Inflammation is a local reaction of an organism to an irritant or non-physiological state. Existing anti-inflammatory treatments have many side effects if used for a long time. Indonesian people have known and made bay leaves as anti-inflammatory drugs. The purpose of this study was to determine the antiinflammatory activity of bay leaf water extract (Sygyzium polyanthum Wight.) On the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The data obtained were analyzed by SPSS 20.0 ANOVA method at a confidence level of 95%. The results of the characteristics of the bay leaf simplicia showed that the water content was 6.6%, the water soluble extract content was 35%, the soluble extract content of ethanol was 21%. The antiinflammatory test results, observed by the percentage of inflammation in the induction group, had the highest percentage of inflammation compared to the other test groups at minute (T300). Whereas in the percentage of inflammation inhibition, all groups of test extracts have effectiveness that is comparable to the comparison group at (T300). EADS group 50 mg / kgbb is the best dose of extract as anti-inflammatory at (T300) where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals.
Aspan, R. (2008). Taksonomi Koleksi Tanaman Obat Kebun Tanaman Obat Citeureup. Jakarta: Badan Pengawas Obat dan Makanan Republik Indonesia. Hal. 39.
Dalimartha, S. (2000). Atlas Tumbuhan Obat Indonesia Edisi II. Jakarta: Merentas Generasi Sehat .
Depkes RI. (1995). Materia Medika Indonesia Jilid VI. Jakarta: Direktorat Jendral Pengawas Obat Dan Makanan.
Depkes RI. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat Edisi I. Jakarta: Departemen Kesehatan RI. Hal. 3, 5,10 - 12.
Depkes RI. (2010). Farmakope Indonesia Edisi IV. Jakarta: Departemen Kesehatan Republik Indonesia.
Divison, H. P. (1996). Goodman & Gilman's The Pharmacological Basis Of Theraupetics Edisi 9. USA: McGraw-Hill.
Dyke, K. A. (2003). Antiinflammatory And Antirheumatic Drugs. Dalam Modern Pharmacology With Clinical Application. West vVrginia: Department of Pharmacology and Toxicology, West Virginia University Robert C. Hal. 424-425
Handa, S. S. (2008). An Overview of Extraction Techniques for Medicinal and Aromatic Plants. Dalam Extraction Technologies for Medicinal and Aromatic Plants. Trieste: International Centre For Science And High Technology. Hal. 21-25.
Harborne, J. (1987). Metode Fitokimia : Penuntun Cara Menganalisis Tumbuhan. Bandung: ITB.
Hartanto, H. (1995). Obat-Obat Anti-inflamasi Dan Autakoid. Dalam Farmakologi Ulasan Bergambar Edisi II. Jakarta: Widya Medika. Hal. 405, 406.
Katzung. (2002). Farmakologi Dasar dan Klinik Edisi II. Jakarta: Salemba Medika. Hal. 449-454, 462.
Ramadhani, R. S. A. (2000). Aktivitas Antiinflamasi Berbagai Tanaman Diduga Berasal Dari Flavonoid. Jurnal Farmasi Universitas Padjadjaran, 4(4), 1-12.
Sumono, A & Wulan, A. (2008). The Use Of Bay Leaf (Eugenia polyantha Wight.). Jurnal Kedokteran Gigi Universitas Jember, 41(3), 147-150.
Patel, M. (2012). In Vivo Animal Models in Preclinical Evaluation of Anti-Inflamatory Activity- A Review. International Journal of Pharmaceutical Research & Allied Sciences PES College of Pharmacy India, 1(2), 1-4.
Raymond, C.R. P. J. (2009). Handbook Of Pharmaceutical Excipients Edisi VI. London Chicago: RPS Publisihing. Hal. 122-125.
WHO. (1999). WHO Monographs On Selected Medicinal Plants Volume 1 Geneva: WHO Library. Hal. 1.
Wilmana, P. F. (1995). Analgesik Antiinflamasi Non Steroid Dan Obat Pirai. Dalam Farmakologi Dan Therapy Edisi 4. Jakarta: Universitas Indonesia. Hal. 207.
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