Synthesis and Characterization of Gardenia Essential Oil Nanoparticles Using a PEG-40 Hydrogenated Castor Oil Protective Polymer Layer
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Abstract
This study focused on the preparation of Gardenia essential oil nanoemulsions using PEG-40 Hydrogenated Castor Oil (PEG-40 HCO) as a surfactant through an atomization method to evaluate the effect of oil concentration on the physical characteristics and electrokinetic properties of the resulting system. Four oil volumes, namely 4, 6, 8, and 10 mL in 80 mL of water, were used as precursors and subsequently analyzed to determine particle size, polydispersity index (PDI), electrophoretic mobility, and zeta potential. The results showed that increasing oil concentration tended to increase the average particle diameter. The obtained PDI values were relatively low; however, their interpretation was conducted cautiously because the system exhibited a bimodal particle size distribution. The zeta potential values ranged from −2.3 to −7.8 mV, while the electrophoretic mobility values ranged from −0.000017 to −0.000060 cm²/Vs. These results indicate changes in particle surface characteristics with increasing essential oil concentration. The characteristics of the resulting nanoemulsion suggest that PEG-40 HCO plays a role in the formation and dispersion of oil droplets in an aqueous medium. Overall, the findings indicate that PEG-40 HCO has potential for the preparation of Gardenia essential oil nanoemulsions with particle sizes in the nanometer range and relatively favorable size distribution characteristics, making them promising for further development in water-based perfume formulations and other cosmetic applications. However, the long-term stability of the system still requires further stability evaluation.
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References
Herdiana Y. Alcohol in Daily Products: Health Risks, Cultural Considerations, and Economic Impacts. Risk Manag Healthc Policy 2025;Volume 18:217–37. https://doi.org/10.2147/RMHP.S495493.
Sabrina LM, Zahra AA, Aini KN, Rafifa M, Maulida VS, Putra HE. Analisis Komparatif Surfaktan dan Kosurfaktan serta Parameter Fisik Dalam Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Berbasis Tanaman Herbal. Jurnal Ilmiah Respati 2025;16:63–74.
Adeyemi SB, Akere AM, Orege JI, Ejeromeghene O, Orege OB, Akolade JO. Polymeric nanoparticles for enhanced delivery and improved bioactivity of essential oils. Heliyon 2023;9:e16543. https://doi.org/10.1016/j.heliyon.2023.e16543.
Buriti BMA de B, Figueiredo PLB, Passos MF, da Silva JKR. Polymer-Based Wound Dressings Loaded with Essential Oil for the Treatment of Wounds: A Review. Pharmaceuticals 2024;17:897. https://doi.org/10.3390/ph17070897.
Winarti RS, Saragih H. Pengaruh Penyimpanan dan Pemanasan Terhadap Perubahan Ukuran Nanopartikel Parfum Campuran Minyak Royal Musk dan Minyak Atsiri Lili yang Disintesis Menggunakan Surfaktan Polimer PEG-40 HCO. Jurnal Fisika Unand 2025;14:516–25. https://doi.org/10.25077/jfu.14.5.516-525.2025.
Kumar M, Chauhan N, Kumar D, Mahmood S, Chopra S, Bhatia A. Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond. J Dispers Sci Technol 2024:1–26. https://doi.org/10.1080/01932691.2024.2369835.
Jacob S, Kather FS, Boddu SHS, Shah J, Nair AB. Innovations in Nanoemulsion Technology: Enhancing Drug Delivery for Oral, Parenteral, and Ophthalmic Applications. Pharmaceutics 2024;16:1333. https://doi.org/10.3390/pharmaceutics16101333.
Rachmawati H, Novel M, Ayu S, Berlian G, Tandrasasmita O, Tjandrawinata R, et al. The In Vitro–In Vivo Safety Confirmation of PEG-40 Hydrogenated Castor Oil as a Surfactant for Oral Nanoemulsion Formulation. Sci Pharm 2017;85:18. https://doi.org/10.3390/scipharm85020018.
Daneshmand H, Sazgar A, Araghchi M. Fabrication of robust and versatile superhydrophobic coating by two-step spray method: An experimental and molecular dynamics simulation study. Appl Surf Sci 2021;567:150825. https://doi.org/10.1016/j.apsusc.2021.150825.
Marquez R, Ontiveros JF, Barrios N, Tolosa L, Palazzo G, Nardello‐Rataj V, et al. Advantages and limitations of different methods to determine the optimum formulation in surfactant–oil–water systems: A review. J Surfactants Deterg 2024;27:5–36. https://doi.org/10.1002/jsde.12703.
Singh PK, Joshi D, Mandal A, Pal N. Silica Nanoparticle-Stabilized Anionic Surfactant Microemulsions: Characterization, Technical Evaluation, and Core-Flooding Studies for Enhanced Oil Recovery. Energy & Fuels 2025;39:1870–88. https://doi.org/10.1021/acs.energyfuels.4c05091.
Goswami AS, Rawat R, Pillai P, Saw RK, Joshi D, Mandal A. Formulation and characterization of nanoemulsions stabilized by nonionic surfactant and their application in enhanced oil recovery. Pet Sci Technol 2024;42:2990–3008. https://doi.org/10.1080/10916466.2023.2181357.
Putra AAGSP, Suhendra L, IAnggreni AAMD. Stabilitas Dan Ukuran Partikel Mikroemulsi Minyak Atsiri Sereh (Cymbopogon Citratus) Dengan Rasio Surfaktan Dan Ko-Surfaktan. JURNAL REKAYASA DAN MANAJEMEN AGROINDUSTRI 2025;13:196–204. https://doi.org/10.24843/JRMA.2025.v13.i02.p05.
Kurchavov D, Rustambek U, Haddad M, Ottochian A, Lefèvre G, Ciofini I, et al. Influence of PEG-containing cation on molecular state of water in water – Acetate based ionic liquids mixtures. J Mol Liq 2022;367:120564. https://doi.org/10.1016/j.molliq.2022.120564.
Pochapski DJ, Carvalho dos Santos C, Leite GW, Pulcinelli SH, Santilli CV. Zeta Potential and Colloidal Stability Predictions for Inorganic Nanoparticle Dispersions: Effects of Experimental Conditions and Electrokinetic Models on the Interpretation of Results. Langmuir 2021;37:13379–89. https://doi.org/10.1021/acs.langmuir.1c02056.
Hunter SJ, Penfold NJW, Chan DH, Mykhaylyk OO, Armes SP. How Do Charged End-Groups on the Steric Stabilizer Block Influence the Formation and Long-Term Stability of Pickering Nanoemulsions Prepared Using Sterically Stabilized Diblock Copolymer Nanoparticles? Langmuir 2020;36:769–80. https://doi.org/10.1021/acs.langmuir.9b03389.
Tran E, Richmond GL. Interfacial Steric and Molecular Bonding Effects Contributing to the Stability of Neutrally Charged Nanoemulsions. Langmuir 2021;37:12643–53. https://doi.org/10.1021/acs.langmuir.1c02020.
Artiga-Artigas M, Montoliu-Boneu J, Salvia-Trujillo L, Martín-Belloso O. Factors affecting the formation of highly concentrated emulsions and nanoemulsions. Colloids Surf A Physicochem Eng Asp 2019;578:123577. https://doi.org/10.1016/j.colsurfa.2019.123577.
Dajic Stevanovic Z, Sieniawska E, Glowniak K, Obradovic N, Pajic-Lijakovic I. Natural Macromolecules as Carriers for Essential Oils: From Extraction to Biomedical Application. Front Bioeng Biotechnol 2020;8. https://doi.org/10.3389/fbioe.2020.00563.
Aisyah N, Sriwidodo S, Husni P, Sinala S. Analisis Aktivitas Antioksidan Nanoemulsi Berbaris Tanaman dalam Aplikasi Farmasi dan Kosmetik : Kajian Literatur. Media Kesehatan Politeknik Kesehatan Makassar 2025;20:139–52. https://doi.org/10.32382/medkes.v20i1.1458.