Correlation of ETDQ-7 with Eustachian Tube Function Testing and Tympanometry in Nasopharyngeal Carcinoma Patients After Chemoradiotherapy
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Pandu Wicaksono, Ahmad Nurdiansyah, Dewi Pratiwi, Balqis Kartika Murti, Raymond Rheza, Aviaddina Ramadhani, Desnita Monica (2026). Correlation of ETDQ-7 with Eustachian Tube Function Testing and Tympanometry in Nasopharyngeal Carcinoma Patients After Chemoradiotherapy. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 4 (2026). https://doi.org/10.36490/journal-jps.com.v9i4.1792
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Abstract
Disfungsi tuba Eustachius sering terjadi pada pasien karsinoma nasofaring (KNF), terutama setelah kemoradiasi. Disfungsi tuba setelah kemoradiasi disebabkan oleh kombinasi obstruksi dan gangguan fungsional sehingga penilaian fungsi tuba Eustachius sangatlah penting. Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) adalah kuesioner singkat tervalidasi untuk menandai adanya risiko disfungsi tuba Eustachius. Penelitian ini bertujuan menilai asosiasi antara skor ETDQ-7 dengan hasil pemeriksaan fungsi tuba Eustachius (Eustachian Tube Function Test [ETF]) dan timpanometri pada pasien karsinoma nasofaring pasca kemoradioterapi. Penelitian ini menggunakan desain analitik cross-sectional di poliklinik THT-BKL pada periode Februari hingga Mei 2026. Penilaian disfungsi tuba Eustachius menggunakan ETDQ-7 dengan cut-off ≥3, kemudian dibandingkan dengan pemeriksaan ETF dan timpanometri. Hubungan antarvariabel dianalisis menggunakan uji Fisher-Exact. Sebanyak 66 pasien diikutsertakan dengan rerata usia 58,08±8,71 tahun, mayoritas laki-laki (75,8%). Berdasarkan ETDQ-7, 56,1% pasien mengalami DTE derajat sedang dan 15,2% derajat berat. Terdapat hubungan bermakna antara ETF dan ETDQ-7 (p<0,001; CC 0,583; Cramér's V 0,717; IK 95% 0,546–0,803) serta antara timpanometri dan ETDQ-7 (p<0,001; CC 0,620; Cramér's V 791; IK 95% 0,673–0,864), dengan kekuatan hubungan timpanometri yang lebih tinggi dibandingkan ETF. Disfungsi tuba Eustachius masih sering ditemukan pada pasien KNF pasca kemoradioterapi. Skor ETDQ-7 memiliki hubungan yang signifikan dengan hasil pemeriksaan ETF dan timpanometri, sehingga berpotensi digunakan sebagai metode skrining awal yang sederhana dan mudah diaplikasikan untuk mendeteksi disfungsi tuba Eustachius pada pasien KNF pasca kemoradiasi.
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[1] Anand V, Poe D, Dean M, Roberts W, Stolovitzky P, Hoffmann K, et al. Balloon dilation of the Eustachian tube: extended follow-up results. Otolaryngol Head Neck Surg. 2020;163(2):312-318.
[2] Cutler JL, Meyer TA, Nguyen SA, O’Malley EM, Thackeray L, Slater PW. Long-term outcomes of balloon dilation for Eustachian tube dysfunction. Otol Neurotol. 2021;42(5):e567-e573.
[3] Formanek M, Formankova D, Skoloudik L, Zelenik K, Chrobok V, Kominek P. Balloon Eustachian tuboplasty outcomes in adults: prospective study. Ear Nose Throat J. 2020;99(9):579-585.
[4] Huang Q, Luo J, Li Y, Chen L. Assessment of Eustachian tube function in post-radiotherapy nasopharyngeal carcinoma. BMC Cancer. 2021;21:987.
[5] Li W, Li H, Chen Y, Wang J. Eustachian tube dysfunction after radiotherapy in nasopharyngeal carcinoma. Head Neck. 2022;44(3):654-661.
[6] Luukkainen V, Kivekas I, Silvola J, Jero J, Sinkkonen ST. Long-term outcomes of balloon Eustachian tuboplasty. J Int Adv Otol. 2020;16(2):198-204.
[7] McCoul ED, Anand VK, Christos PJ. Validity and reliability of ETDQ-7 in clinical practice. Laryngoscope Investig Otolaryngol. 2021;6(3):451-456.
[8] Meyer TA, O’Malley EM, Schlosser RJ, Soler ZM, Cai J, Hoy MJ, et al. Balloon dilation as treatment for persistent Eustachian tube dysfunction: 2-year outcomes. Otol Neurotol. 2020;41(9):1322-1329.
[9] Indrasari SR, Dewi YA, Luetta NA, Romdhoni AC, Nuaba IGA, Herawati C, et al. Epidemiological and clinical profile of nasopharyngeal carcinoma in Indonesia: a nationwide descriptive study. Int J Biomed. 2025;15(3):517-522.
[10] Bal R, Deshmukh P. Management of Eustachian tube dysfunction: a review. Cureus. 2022;14(11):e31432.
[11] Chua NYM, Chan YH, Loh WS, Wang DY. Radiotherapy-induced otitis media with effusion in nasopharyngeal carcinoma: a meta-analysis. The Laryngoscope, 10.1002/lary.70535. Advance online publication.
[12] Jiang M, Li H, Chen C, Li Y, Zou X. Postirradiation otitis media with effusion in nasopharyngeal carcinoma: a comprehensive review of pathogenesis, management, and prevention. Int J Radiat Oncol Biol Phys. 2025;123(4):1018-1034.
[13] Kaneko T, Koto M, Ikawa H, Shinoto M, Takiyama H, Yamada S, et al. Dosimetric analysis for otitis media with effusion due to Eustachian tube dysfunction after carbon-ion radiation therapy for head and neck cancers. Adv Radiat Oncol. 2023;8(1):101115.
[14] Moon S, Lee Y, Jung J, Moon IS, Bae SH. Association between Eustachian Tube Dysfunction Questionnaire-7 scores and Eustachian tube function test results in symptomatic patients with a normal drum. J Audiol Otol. 2022;26(3):142-146.
[15] Restuti RD, Sriyana AA, Priyono H, Saleh RR, Alviandi W. Validity and reliability of Eustachian Tube Dysfunction Questionnaire (ETDQ-7) adaptation in Bahasa Indonesia. ORLI. 2023;53(1):7-14.
[16] Alper CM, Teixeira MS, Mandel EM, Swarts JD. Dissecting eustachian tube dysfunction: from phenotypes to endotypes. PLoS One. 2023;18(4):e0283885.
[17] Wong MSL, Prepageran N. Preliminary results of a pilot study on the safety and efficacy of balloon dilatation of the Eustachian tube for nasopharyngeal cancer patients with chronic Eustachian tube dysfunction post irradiation. J Laryngol Otol. 2021;135(8):691-694.
[18] Alkholaiwi F, Alnatheer AM, Theyab RS, Alyousef M, Aldrees T, Dahmash AB, et al. Cross-cultural adaptation, validation, and Arabic translation of the Eustachian Tube Dysfunction Questionnaire (ETDQ-7). Int Arch Otorhinolaryngol. 2022;26(4):e636-e642.