Use of Combination Therapy in Malaria Treatment and Prevention in Indonesia
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Keywords

treatment, malaria, combination therapy, parasitic disease

How to Cite

Trasia, R. F. (2021). Use of Combination Therapy in Malaria Treatment and Prevention in Indonesia. Journal of Pharmaceutical And Sciences, 4(1), 29-33. https://doi.org/10.36490/journal-jps.com.v4i1.61
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Abstract

Malaria is still a health problem in Indonesia. Treatment of malaria often encounters obstacles. Resistance to various malaria drugs in some areas causes an increase in morbidity and mortality due to malaria. Rational use of malaria drugs that are still effective and available is important. Therefore, this article will review the use of combination therapy in the treatment of malaria in Indonesia. The purpose of using combination therapy is to increase the efficacy of treatment and slow down the occurrence of resistance to each component in the drug. From this article, it can be concluded that artemisinin-based combinations using artemisinin derivatives are still effective for use as combination therapy against malaria. This combination can be a fixed combination or co-administered. The drugs that can be combined are 4-aminoquinoline, antifolate, 4-quinoline-methanol, artemisinin and its derivatives, antibiotics, and atovaquone-proguanil. It is hoped that the combination of these drugs can still be used for a long period of time, remain safe, effective and affordable by the community.

https://doi.org/10.36490/journal-jps.com.v4i1.61
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References

Ahmadi, Fahmi U. (2019) Combating HIV/AIDS, Malaria and other diseases.

Beales PF. (2009) The epidemiology of malaria. In: Gilles HM. Protozoal diseases. New York: Oxford University Press. P.121-69

Dasopang, E. S., Hasanah, F., Fauziah, I., Salman, S., & Bakri, T. K. (2020). Potential side effects of medicine on patients with tuberculosis fixed-dose combination in dr. Pirngadi Hospital, Medan. Jurnal Natural, 20(1), 10-14.

White NJ. (2010) Antimalarial drug resistance. J Clin Invest; 113: 1084-92.

Nomura T, Carlton JMR, Baird JK, Portillo HA, Fryauff DJ, Rathore D et al. (2011) Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria. J Infect Dis; 183:1653-61.

Saleha, S.; Salman; Saiful. (2013). Preparation and characterization edible film packaging from carrageenan. In Proceedings of The Annual International Conference, Syiah Kuala University-Life Sciences & Engineering Chapter (Vol. 3, No. 3).

Sulaiman, T. N. S., & Sulaiman, S. (2020). Eksipien Untuk Pembuatan Tablet Dengan Metode Kempa Langsung. Journal of Pharmaceutical and Sciences, 3(2), 64-76.

Suardi, M., Wangi, Q. A., Salman, Zaini, E., & Akmal, D. (2016). Microencapsulation of verapamil hydrochloride using poly (3-hidroxybutyrate) as coating materials by solvent evaporation method. Research Journal of Pharmaceutical Biological and Chemical Sciences, 7(1), 1725-1732.

Syafrudin D, Asih PBS, Casey GJ, Maguire J, Baird JK, Nagesha HS, et al. (2012) Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia. Am J Trop Med Hyg; 72:174-81

WHO Geneva. (2013) Assessment and monitoring of antimalarial drug efficacy for the treatment of uncomplicated falciparum malaria; 50.

Murphy GS, Basri H, Purnomo, Anderson EF, Bangs MJ, Mount DL. (2014) Vivax malaria resistant to treatment and prophylaxis with chloroquine. Lancet; 341: 96-100

Olliaro P, Nevii C, Lebras J, Ringwald P, Mussano P, Gamer P, et al. (2015) Systematic review of amodiaquine treatment in uncomplicated malaria. 348: 1196-201.

Staedke SG, Kamya MR, Dorsey G, Gasasira A, Ndeezi G, Charlebols ED, et al. (2016) Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for the treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomized trial. 358: 368-74.

Basco LK, Same-Ekobo A, Ngane VF, Ndounga M, Metoh T, Ringwald P. Soula G. (2017) Therapeutic efficacy of sulfadoxine-pyrimethamine, amodiaquine and the combination against uncomplicated Plasmodium falciparum malaria in young children in Cameroon; 80: 538-45.

Darlow B, Vrbova H, Gibney S, Joelly D, Stace J, Alpers M. (2018) Sulfadoxine-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. Am J Trop Med Hyg; 31: 1-9.

Baird JK, Basri H, Jones TR, Purnomo, Bangs MJ, Ritonga A. (2009) Resistance to antimalarials by Plasmodium falciparum in Arso Pir, Irian Jaya, Indonesia. Am J Trop Med Hy; 44:640-44.

Fryauff DJ, Leksana B, Masbar S, Wiady I, Sismadi P, Susanti AI, et al. (2010). The drug sensitivity and transmission dynamics of human malaria on Nias Island., North Sumatra, Indonesia. Ann Trop Med Parasitol; 96:447-62

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