Determinan Perilaku Kepatuhan Minum Obat pada Pasien Hipertensi Usia Produktif di Pelayanan Kesehatan Primer: Scoping Review
Statistik artikel
Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
Bilah Samping Artikel
Kusniawati, Herawati, Didik Dwi Sanyoto, Oski Illiandri, Syamsul Arifin (2026). Determinan Perilaku Kepatuhan Minum Obat pada Pasien Hipertensi Usia Produktif di Pelayanan Kesehatan Primer: Scoping Review. Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 2 (2026). https://doi.org/10.36490/journal-jps.com.v9i2.1483
Isi Artikel Utama
Abstrak
Latar Belakang: Hipertensi merupakan masalah kesehatan global utama dan faktor risiko penting penyakit kardiovaskular. Meskipun obat antihipertensi tersedia secara luas, kepatuhan minum obat masih menjadi tantangan utama dalam mencapai pengendalian tekanan darah yang optimal, khususnya pada pasien usia produktif. Tujuan: Scoping review ini bertujuan untuk mengidentifikasi dan mensintesis bukti ilmiah mengenai determinan perilaku kepatuhan minum obat pada pasien hipertensi usia produktif (18–59 tahun) di pelayanan kesehatan primer. Metode: Review ini mengikuti kerangka Joanna Briggs Institute (JBI) dan pedoman PRISMA-ScR. Pencarian literatur dilakukan pada basis data PubMed, Scopus, ScienceDirect, dan Google Scholar untuk artikel yang dipublikasikan pada tahun 2016–2026. Studi yang melibatkan partisipan usia produktif (18–59 tahun) dan membahas determinan kepatuhan terhadap obat antihipertensi dimasukkan ke dalam ulasan. Hasil: Sebanyak 14 studi memenuhi kriteria inklusi. Hasil kajian menunjukkan bahwa kepatuhan pengobatan pada pasien hipertensi usia produktif dipengaruhi oleh berbagai faktor, yaitu karakteristik sosiodemografi (usia, pendidikan, status ekonomi), efikasi diri, literasi kesehatan, faktor terkait terapi (kompleksitas regimen, efek samping), dukungan sistem pelayanan kesehatan (komunikasi efektif, konseling), dukungan sosial, serta intervensi kesehatan digital (aplikasi seluler, pengingat elektronik). Kesimpulan: Perilaku kepatuhan minum obat pada pasien hipertensi usia produktif bersifat multidimensional. Diperlukan strategi komprehensif dan terintegrasi yang mencakup edukasi pasien, peningkatan efikasi diri dan literasi kesehatan, penyederhanaan regimen terapi, penguatan komunikasi tenaga kesehatan, serta pemanfaatan intervensi berbasis teknologi untuk meningkatkan kepatuhan jangka panjang dan pengendalian tekanan darah.
Rincian Artikel
Terbitan
Bagian
Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Cara Mengutip
Referensi
Hannan N, Ruslan NA, Zaini S, Mizher AA. Mobile Application Intervention Effectiveness in Improving Hypertensive Patients' Medication Adherence : A Systematic Review. 2025;5:115–31.
Thalib A. Hypertension Causes, Impacts, and Control Strategies In The Modern Era. 2025;2(February):12–9.
Ribó-Coll M, Lassale C, Sacanella E, Ros E, Toledo E, Sorlí J V, et al. Mediterranean diet and antihypertensive drug use: a randomized controlled trial. J Hypertens [Internet]. 2021;39(6). Available from: https://journals.lww.com/jhypertension/fulltext/2021/06000/mediterranean_diet_and_antihypertensive_drug_use_.25.aspx
Palmer MJ, Barnard S, Perel P, Free C. Mobile phone‐based interventions for improving adherence to medication prescribed for the primary prevention of cardiovascular disease in adults. Cochrane Database Syst Rev [Internet]. 2017;(5). Available from: https://doi.org//10.1002/14651858.CD012675
Boima V, Doku A, Agyekum F, Tuglo LS, Agyemang C. Effectiveness of digital health interventions on blood pressure control, lifestyle behaviours and adherence to medication in patients with hypertension in low-income and middle-income countries: a systematic review and meta-analysis of randomised controlled trials. EClinicalMedicine. 2024 Mar;69:102432.
Duncan MJ, Vandelanotte C, Caperchione C, Hanley C, Mummery WK. Temporal trends in and relationships between screen time, physical activity, overweight, and obesity. BMC Public Health [Internet]. 2012;12(1):1060. Available from: https://doi.org/10.1186/1471-2458-12-1060
Mebrahtu G, Moleki M, Achila O, Seyoum Y, Adgoy E, Ovberedjo M. Antihypertensive Medication Adherence and Associated Factors: A Cross-Sectional Analysis of Patients Attending a National Referral Hospital in Asmara, Eritrea. Patient Prefer Adherence. 2021 Nov 23;15:2619–32.
Schiffrin EL. The Year in Clinical Hypertension From Other Pages. Am J Hypertens [Internet]. 2018 Jan 12;31(2):136–8. Available from: https://doi.org/10.1093/ajh/hpx206
A AP, Fajriansi A. Medication Adherence, Glycemic Control, and Quality of Life Among Patients with Type 2 Diabetes Mellitus at a Primary Health Center in Makassar, Indonesia. 2026;3(February):32–9.
Kilic HF. The Relationship between Health Literacy and Medication Adherence in a Hypertensive Patient Population. 2020;13(1):101–7.
Aprahamian I, Sassaki E, dos Santos MF, Izbicki R, Pulgrossi RC, Biella MM, et al. Hypertension and frailty in older adults. J Clin Hypertens [Internet]. 2018 Jan 1;20(1):186–92. Available from: https://doi.org/10.1111/jch.13135
Tedla YG, Bautista LE. Drug Side Effect Symptoms and Adherence to Antihypertensive Medication. Am J Hypertens [Internet]. 2016 Jun 1;29(6):772–9. Available from: https://doi.org/10.1093/ajh/hpv185
Ajayi DT, Adedokun BO, Owoeye DO, Akpa OM. Treatment Satisfaction and Medication Adherence Among Hypertensive Patients Seeking Care in Selected Hospitals in Ibadan, Nigeria. Arch basic Appl Med. 2018 Feb;6(1):67–72.
Sabiti FB, Fatiha CN, Timur WW, Dewi PA. Pengaruh Konseling Apoteker terhadap Kepatuhan Obat dan Nilai Tekanan Darah pada Pasien Hipertensi (The Effect of Pharmacist Counseling on Medication Adherence and Blood Pressure Values in Hypertensive Patients). 2023;20(2):151–7.
Thirunavukkarasu A, Naser Abdullah Alshahrani A, Mazen Abdel-Salam D, Homoud Al-Hazmi A, Farhan Alruwaili B, Awad Alsaidan A, et al. Medication Adherence Among Hypertensive Patients Attending Different Primary Health Centers in Abha, Saudi Arabia: A Cross-Sectional Study. Patient Prefer Adherence. 2022;16:2835–44.
Zhang Z, Cajochen C, Khatami R. Social Jetlag and Chronotypes in the Chinese Population : Analysis of Data Recorded by Wearable Devices Corresponding Author : 2019;21(6).
Dai L, Song L, Li X, Yang Y, Zheng X, Wu Y, et al. Association of visit-to-visit blood pressure variability with the risk of all-cause mortality and cardiovascular events in the general population. J Clin Hypertens [Internet]. 2018 Feb 1;20(2):280–8. Available from: https://doi.org/10.1111/jch.13192
Turan GB, Aksoy M, Çiftçi B. Effect of social support on the treatment adherence of hypertension patients. J Vasc Nurs Off Publ Soc Peripher Vasc Nurs. 2019 Mar;37(1):46–51.
Pristianty L, Hingis ES, Priyandani Y, Rahem A. Relationship between knowledge and adherence to hypertension treatment. J Public Health Africa. 2023 Mar;14(Suppl 1):2502.
Wrigley C, Straker K, Nusem E, Fraser JF, Gregory SD. Nursing Challenges in Interactions With Patients Receiving Mechanical Circulatory and Respiratory Support. J Cardiovasc Nurs [Internet]. 2018;33(5). Available from: https://journals.lww.com/jcnjournal/fulltext/2018/09000/nursing_challenges_in_interactions_with_patients.17.aspx
Lockwood C, dos Santos KB, Pap R. Practical Guidance for Knowledge Synthesis: Scoping Review Methods. Asian Nurs Res (Korean Soc Nurs Sci) [Internet]. 2019;13(5):287–94. Available from: https://doi.org/10.1016/j.anr.2019.11.002
Peters, M. D., Godfrey, C. M., McInerney, P., Soares, C. B., Khalil, H., & Parker, D. The Joanna Briggs Institute Reviewers. Manual 2015: Methodology for JBI scoping reviews. Joanne Briggs Inst [Internet]. 2015;1–24. Available from: http://joannabriggs.org/assets/docs/sumari/ReviewersManual_Mixed-Methods-Review-Methods-2014-ch1.pdf
Liu F, Chang H, Liu X. Adherence Behaviors and Related Factors Among Elderly Hypertensive Patients in China: Evidence from the China Health and Retirement Longitudinal Study. Patient Prefer Adherence. 2023;17:3539–53.
Turki F. Medication Adherence, Blood Pressure Control, Knowledge, Self-care, and Self-efficacy among Tunisian Hypertensive Patients. 2024;1–10.
Khan G, Thapa R, Khakurel A, Shrestha G, Katila N, Bhurtel S. Medication Adherence and Blood Pressure Control among Hypertensive Patients of Pokhara Valley. J Heal Allied Sci. 2019 Nov 24;3:64–7.
Pallangyo P, Komba M, Mkojera ZS, Kisenge PR, Bhalia S, Mayala H, et al. Medication Adherence and Blood Pressure Control Among Hypertensive Outpatients Attending a Tertiary Cardiovascular Hospital in Tanzania: A Cross-Sectional Study. Integr Blood Press Control. 2022;15:97–112.
Márquez Contreras E, Márquez Rivero S, Rodríguez García E, López-García-Ramos L, Carlos Pastoriza Vilas J, Baldonedo Suárez A, et al. Specific hypertension smartphone application to improve medication adherence in hypertension: a cluster-randomized trial. Curr Med Res Opin. 2019 Jan;35(1):167–73.
Berhe DF, Taxis K, Haaijer-Ruskamp FM, Mulugeta A, Mengistu YT, Burgerhof JGM, et al. Impact of adverse drug events and treatment satisfaction on patient adherence with antihypertensive medication - a study in ambulatory patients. Br J Clin Pharmacol. 2017 Sep;83(9):2107–17.
Eaton CK, Eakin MN, Coburn S, Pruette CS, Brady TM, Fivush BA, et al. Patient Health Beliefs and Characteristics Predict Longitudinal Antihypertensive Medication Adherence in Adolescents With CKD. J Pediatr Psychol. 2019 Jan;44(1):40–51.
Delavar F, Pashaeypoor S, Negarandeh R. The effects of self-management education tailored to health literacy on medication adherence and blood pressure control among older adults with primary hypertension: A randomized controlled trial. Patient Educ Couns. 2020 Feb;103(2):336–42.
Tavakoly Sany SB, Peyman N, Behzhad F, Esmaeily H, Taghipoor A, Ferns G. Health providers' communication skills training affects hypertension outcomes. Med Teach. 2018 Feb;40(2):154–63.
Kristina S, Dewi P, Widiastuti W. Effectiveness Of Counseling For Hypertensive Patients On Adherence And Blood Pressure Outcome In Primary Care Providers in Indonesia. Int Res J Pharm. 2019 Aug 2;10:40–4.
Kassavou A, Houghton V, Edwards S, Brimicombe J, Sutton S. Development and piloting of a highly tailored digital intervention to support adherence to antihypertensive medications as an adjunct to primary care consultations. BMJ Open. 2019 Jan;9(1):e024121.
Sulfikar A, Rajab MA. Evaluation of the feasibility of digital health applications based on best practice guidelines for diabetes management: A scoping review. Informatics Med Unlocked [Internet]. 2024;51:101601. Available from: https://www.sciencedirect.com/science/article/pii/S2352914824001588
Arshed M, Mahmud A, Minhat HS, Lim PY, Zakar R. Effectiveness of a Multifaceted Mobile Health Intervention (Multi-Aid-Package) in Medication Adherence and Treatment Outcomes Among Patients With Hypertension in a Low- to Middle-Income Country: Randomized Controlled Trial. JMIR mHealth uHealth. 2024 Jun;12:e50248.
Burnier M, Egan BM. Adherence in Hypertension. Circ Res [Internet]. 2019 Mar 29;124(7):1124–40. Available from: https://doi.org/10.1161/CIRCRESAHA.118.313220
Del Pinto R, Wright JT, Monaco A, Pietropaoli D, Ferri C. Vitamin D and blood pressure control among hypertensive adults: results from NHANES 2001–2014. J Hypertens [Internet]. 2020;38(1). Available from: https://journals.lww.com/jhypertension/fulltext/2020/01000/vitamin_d_and_blood_pressure_control_among.22.aspx
Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol [Internet]. 2012 May 1;73(5):691–705. Available from: https://doi.org/10.1111/j.1365-2125.2012.04167.x
Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum A, et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013 Sep;310(9):959–68.
Bandura, A. Self-efficacy: The exercise of control. Macmillan, 1997.
Ni Z, Liu C, Wu B, Yang Q, Douglas C, Shaw RJ. An mHealth intervention to improve medication adherence among patients with coronary heart disease in China: Development of an intervention. Int J Nurs Sci [Internet]. 2018;5(4):322–30. Available from: https://www.sciencedirect.com/science/article/pii/S2352013218300838
Osborn CY, Cavanaugh K, Wallston KA, Kripalani S, Elasy TA, Rothman RL, et al. Health Literacy Explains Racial Disparities in Diabetes Medication Adherence. J Health Commun [Internet]. 2011 Sep 30;16(sup3):268–78. Available from: https://doi.org/10.1080/10810730.2011.604388
DiMatteo MR. Social support and patient adherence to medical treatment: a meta-analysis. Heal Psychol Off J Div Heal Psychol Am Psychol Assoc. 2004 Mar;23(2):207–18.
Yang Q, Tai-seale M, Liu S, Shen Y, Zhang X, Xiao X. Measuring Public Reaction to Violence Against Doctors in China : Interrupted Time Series Analysis of Media Reports Corresponding Author : 2021;23:1–14.