Review: Identification of the main bioactive compounds in leilem leaves (Clerodendrum minahassae) and their pharmacological potential
Article metrics
OJS usage and citation sourcesViews and downloads are recorded by OJS; statistics processing may be delayed. A dash means the source count is unavailable. Search Google Scholar
Article Sidebar
Christel Nataniel Sambou (2024). Review: Identification of the main bioactive compounds in leilem leaves (Clerodendrum minahassae) and their pharmacological potential. Journal of Pharmaceutical and Sciences, JPS Volume 7 Nomor 4 (2024). https://doi.org/10.36490/journal-jps.com.v7i4.696
Main Article Content
Abstract
Clerodendrum minahassae leaves contain various bioactive compounds, including flavonoids, alkaloids, saponins, and phenolic acids, contributing to their pharmacological activity. This study aims to identify the main bioactive compounds in Leilem leaves (Clerodendrum minahassae) and their pharmacological potential through a literature review of various relevant scientific sources. The methodology employed includes systematic observation and meta-analysis. This review article describes the compounds present in Leilem leaves and evaluates their pharmacological activities, thereby enhancing the understanding of this underexplored medicinal plant. The findings indicate that Leilem leaves hold substantial potential as a source of bioactive molecules with diverse pharmacological properties. Based on a review of multiple scientific research articles, it can be concluded that Leilem leaves exhibit considerable efficacy in antimicrobial, anti-inflammatory, and antioxidant activities, as well as in reducing blood glucose levels.
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
How to Cite
References
Imrawati I, Utami YP, Hardianto H. Antioxidant Activity of Leilem Leaf Extract Fractions Clerodendrum Minahassae Teijsm. And Binn. Using the DPPH Method (2,2-Diphenyl-1-Picrylhydrazil). Int J Health Sci (Qassim) 2023;1:911–23. https://doi.org/10.59585/ijhs.v1i4.220.
Ogunlakin AD, Akinwumi IA, Ambali OA. Ethnomedicinal Application, Phytochemistry and Therapeutic Effects of Genus Clerodendrum. Functional Food Science 2023;3:228. https://doi.org/10.31989/ffs.v3i10.1151.
Fatimawali N, Tallei TE, Kepel BJ, Bodhi W, Manampiring AE, Nainu F. Molecular Insight Into the Pharmacological Potential of Clerodendrum Minahassae Leaf Extract for Type-2 Diabetes Management Using the Network Pharmacology Approach. Medicina (B Aires) 2023;59:1899. https://doi.org/10.3390/medicina59111899.
Gogoi B, Saikia SP. Virtual Screening and Network Pharmacology-Based Study to Explore the Pharmacological Mechanism of Clerodendrum Species for Anticancer Treatment. Evidence-Based Complementary and Alternative Medicine 2022;2022:1–17. https://doi.org/10.1155/2022/3106363.
Shendge AK, Basu T, Chaudhuri D, Panja S, Mandal N. In Vitro Antioxidant and Antiproliferative Activities of Various Solvent Fractions From Clerodendrum Viscosum Leaves. Pharmacogn Mag 2017;13:344. https://doi.org/10.4103/pm.pm_395_16.
Shekar BRC. Acute Central and Peripheral Analgesic Activity of Ethanolic Extract of the Leaves of Clerodendrum viscosum (Eecv) in Rodent Models. Journal of Drug Delivery and Therapeutics 2012;2. https://doi.org/10.22270/jddt.v2i5.255.
Kekuda TRP, shree V, Noorain GKS, Sahana BK, Raghavendra HL. Ethnobotanical Uses, Phytochemistry and Pharmacological Activities of Clerodendrum Infortunatum L. (Lamiaceae): A Review. Journal of Drug Delivery and Therapeutics 2019;9:547–59. https://doi.org/10.22270/jddt.v9i2.2433.
An AI, Omobolade O. Antimicrobial Activity of Clerodendrum Volubile (Marugbo) Leaves Against Selected Microbial Pathogens. International Journal of Research and Innovation in Applied Science 2021;06:121–5. https://doi.org/10.51584/ijrias.2021.6407
Bermula SJ, Maarisit W, Tombuku JL, Karauwan FA. Uji Aktivitas Antimikroba Ekstrak Etanol Daun Leilem Clerodendrum minahassae L. Terhadap Escherichia coli, Staphylococcus aureus, dan Candida albicans. Majalah InfoSains n.d.;2022:51–8.
Tumiir MS, Tiwow GAR, Karauwan FA, Palandi RR. Aktivitas Antiinflamasi Ekstrak Etanol Daun Leilem (Clerodendrum minahassae) Pada Tikus Putih (Rattus norvegicus) Yang Diinduksi Formalin. The Tropical Journal of Biopharmaceutical) n.d.;2021:74–9.
Rachmatiah T, Daud JJ, Artanti N. Aktivitas Antioksidan, Toksisitas, Kandungan Senyawa Fenol dan Flavonoid Total dari Daun Leilem (Clerodendrum minahassae Teijsm. & Binn) 2022;15.
Lengkong A G, Bodhi W, Syenni Datu O, Studi Farmasi FMIPA Universitas Sam Ratulangi P, Author C. Efek Ekstrak Etanol Daun Leilem (Clerodendrum Minahassae) Terhadap Kadar Glukos Darah Tikus Putih Jantan 2023;4.
David Pongsapan A, Kurniawan Prayoga D, Khoirotun Hisan A, Efata Glory Rambi S, Jaya Edy H, Sumantri Abdullah S. Uji Kandungan Dan Aktivitas Antioksidan Ekstrak Daun Leilem (Clerodendrum minahassae) Sebagai Kandidat Zat Aktif Sunscreen. vol. 7. 2024.
Rumondor R, Komalig MR, Kamaluddin K. Efek Pemberian Ekstrak Etanol Daun Leilem (Clerodendrum minahasae) terhadap Kadar Kreatinin, Asam Urat dan Ureum pada Tikus Putih (Rattus novergicus). Bio-Edu: Jurnal Pendidikan Biologi 2019;4:108–17. https://doi.org/10.32938/jbe.v4i3.419.
Madduluri S. RKB and SB. In Vitro Evaluation of Antibacterial Activity of Five Indigenous Plants Extracts against Five Bacteria Pathogens of Humans. 2013.
Ngajow M, Abidjulu J, Kamu VS. Pengaruh Antibakteri Ekstrak Kulit Batang Matoa (Pometia pinnata) terhadap Bakteri Staphylococcus aureus secara In vitro. J MIPA. 2013;2(2):128. https://doi.org/10.35799/jm.2.2.2013.3121
Nikham BTE 2012. Uji Bahan Baku Antibakteri dariBuah Mahkota Dewa (Phaleria Macrocarpa(Scheff) Boerl.) Hasil Iradiasi Gamma dan Antibiotik terhadap Bakteri Patogen. Serpong: Prosiding Pertemuan Ilmiah IlmuPengetahuan dan Teknologi Bahan.
Anak, Agung, Sagung, Krisna, Darmawati., I, Gusti, Agung, Gede, Bawa., I, Wayan, Suirta. Isolasi dan Identifikasi Senyawa Golongan Flavonoid pada Daun Nangka (Artocarpus heterophyllus Lmk) dan Aktivitas Antibakteri terhadap Staphylococcus aureus.2015;9:2.
Mehanna, A. S., 2003. NSAIDs: Chemistry and Pharmacological Actions. American Journal of Pharmaceutical Education 2003. 67:2. https://doi.org/10.5688/aj670263.
Yuhernita, Juniarti. Analisis Senyawa Metabolit Sekunder Dari Ekstrak Metanol Daun Surian Yang Berpotensi Sebagai Antioksidan. Makara, Sains 2011; 15:1.
Noviardi H, Yuningtyas S, Tri DA, Ben A. Toksisitas kombinasi ekstrak etanol 70% daun petai cina (Leucaena leucocephala (Lam.) de Wit) dan kulit jengkol (Archidendron jiringa(Jack) I.C.Nielsen) dengan metode Brine Shrimp Lethality Test. Riset Informasi Kesehatan 2019. 8:1. https://doi.org/10.30644/rik.v8i1.216
Kar P, Goyal AK, Das AP, Sen A..’ Antioxidant and Pharmaceutical Potential of Clerodendrum L.: An Overview, International Journal of Green Pharmacy 2014; 8:4.
Kairupan CF, Mantiri FR, Rumende RRH. ‘Phytochemical Screening and Antioxidant Activity of Ethanol Extract of Leilem (Clerodendrum minahassae Teijsm. & Binn) as an Antihyperlipidemic and Antiatherosclerotic Agent’, IOP Conf. Series: Earth and Environmental Science 2019;217. https://doi.org/10.1088/1755-1315/217/1/012016
Datu OS, Lebang JS, Suoth EJ.‘Efek Pemberian Ekstrak Buah Salahk (Salacca zalacca) dalam Menurunkan Kadar Glukosa Darah Pada Tikus Model Diabetes Melitus’. Jurnal MIPA 2022; 12:1. https://doi.org/10.35799/jm.v12i1.44267
Al-Ishaq RK, Abotaleb M, Kubatka P, Kajo K, Busselberg D. ‘Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels’. Biomolecules 2019; 9:430.