The use of natural ingredients as herbal medicines has been widely carried out by the community today. Besides being able to save costs, if it can be made easily and cheaply and people believe it has fewer side effects and savety. Aloe vera (Aloe vera (L) Burm.F.) and betel leaf (Piper betle L.) are popular and easy to obtain plants. This plant contains secondary metabolites in the form of flavonoids, tannins, saponins and alkaloids. Secondary metabolite compounds contained in aloe vera and betel leaf can help the occurrence of infections by various skin bacteria that cause itching and acne. To overcome one of the main problems of facial skin, namely acne, the most suitable and effective dosage form to use is gel preparation. In this study, a gel formulation was carried out with 5 formulas. Which is based on differences in the concentration of the active substance of aloe vera extract and betel leaf extract. This research was conducted experimentally and aims to determine the effect of variations in the concentration of the active substance on the physical and chemical stability of the preparation. The extraction process was carried out by maceration using 80% ethanol. The evaluations carried out included: organoleptic tests, pH tests, homogeneity tests and tests for the spreadability of gel preparations for 21 days. The results showed that the best formula was formula 2. This proves that changes in temperature and storage duration can affect the quality of the gel so that it can affect the physical and chemical properties of the gel produced.
Damayanti, 2005; dalam Hapsari, Putri P., Nanik S., Akhmad M., 2017. Formulasi Permen Jelly Ekstrak Daun Sirih (Piper betle L.) – Daun Suji (Pleomele angustofolia). JITIPARI (Jurnal Ilmiah Teknologi Dan Industri Pangan UNISRI), 2(1).
Dehari, P., 2006; dalam Arwinda, G., Njoo M., P.S., Aylinawati, Nani,I. 2013. Pembuatan Sabun Dengan Lidah Buaya (Aloe vera) Sebagai Antiseptik Alami. Jurnal Ilmiah Widya Teknik. Vol. 12 (1).
DepKes RI. 1995. Farmakope Indonesia, Edisi IV. Jakarta: Departemen Kesehatan RI.
DepKes RI. 2000. Farmakope Herbal Indonesia. Edisi IV. Jakarta: Depkes RI.
Ginting, O, S., 2017. Perbandingan Aktivitas Antibakteri Ekstrak Etanol Biji Pepaya (Carica papaya L.) Dari Dua Varietas Terhadap Bakteri Escherichia coli. Jurnal STIKNA Vol 01, No. 02.
Ginting, O, S., 2021. Perbandingan Aktivitas Antibakteri Ekstrak Etanol Biji Pepaya (Carica papaya L.) Terhadap Bakteri Escherichia coli Dan Staphylococcus aureus. Forte Journal, Vol. 01, No. 01.
Hasyim, N., Pare, K.L., Junaid, I., dan Kurniati, A. 2012. Formulasi dan Uji Efektivitas Gel Luka Bakar Ekstrak Daun Cocor Bebek (Kalanchoe pinnata L.) pada Kelinci (Oryctolagus cuniculus). Majalah Farmasi dan Farmakologi.
Istiana, S., 2016. Formulasi Sediaan Gel Basis Na-Cmc Ekstrak Etanol Daun Cocor Bebek (Kalanchoe pinnata (Lmk.) Pers.) Sebagai Penyembuh Luka Bakar Pada Kelinci. Surakarta. Universitas Muhammadiyah Surakarta.
Maswadeh, H., Semreen, M., and Naddaf, A. 2006. Anti-inflammatory Activity of Achillea and Ruscus Topical Gel On Carragenan-induced Paw Edema in Rats. Acth Poloniae Pharmaceutica-Drug Research.
Putra. IGN.A.P., & Setyawan. E.I. (2015). Pengembangan Basis Cold Cream Ekstrak Kulit Buah Manggis (Garcinia Mangostana L.) Yang Memenuhi Sifat Farmasetis. Media Farmasi, Vol. 11 No.2 :133-142
Rowe, R.C., Paul JS, Marian EQ. 2009. Handbook Of Pharmaceutical Excipients Sixth Edition. USA: The Pharmaceutical Press.
Rufiati, E. 2011. Pengaruh Suhu Terhadap Laju Reaksi. Universitas Airlangga.
Sahara, A., 2015. “Efektivitas Gel Campuran Daun Jambu Biji (Psidium guajava) Dan Lidah Buaya (Aloe vera) Untuk Mengurangi Radang Jerawat Pada Kulit Wajah”. Pendidikan Kesejahteraan Keluarga. Fakultas Teknik. Universitas Negeri Semarang.
Supomo, Sukawaty, Y., Baysar, F, 2015. Formulasi gel hand sanitizer dari kitosan dengan basis natrium karboksimetil selulosa. Akademi farmasi samarinda. Hal 31-37.
Tambunan, M.L., Sitompul, E dan Ginting, O,S., 2018. Perbandingan Aktivitas Antibakteri Ekstrak Etanol Dan Ekstrak n-Heksana Biji Pepaya (Carica papaya L.) Terhadap Bakteri Escherichia coli. Jurnal STIKNA Vol. 02, No. 01.
Tranggono, R.I dan Latifah, F. 2007. Buku Pegangan Ilmu Pengetahuan Kosmetik. Jakarta: PT.Gramedia Pustaka Utama. Hal 11-13.
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