Determination of Zinc Sulfat Content in Zinc Sulfat Monohydrate Tablets available on the Market Using the Complexometric Titration Method
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Athifa Carca Fikri, Andi Suhendi, Ika Trisharyanti Dian Kusumowati (2026). Determination of Zinc Sulfat Content in Zinc Sulfat Monohydrate Tablets available on the Market Using the Complexometric Titration Method . Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1851
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Abstract
Introduction: Zinc is an essential mineral that plays an important role in various physiological functions, therefore, quality control of zinc supplement preparations available on the market is necessary. Objective: This study aims to determine the zinc sulfate content in commercially available tablets using a complexometric titration method and to evaluate the accuracy, precision, and content uniformity of four generic tablets in Indonesia as part of quality control efforts to ensure compliance with established standards. Methods: An experimental study was conducted on four brands of zinc sulfate tablets using standardized EDTA solutions. The standardization result shows an EDTA concentration of 0,099 M. Method evaluation included accuracy testing using the standard addition method at 80%, 100%, and 120% levels, with the result showing a recovery range of 98-102%, while the precision was evaluated based on the Relative Standard Deviation (RSD), yielding a %RSD value of 0,343%. Result: All four tablet brands met the USP assay requirements, which specify a range of 95-105%. The content uniformity test also met the requirements, with an Acceptance Value below 15. Conclusion: Therefore, all samples complied with the quality requirements, indicating that complexometric titration using EDTA can be applied for the determination of zinc content in tablet preparation.
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