Evaluasi in vitro dan in silico aktivitas toksikologi dan anti proliferasi senyawa fitokimia beberapa ekstrak pelarut dari Zaleya Pentandra L
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Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
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Mohamed O. Elsamani (2024). Evaluasi in vitro dan in silico aktivitas toksikologi dan anti proliferasi senyawa fitokimia beberapa ekstrak pelarut dari Zaleya Pentandra L. Journal of Pharmaceutical and Sciences, JPS Volume 7 Nomor 1 (2024). https://doi.org/10.36490/journal-jps.com.v7i1.404
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Tanaman obat dan herbal merupakan sumber nutrisi unggul yang penting, terutama digunakan dalam makanan dan untuk mengobati berbagai penyakit. Tujuan: Tujuan utama dari penelitian ini adalah untuk mengetahui senyawa fitokimia, aktivitas antioksidan dan antibakteri pada lima ekstrak Zaleya pentandra (ZPE), etanol, heksana, aseton, etil asetat, dan metanol, untuk pertama kalinya. Metode: dilakukan dengan menggunakan HPLC-MS, pengukuran dilakukan sebanyak tiga kali ulangan. Hasil: ekstrak paling signifikan, mengungkapkan 13 senyawa, yang tampak memiliki kandungan lebih tinggi (417,5±0,44 μg/g dan (407,5±0,04 μg/g), nilai ZPE pada total β-Sitosterol dan dioctylphthalate, serta kandungan total polifenol (TPC) secara signifikan (p≤0,05) lebih tinggi terutama pada aseton (323,06±1,74mg GAE/g), etil asetat (220 ± 1,00) mg GAE/g), dan ekstrak herbal heksana (75,2±1,70) mg QE/g) dengan perbedaan yang signifikan (P≤0,05) terhadap total kandungan flavonoid. Diskusi: semua strain bakteri yang diselidiki, dengan efek yang sangat tinggi terhadap B. subtilis. Senyawa yang signifikan memiliki potensi menjadi senyawa obat dikualifikasikan melalui analisis komputasi yang mencakup penilaian toksikologi dan farmakokinetik. Ekstrak aseton Zaleya pentandra merupakan farksi yang potensial sebagai senyawa antibakteri baru. Kesimpulan: penelitian ini menawarkan informasi baru mengenai penerapan ZPE dalam agen terapi baru dan berpotensi efektif, penerapannya dalam industri makanan dan pengobatan berbagai penyakit.
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