Pain is a feeling of discomfort caused by intense or destructive stimuli, which, if left untreated, can affect your daily routine. Pain can be treated with analgesics. One of the plants that are thought to have analgesic effects is the leaves of the mahkota dewa. The purpose of this study was to determine the analgesic effect and dosage of the ethanol extract of mahkota dewa leaves and to determine the effectiveness of the ethanol extract of the mahkota dewa leaves as an analgesic using the stretching method.
The study began with the collection and processing of the leaves of the mahkota dewa into ethanol extract using the maceration method; then, the research was continued within in vivo analgesic activity testing of 25 mice that had been induced by pain using 1% acetic acid. The induced mice were divided into five treatment groups, where the mice in the first group served as a negative control group; in this group, they were given CMC at a dose of 0.5%. The second group of mice, which were positive controls, were given mefenamic acid at a dose of 500 mg. In contrast, in mice, the third, fourth, and fifth groups, which were the treatment group, were given ethanol extract of the leaves of mahkota dewa with consecutive doses of 0.25 g/kg BW, 0.50 g/kg BW, 0.75 g/kg BW. Parameters measuring the effectiveness of the extracts used in this study included the amount of stretching, the percentage of analgesic power, and analgesic effectiveness.
The results showed that the positive control group had the highest percentage of analgesic power at 59.9%. At EEDMD 0.75 g/kg BW gained 55.5%. EEDMD at a dose of 0.25 g/kg BW obtained 46.33%. Furthermore, EEDMD at a dose of 0.50 g/kg BW amounted to 55.06%. Furthermore, the percent effectiveness showed that EEDMD 0.75 g/kg BW had the highest percentage effectiveness, namely 92.65%. Whereas at EEDMD 0.25 g/kg BW is 77.29% and in EEDMD 0.50 g/kg BW is 91.91%. Based on the results of statistical analysis using ANOVA, it was found that the ethanol extract of the leaves of the mahkota dewa dosage of 0.75 g / kg BW had analgesic activity close to 500 mg of mefenamic acid.
Akbar, R. H. (2010). Isolasi dan Identifikasi Golongan Flavanoid Daun Dandang Gendis (Clinacanthus nutans) Berpotensi sebagai Antioksidan. Skripsi. Institus Pertanian Bogor. Halaman 3-4.
Barus, N. S. B., Sony, S., Salman, S., Mahmudi, M., & Sunartaty, R. (2018). Uji Toksisitas Subakut Ekstrak Daun Tembakau (Nicotiana Tabacum L.) Yang Difermentasi Terhadap Gambaran Histologi Organ Vital Mencit (Mus Musculus). Jurnal Stikna, 2(2).
Christien, H. (2014). Efektivitas Ekstrak Daun Mahkota Dewa (Phaleria macrocarpa) sebagai Antibakteri untuk Mencegah Serangan Bakteri Aeromonas hydrophila pada Ikan Gurami (Osphronemus gouramy). Skripsi. Fakultas Farmasi. Universitas Sumatra Utara.
Depkes RI. (1995). Farmakope Indonesia. Edisi IV. Jakarta: Departemen Kesehatan RI. Halaman: 50.
Farnswoth, N. R. (1996). Biological and Phytochemical Screening of Plants. Journal of Pharmaceutical Science. 55(3):264
Hanif, M. Q., Yuandani., Harahap, U. (2020). Evaluation of toxic Effect of Phaleria macrocarpa (Scheff.) Boerl Leaf Extract on Hematological Parameters. Asian Journal of Pharmaceutical Research and Development. 8(3): 01-04.
Harbone, J. B. (1987). Metode Fitokimia: Penentuan Cara Modern Menganalisis Tumbuhan. Terjemahan: Kokasih Padmawinanto dan Iwang Suediro. Edisi ke-2. Bandung : Penerbit ITB. Halaman 4-7,147-148.
Harmanto, N. (2001). Mahkota Dewa Obat Pusaka Para Dewa. Jakarta: Agro media pustaka.
Hasan, M. Y., Mahamud, R. A., Rahman, S.,Ahmad, I., Rahmatullah, M. A. (2015). Preliminary Report on Antihyperglicemic and Analgesic Properties of Methanol Extract of Brassica oleraceae L. var. Italica Sprouts. World Journal of Pharmacy and Pharmaceutical Sciences. Vol 4, Issue 09: 225-234
Lestari, I. C. (2018). Efek Antidiabetik Ekstrak Etanol Daun Mahkota Dewa (Phaleria macrocarpa) pada Tikus Diabetes Yang Diinduksi Streptozotosin. Journal of the Medical Sciences. 50(2) 140-149.
Merskey and Bogduk, N. (1994). Classification of Chronic Pain, Second Edition, IASP Task Force on Taxonomy. Seattle: IASP Press.
Mutschler, E. (1991). Dinamika Obat Farmakologi dan Toksikologi Edisi Kelima. Bandung: Institut Tekonolgi Bandung.
Ripa, F. A., Dash, P. R., and Faruk, M. O. (2015). CNS Depressant, Analgesic And Anti-Inflammatory Activities Of Methanolic Seed Extract Of Calamus rotang Linn. Fruits In Rat. Journal Of Pharmacognosy And Phytochemistry. 3(5): 121-125
Tatiya, A. U., Saluja, A. K., Kalaskar, M. G., Surana, S.J. & Patil, P. H. (2017). Evaluation of Analgesic and Anti-inflammatory Activity of Bridelia retusa (Spreng) Bark. Journal of International and Complementary Medicine, 30(1-11).
Sasongko, H., Sugiyarto., Yeni, F., Nur, R. E., Diah, P., Ahmad, D. S., dan Tertri, W. (2016). Analgesic Activity of Ethanolic Extracts of Kaarika Leaves (Carica pubescens) Secara In Vivo. Journal of Pharmaceutical Science and Clinical Research. 01. 83-89.
Wahab, M. F., Yustika. I., Nurdiana., Andi, M. M., dan Putri, B. A. N. (2020). Uji Aktivitas Antimikroba Ekstrak Daun Mahkota Dewa (Phaleria macrocarpa) dengan Metode Difusi Cakram. Indonesian Journal of Fundamental Sciences. 6(1). Halaman 9.
Wahyuningsih, M. S. H., Mubarika, S., Artama, W. T., Wahyuono, S., Ganjar, I. G., (2005). Sitotoksisitas Phalerin Hasil Isolasi dari Daun Mahkota Dewa (phaleria macrocarpa (Scheff.) Boerl) terhadap Berbagai Sel Kanker Manusia In Vitro. Majalah Obat Tradisional 10(32):11-15
Zainab, S. (2016). Penetapan Parameter Standarisasi Non Spesifik dan Spesifik Ekstrak Daun Pacar Kuku. Jurnal Penetapan Parameter Standarisasi. 13(2): 212-226.
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