Hubungan Kadar Matrix Metalloproteinase-8 (MMP-8) pada Pasien Gingivitis Setelah Tindakan Scaling dan Root Planing Berdasarkan Gingival Index (GI)
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Thifla Rafifa Wirza, Nita Afriani, Nila Kasuma (2026). Hubungan Kadar Matrix Metalloproteinase-8 (MMP-8) pada Pasien Gingivitis Setelah Tindakan Scaling dan Root Planing Berdasarkan Gingival Index (GI). Journal of Pharmaceutical and Sciences, JPS Volume 9 Nomor 1 (2026). https://doi.org/10.36490/journal-jps.com.v9i1.1419
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Penelitian ini bertujuan untuk menganalisis hubungan Gingival Index (GI) terhadap kadar Matriks Metaloproteinase-8 (MMP-8) pada saliva pasien gingivitis pasca Scaling Root Planing (SRP). Sebanyak 36 pasien gingivitis berusia 15-24 tahun yang menjalani SRP di Kota Padang menjadi sampel penelitian. Pemeriksaan GI dilakukan dengan menggunakan probe WHO, dan pengambilan sampel saliva dilakukan pada hari ke-7 pasca SRP menggunakan metode unstimulated saliva. Kadar MMP-8 dalam saliva dianalisis menggunakan ELISA kit Hasil penelitian menunjukkan rerata kadar MMP-8 yang lebih tinggi pada kelompok gingivitis sedang dan berat dibandingkan kelompok ringan, namun variasi antar individu sangat besar. Uji Kruskal-Wallis menunjukkan bahwa perbedaan kadar MMP-8 antar kategori GI tidak signifikan secara statistik (p = 0,584). Meskipun ada tren peningkatan, hasil ini menunjukkan bahwa MMP-8 tidak dapat digunakan sebagai penentu tunggal derajat keparahan gingivitis, dan lebih tepat digunakan sebagai biomarker pendukung yang dikombinasikan dengan parameter klinis lainnya.
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