Evaluation of Anti-acne Gel Preparations Combination of Aloe Vera Leaf Extract (Aloe vera (L) Brum F.) And Betel Leaf Extract (Piper betle L.)
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Keywords

gel
anti-acne
extract
aloe vera
betel

How to Cite

Ginting, O., & Rahmah, P. (2022). Evaluation of Anti-acne Gel Preparations Combination of Aloe Vera Leaf Extract (Aloe vera (L) Brum F.) And Betel Leaf Extract (Piper betle L.). Journal of Pharmaceutical And Sciences, 5(1), 12-20. https://doi.org/10.36490/journal-jps.com.v5i1.73
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Abstract

The use of natural ingredients as herbal medicines has been widely carried out by the community today. Besides being able to save costs, if it can be made easily and cheaply and people believe it has fewer side effects and savety. Aloe vera (Aloe vera (L) Burm.F.) and betel leaf (Piper betle L.) are popular and easy to obtain plants. This plant contains secondary metabolites in the form of flavonoids, tannins, saponins and alkaloids. Secondary metabolite compounds contained in aloe vera and betel leaf can help the occurrence of infections by various skin bacteria that cause itching and acne. To overcome one of the main problems of facial skin, namely acne, the most suitable and effective dosage form to use is gel preparation. In this study, a gel formulation was carried out with 5 formulas. Which is based on differences in the concentration of the active substance of aloe vera extract and betel leaf extract. This research was conducted experimentally and aims to determine the effect of variations in the concentration of the active substance on the physical and chemical stability of the preparation. The extraction process was carried out by maceration using 80% ethanol. The evaluations carried out included: organoleptic tests, pH tests, homogeneity tests and tests for the spreadability of gel preparations for 21 days. The results showed that the best formula was formula 2. This proves that changes in temperature and storage duration can affect the quality of the gel so that it can affect the physical and chemical properties of the gel produced.

https://doi.org/10.36490/journal-jps.com.v5i1.73
pdf (Bahasa Indonesia)

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