SEDATIVE EFFECT TEST OF ETHANOL EXTRACT OF RAMBUSA (Passiflora foetida L.) LEAVES TO MALE MICE (Mus musculus)
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Keywords

Diazepam
mice
Rambusa leaves
sedatives

How to Cite

saputri, muharni, Sudewi, S., Karimah, N., & Nadia, S. (2021). SEDATIVE EFFECT TEST OF ETHANOL EXTRACT OF RAMBUSA (Passiflora foetida L.) LEAVES TO MALE MICE (Mus musculus). Journal of Pharmaceutical And Sciences, 4(2), 93-100. https://doi.org/10.36490/journal-jps.com.v4i2.80
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Abstract

A common sleep disorder is insomnia, which occurs when a person has difficulty sleeping. One way to deal with insomnia is by giving sedative-hypnotic drugs. One of the plants used as ingredients in traditional medicine is the Rambusa (Passiflora foetida L.) plant. The ethanol extract of rambusa leaves contains alkaloid compounds, saponins, tannins, and steroids. These compounds can provide a sedative effect. This research was conducted to determine the sedative effect of rambusa leaf extract (Passiflora foetida L.) on mice (Mus musculus). This research is an experimental study with a maceration extraction method using 30 mice and divided into 5 groups. Group I (negative control) CMC 0.5%, group II (positive control) Diazepam, groups III, IV, V (treatment) of ethanol extract of rambusa leaves with a dose of 0.16 g / kgBB, 0.34 g / kgBB, 0, 68 g / kgBB. Giving to mice orally and observing body turning reflex, turning time and falling time using the Traction Test. The sedative effect test for each group was statistically analyzed using the SPSS 18.0 Post-Hoc Duncan test method. The results of the One Way ANOVA statistical test showed a significant difference between the treatment groups and the value P=0.000 (P<0.05). In Duncan's Post-Hoc test, doses II and III were not significantly different from diazepam. Doses II and III had the same sedative effect as diazepam. So it can be concluded that the ethanol extract of Rambusa leaves has a sedative effect.

 

https://doi.org/10.36490/journal-jps.com.v4i2.80
pdf (Bahasa Indonesia)

References

Afriani, S.R., Riyanto., dan Madang, K. 2016. Pengaruh Ekstrak Daun Sirih (Piper Bettle L.) Terhadap Efek Sedasi Mencit (Mus Musculus L.) dan Sumbangannya Pada Pembelajaran Biologi SMA. Jurnal Pembelajaran Biologi Universitas Sriwijaya. 3(1): 32-34.

Amalia, R. 2009. Pengaruh Ekstrak Pegagan (Centella asiatica (L.) Urban) Terhadap Efek Sedasi pada Mencit BALB/C. Karya Tulis Ilmiah. Semarang: Fakultas Kedokteran Universitas Diponegoro. Halaman: 10.

Astuti, M.D., Sriwinarti, T dan Mustikasari, K. 2017. Isolasi Dan Identifikasi Senyawa Terpenoid Dari Ekstrak N-Heksana Daun Kelopak Tambahan Tumbuhan Permot (Passiflora foetida L). Sains dan Terapan Kimia Universitas Lambung Mangkurat. 11(2): 80-89.

Dewatisari, W. F., Rumiyanti, L., dan Rachmawati, I. 2017. Rendemen dan Skrinning Fitokimia pada Ekstrak Daun Sanseviera sp. Jurnal Penelitian Pertanian Terapan.17(3): 197.

Herwin., Kosman, R., dan Siami, I. 2013. Produksi Sediaan Kombucha dari Daun Permot (Passiflora foetida L) secara fermentasi. Jurnal AS-Syifaa Fakultas Farmasi Universitas Muslim Indonesia. 05(01): 20-27.

Mulyani, E. 2019. Studi In-Vitro : Efek Anti Kolesterol Ekstrak Daun Rambusa (Passiflora foetida L). Jurnal Surya Medika Program Studi D-III Farmasi Fakultas Ilmu Kesehatan Universitas Muhammadiyah Palangkaraya. 4(2): 60-65.

Ningsih, S dan Rahma, N. 2014. Kemampuan Efek Sedasi Infusa Umbi Rumput Teki (Cyperus rotundus L.) Pada Mencit Jantan Ras Swiss. Indonesian Journal On Medical Science. 1(2): 68.

Novindriani, D., Wijianto, B., dan Andrie, M. 2013. Uji Efek Sedatif Infusa Daun Kratom (Mitragyna speciosa) Pada Mencit Jantan Galur BALB/c. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN. 3(1): 64

Rahmah, A.R. 2016. Uji Efek Sedatif Ekstrak Daun Gynura Procumbens (LOUR.) Merr dengan Ekstraksi Bertingkat terhadap Mencit Jantan Galur Balb/c. Skripsi. Surabaya: Fakultas Farmasi Universitas Airlangga. Halaman: 12-15.

Ridayani, Y. 2013. Uji Efek Sedatif Fraksi Etanol Daun Kratom (Mitragyna Speciosa Korth.) Pada Mencit Jantan Galur Balb/C. Skripsi. Pontianak: Fakultas Kedokteran Universitas Tanjungpura. Halaman: 6.

Zainab, S. 2016. Penetapan Parameter Standarisasi Non Spesifik dan Spesifik Ekstrak Daun Pacar Kuku. Jurnal Penetapan Parameter Standarisasi. 13(2): 212-226.

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