UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans SERTA FORMULASI SEDIAAN PASTA GIGI EKSTRAK ETANOL BUAH OKRA HIJAU (Abelmoschus esculentus) DAN TULANG IKAN TUNA (Thunnini)
Vol 5 No 2 (2022), Articles
Vol 5 No 2 (2022)

UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans SERTA FORMULASI SEDIAAN PASTA GIGI EKSTRAK ETANOL BUAH OKRA HIJAU (Abelmoschus esculentus) DAN TULANG IKAN TUNA (Thunnini)

Articles
https://doi.org/10.36490/journal-jps.com.v5i2.148
Published November 28, 2022
Muhammad Andry
Institut Kesehatan Helvetia
Hanafis Satra Winata
Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia Medan, Indonesia
pdf (Bahasa Indonesia)

Keywords

Toothpaste
Green lady finger (Abelmoschus esculentus)
Tuna (Thunnus albacares)
Antibacterial

How to Cite

Andry, M., & Winata, H. (2022). UJI AKTIVITAS ANTIBAKTERI Streptococcus mutans SERTA FORMULASI SEDIAAN PASTA GIGI EKSTRAK ETANOL BUAH OKRA HIJAU (Abelmoschus esculentus) DAN TULANG IKAN TUNA (Thunnini). Journal of Pharmaceutical And Sciences, 5(2), 250-258. https://doi.org/10.36490/journal-jps.com.v5i2.148
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Abstract

Background: Green lady finger contains secondary metabolites such as flavonoids that have antibacterial properties. Fish bones contain 60-70%minerals with hydroxyapatite, carbonated apatite or dalhite. Fish bones provide calcium (Ca) and are abrasive in the toothpaste dosage form. Purpose: This study aimed to make toothpaste dosage forms containing ethanolic extracts of green lady finger (Abelmoschus esculentus) and tuna fish bones (Thunnus albacares) to test antibacterials against Streptococcus mutans. Methods: This study technique was implemented experimentally, including the formulation of the toothpaste dosage form with concentrations of ethanol extract of green lady finger fruit 20%, 15%, 10%, positive control and negative control physical quality inspection including organoleptic examination, foaming power, extrudability, homogeneity, pH and viscosity as well as testing antibacterial activity exhibited by Streptococcus mutans. Results: The results demonstrated that the ethanolic extract of green lady finger and tuna fish bones could form into a toothpaste dosage form with a homogenous composition and a pH that was suitable for oral use (7,8-8,4), stable in storage, had a viscosity value of 315-485, very easy to remove in the tube, spreadability (6,4-6,7 cm), produces foam height between (7,4-7,7 cm) and has antibacterial activity by Streptococcus mutans. Conclusion: This study concludes that the ethanolic extract of green lady finger and tuna fish bones has antibacterial action against Streptococcus mutans and can be made into toothpaste.

https://doi.org/10.36490/journal-jps.com.v5i2.148
pdf (Bahasa Indonesia)

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