. Longan leaves (Dimocarpus longan L.) contain secondary metabolites with potential pharmacological activity. Objective: This study aimed to evaluate the analgesic activity of the ethanolic extract of longan leaves and to determine the dose with the highest analgesic activity among the doses tested in male white mice. Methods: Longan leaves were extracted by maceration with 96% ethanol. Analgesic activity was assessed using the tail flick method in 25 male white mice divided into five groups (n=5): a positive control (sodium diclofenac), a negative control (Na-CMC), and the extract at 100, 200, and 400 mg/kg body weight. The change in tail flick latency (Δ, post-test minus pretest) was analyzed by one-way ANOVA followed by Tukey's post hoc test. Results: Phytochemical screening detected flavonoids, alkaloids, and saponins, whereas tannins, steroids, and terpenoids were not detected. The 400 mg/kg dose produced the highest increase in latency (Δ 4.88 ± 1.65 s at 120 minutes; latency 15.27 ± 2.38 s), which was significantly higher than the negative control (p<0.05) and not significantly different from sodium diclofenac (Δ 4.07 ± 0.81 s; p>0.05). The 200 mg/kg dose was comparable to sodium diclofenac at 30 and 60 minutes but lower at 90 and 120 minutes, whereas the 100 mg/kg dose did not differ from the negative control. Conclusion: The ethanolic extract of longan leaves has analgesic activity in male white mice, with the 400 mg/kg dose showing the highest activity among the doses tested. This activity is presumably associated with flavonoids, alkaloids, and saponins, which may reduce the formation of inflammatory mediators and influence pain transmission; this mechanism was not tested directly
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