Bitter melon leaves contain secondary metabolites such as flavonoids, tannins, saponins, steroids, alkaloids, and terpenoids which can inhibit bacterial growth. Bitter melon leaves can be used as a medicine, one of which is to treat wounds because they have bacterial inhibition and can cover wounds. This study aims to determine the effect of the basis on the stability of ointment and to find out which formulations meet the stability requirements of ointment. This type of research is experimental. The base of the ointment used is the base of the hydrocarbon ointment and the base of the absorbent ointment. The extract of pare leaf extract was carried out by maceration using 70% ethanol. The pare ethanol extract ointment was made in 3 formulas using the same base and different concentrations of the extract. Preparation of ointments using the smelting method. Evaluation of ointment was carried out by organoleptic test, homogeneity test, pH measurement test, and dispersion test. The test results of all ointment preparations from the formula I, formula II and formula III met the organoleptic test quality parameters, homogeneity and pH test. For the spread test on each formula, the only formula I approach the physical stability test parameter.
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