Profil Oral Hygiene Index–Simplified (OHI‑S) dan Kadar Interleukin‑1β Saliva sebagai Biomarker Inflamasi pada Pasien dengan Gingivitis
Statistik artikel
Data OJS dan sumber sitasiTayangan dan unduhan adalah aktivitas yang tercatat di OJS; pemrosesan statistik dapat tertunda. Tanda — berarti angka dari sumber tersebut belum tersedia. Cari di Google Scholar
Isi Artikel Utama
Abstrak
Pendahuluan: Gingivitis merupakan tahap awal penyakit periodontal yang disebabkan oleh akumulasi plak dan ditandai dengan inflamasi gingiva, dengan interleukin‑1β (IL‑1β) saliva berperan sebagai biomarker inflamasi kunci. Namun, studi yang secara spesifik mengkaji hubungan antara status kebersihan mulut dan kadar IL‑1β saliva pada remaja dengan gingivitis masih terbatas di populasi Indonesia. Tujuan: Penelitian ini bertujuan untuk mendeskripsikan profil Oral Hygiene Index–Simplified (OHI‑S) dan kadar IL‑1β saliva, serta menganalisis hubungan keduanya pada pasien gingivitis remaja. Metode: Studi potong lintang dilakukan pada 36 pasien gingivitis usia 15–18 tahun di Kota Padang yang dipilih secara purposive. Status kebersihan mulut dinilai menggunakan OHI‑S, sedangkan kadar IL‑1β saliva diukur dari saliva tidak terstimulasi dengan metode ELISA. Data dianalisis secara univariat dan bivariat menggunakan uji korelasi Pearson dengan tingkat kemaknaan p<0,05. Hasil: Rerata usia responden adalah 15,97±1,03 tahun, dengan mayoritas termasuk remaja pertengahan (15 tahun). Hanya 8,3% subjek memiliki OHI‑S baik, sedangkan 66,7% berada pada kategori sedang dan 25% buruk, menunjukkan akumulasi plak dan kalkulus yang signifikan. Terdapat korelasi positif sedang dan bermakna antara skor OHI‑S dan kadar IL‑1β saliva (r=0,536; p=0,001), yang mengindikasikan bahwa semakin buruk kebersihan mulut, semakin tinggi aktivitas inflamasi gingiva yang tercermin dari peningkatan IL‑1β. Kesimpulan: Kebersihan mulut kategori sedang–buruk pada remaja dengan gingivitis berhubungan signifikan dengan peningkatan kadar IL‑1β saliva. IL‑1β saliva berpotensi sebagai biomarker inflamasi non‑invasif yang dapat dikombinasikan dengan OHI‑S untuk penilaian komprehensif status inflamasi gingiva serta perencanaan strategi pencegahan progresi penyakit periodontal pada populasi remaja.
Rincian Artikel
Terbitan
Bagian

Artikel ini berlisensiCreative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Cara Mengutip
Referensi
. Uzunkaya, M., Özdemir, E., Gündoğar, H., & Kurutas, E. (2024). The effect of periodontal health and disease on interleukin 1β and nesfatin-1 levels in gingival crevicular fluid: A cross-sectional study. Central-European Journal of Immunology, 49, 187 - 193. https://doi.org/10.5114/ceji.2024.140637
. Kredig, C., Peuckert, E., Schmidtmann, I., Drechsler, T., & Erbe, C. (2025). Oral health in adolescents: periodontal inflammatory biomarkers during orthodontic clear aligner therapy. Clinical Oral Investigations, 29. https://doi.org/10.1007/s00784-025-06212-9
. Sumbayak, I., Masulili, S., Tadjoedin, F., Sulijaya, B., Mutiara, A., Khoirowati, D., Soeroso, Y., & Bachtiar, B. (2023). Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis. Geriatrics, 8. https://doi.org/10.3390/geriatrics8040079
. Kadayıf, A., Taşçi, Ö., & Karaduman, B. (2025). Effects of non-surgical periodontal therapy on gingival crevicular fluid CTRP-1, TNF-α, and IL-10 levels. Clinical Oral Investigations, 29. https://doi.org/10.1007/s00784-025-06420-3
. Sağlam, E., Toraman, A., Savran, L., Sağlam, M., & Koseoglu, S. (2025). Meteorin-like levels of oral fluids in periodontal health and diseases: a comparative cross-sectional study. Clinical Oral Investigations, 29. https://doi.org/10.1007/s00784-025-06222-7
. Bolyarova-Konova, T., Petkova, S., Mihaylova, H., Velikova, T., Ivanova-Todorova, E., Tumangelova-Yuzeir, K., & Todorova, D. (2020). Concentrations of Interleukin-1ß in Gingival Crevicular Fluid and Saliva - a Potential Diagnostic Biomarker of Periodontal Diseases.. Folia medica, 62 4, 825-830. https://doi.org/10.3897/folmed.62.e49872
. Alarcón-Sánchez, M., Rodríguez-Montaño, R., Mosaddad, S., & Heboyan, A. (2025). Levels of IL‐1β, MMP‐8, and MMP‐9 in the Saliva of Subjects With Periodontitis: A Systematic Review and Meta‐Analysis. Journal of Clinical Laboratory Analysis, 39. https://doi.org/10.1002/jcla.70040
. Ali, M., Taj, Y., Tanwir, F., Bakhat, S., & Ahmed, S. (2025). MMP-8, IL-6, and IL-1β: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis.. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 35 7, 825-829. https://doi.org/10.29271/jcpsp.2025.07.825
. Blanco-Pintos, T., Regueira-Iglesias, A., Seijo-Porto, I., Balsa‐Castro, C., Castelo-Baz, P., Nibali, L., & Tomás, I. (2023). Accuracy of periodontitis diagnosis obtained using multiple molecular biomarkers in oral fluids: A systematic review and meta-analysis.. Journal of clinical periodontology. https://doi.org/10.1111/jcpe.13854
. Sachelarie, L., Stefanescu, C., Murineanu, R., Grigorian, M., Zaharia, A., Scrobotă, I., & Hurjui, L. (2025). Role of Salivary Biomarkers IL-1β and MMP-8 in Early Detection and Staging of Periodontal Disease. Medicina, 61. https://doi.org/10.3390/medicina61040760
. Abdullameer, M., & Abdulkareem, A. (2023). Salivary interleukin-1β as a biomarker to differentiate between periodontal health, gingivitis, and periodontitis.. Minerva dental and oral science. https://doi.org/10.23736/s2724-6329.23.04778-2
. Teles, F., Martin, L., Patel, M., Hu, W., Bittinger, K., Kallan, M., Chandrasekaran, G., Cucchiara, A., Giannobile, W., Stephens, D., & Kantarcı, A. (2024). Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment. Journal of Clinical Periodontology, 52, 40 - 55. https://doi.org/10.1111/jcpe.14061
. Iddi, S., Dan Donohue, M. C. (2022). Power And Sample Size For Longitudinal Models In R – The Longpower Package And Shiny App. R Journal, 14(1), 264–281. Https://Doi.Org/10.32614/Rj-2022-022
. Islamiati, N., Suryanti, N., & Setiawan, A. (2022). Hubungan penilaian diri dan perilaku kebersihan gigi mulut pada remaja dan ibuThe correlation between dental hygiene behavior and self-assessed oral hygiene of adolescents and mothers in Desa Sumber Jaya Bekasi Regency. Padjadjaran Journal of Dental Researchers and Students. https://doi.org/10.24198/pjdrs.v6i2.33251
. Siregar, R., Nainggolan, S., Saragih, A., & Aritonang, N. (2023). Hubungan Kebersihan Gigi Dan Mulut (OHI-S) Dengan Gingival Indeks Pada Wanita Pubertas Smp Negeri 2 Pancur Batu. Jurnal Ilmiah Pannmed (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist). https://doi.org/10.36911/pannmed.v18i2.1597
. Salim, A., Angelova, S., Roussev, B., Sokrateva, T., Kiselova-Kaneva, Y., Peev, S., & Ivanova, D. (2023). Salivary Interleukin-6, Interleukin-1β, and C-Reactive Protein as a Diagnostic Tool for Plaque-Induced Gingivitis in Children. Applied Sciences. https://doi.org/10.3390/app13085046
. Al-Musawi, M., & Ali, O. (2023). Assessment of Salivary Interleukin-1β Levels in Patients with Gingivitis and Periodontitis: An Analytical Cross-Sectional Study. Dental Hypotheses, 14, 3 - 6. https://doi.org/10.4103/denthyp.denthyp_148_22
. Yavuz, M., Pekbağrıyanık, T., Sağlam, M., & Köseoğlu, S. (2019). Evaluation of milk fat globule-epidermal growth factor–factor VIII and IL-1β levels in gingival crevicular fluid and saliva in periodontal disease and health. Odontology, 107, 449 - 456. https://doi.org/10.1007/s10266-019-00419-5
. Sumendap, I., Sutadi, H., Fauziah, E., & Wahidiyat, P. (2025). Effect of Lactobacillus reuteri probiotic on gingival index and Interleukin-1β levels of children with thalassemia experiencing gingivitis.. Journal of the Indian Society of Pedodontics and Preventive Dentistry, 43 2, 231-235. https://doi.org/10.4103/jisppd.jisppd_146_25
. Relvas, M., Mendes-Frias, A., Gonçalves, M., Salazar, F., López-Jarana, P., Silvestre, R., & Da Costa, A. (2024). Salivary IL-1β, IL-6, and IL-10 Are Key Biomarkers of Periodontitis Severity. International Journal of Molecular Sciences, 25. https://doi.org/10.3390/ijms25158401
. Abdul-Wahab, H., Salah, R., & Abdulbaqi, H. (2024). Salivary levels of catalase, total antioxidant capacity and interleukin-1β and oral health-related quality of life after matcha and green tea consumption for patients with gingivitis: A randomized clinical trial.. International journal of dental hygiene. https://doi.org/10.1111/idh.12820
. Gomes, A., Douglas-De-Oliveira, D., Ferreira, S., Silva, T., Cota, L., & Costa, F. (2019). Periodontal disease, peri-implant disease and levels of salivary biomarkers IL-1β, IL-10, RANK, OPG, MMP-2, TGF-β and TNF-α: follow-up over 5 years. Journal of Applied Oral Science, 27. https://doi.org/10.1590/1678-7757-2018-0316
. Zakiawati, D., & Sufiawati, I. (2021). Peran biomarker saliva dalam deteksi penyakit mulut menggunakan nanoteknologi sebagai metode yang menjanjikanRole of salivary biomarkers in the detection of oral diseases using nanotechnology as a promising method. **, 5, 7. https://doi.org/10.24198/pjdrs.v5i1.25998
. Winengsih, E., & Sari, D. (2025). Hubungan Oral Hygiene dengan Kejadian Gingivitis Pada Ibu hamil TM II di Kota Bandung. Bandung Conference Series: Medical Science. https://doi.org/10.29313/bcsms.v5i2.20977





