THE EFFECT OF STORAGE TEMPERATURE ON PHOSPATE CLINDAMYCIN STABILITY IN EMULGEL DOSAGE FORM WITH HIDROXYPROPYL METHYL CELLULOSE (HPMC) AS A GELLING AGENT
Article metrics
OJS usage and citation sourcesViews and downloads are recorded by OJS; statistics processing may be delayed. A dash means the source count is unavailable. Search Google Scholar
Article Sidebar
Yenni Sri Wahyuni, Erjon Erjon, Reza Aftarida (2019). THE EFFECT OF STORAGE TEMPERATURE ON PHOSPATE CLINDAMYCIN STABILITY IN EMULGEL DOSAGE FORM WITH HIDROXYPROPYL METHYL CELLULOSE (HPMC) AS A GELLING AGENT. Journal of Pharmaceutical and Sciences, Vol. 2 No. 2 (2019): JPS Volume 2 Nomor 2 (2019). https://doi.org/10.36490/journal-jps.com.v2i2.27
Main Article Content
Abstract
The present study was undertaken to investigate the effect of temperature on the degradation of clindamycin phosphate emulgel. This study aims to determine the rate of decomposition of clindamycin phosphate emulgel was storage at three different temperature of 30˚C, 50˚C, and 70˚C. Determination of percentage clindamycin phosphate was carried out every hour for 5 hours using Spectrophotometry UV-VIS. The results were statistically analyzed using the paired t-test. It was found a decrease in the levels of clindamycin phosphate emulgel at the storage temperature of 30˚C by 99.0874; 50˚C by 96.9314%, and a storage temperature of 70˚C by 96.0114%. Therefore, it can be said that clindamycin phosphate in emulgel preparations is chemically stable for 5 hours at a storage temperature of 30˚C, 50˚C, and 70˚C and the kinetics of the degradation rate of clindamycin phosphate in the emulgel preparation is in accordance with the second-order. Based on the statistically processed data result, it can be concluded that the storage temperature of 30˚C, 50˚C, and 70˚C shows that there is a significant difference (<0.005) in the data.
Article Details
Section
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
How to Cite
References
Agoes, G. (2001). Studi stabilitas sediaan farmasi. Bandung: Institut Teknologi Bandung.
Ansel, H.C. (1989). Pengantar Bentuk Sediaan Farmasi, (Edisi IV). Penerjemah: Ibrahim dan Farida, Universitas Indonesia, Jakarta.
Bhuyian, Md.H.U., Rasyid, Dr.H.A., Mohsin, Md., dan Tahera, K.T. (2015). An overview: stability study of pharmaceutical product and shelf life prediction. European of Biomedical Sciences, 2(6): 30-40.
Blessy M., Ruchi, D.P., Prajesh, N.P., dan Agrawal, Y.K. (2014). Development of forced degradation and stability indicating studies of drugs- a review. Journal of Pharmaceutical Analysis, 4(3): 159 - 165.
Fadli A., Mohammad, Nizam A.G., Ibrahim, A., Kavitha, M., Jiyauddin, K., Samer, A.D. . . ., dan Eddy, Y. (2015). Determination of permeation pathways of clindamycin phosphate into the skin. American Journal of Pharmtech Research, 5(2): 258-267.
Gupta, S., Dilip, K.C., dan Surabhi, R. (2017). Formulation and evaluation of clindamycin phosphate emulgel. Indo American Journal of Pharmaceutical Science, 4 (11): 4071-4077.
Harmita. (2006). Buku ajar analisa. Universitas Indonesia: Departemen Farmasi FMIPA.
Kementerian Kesehatan Republik Indonesia. (2014). Farmakope Indonesia (Edisi IV). Jakarta: Kementerian Kesehatan Republik Indonesia.
Lachman, L., Lieberman, H.A., dan Kanig, J.L. (2001). The theory and practice of industrial pharmacy. Philadelphia: LEA dan Febiger.
Magari, Robert T. (2003). Assessing shelf life using real-time and accelerated stability test. Biopharm International,16(11).
Oesterling, T.O. (1970). Aqueous stability of clindamycin. J Pharm Sci, 63-67.
Sinko, Patrick J. (2008). Martin farmasi fisik dan ilmu farmasetika (Edisi V). Jakarta: Penerbit Buku Kedokteran EGC.
Sweetman, S.C. (2009). Martindale. (Edisi XXXVI). London: Pharmaceutical Press.
Vadas, E.B. (2000). Stability of pharmaceutical product, dalam Gannero, A.R., Ed Remington: The science and practice of pharmacy, 20th edition, Lipincott, Wilkins, Phildemia, Chap52.
Victory, R. (2019). Formulasi dan evaluasi emulgel klindamisin fosfat dengan variasi HPMC sebagai gelling agent serta aktivitas daya hambat bakteri. Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi, Palembang.
Yoshioka, Sumie dan Valentino, J.S. (2002). Stability of drugs and dosage forms. Kluwer Academic Publisher, 4-12. Retrieved from https://link.springer.com/book/10.1007/b114443