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direct compression

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Sulaiman, T., & Sulaiman, S. (2020). REVIEW: EXCIPIENTS FOR TABLET MANUFACTURING WITH DIRECT COMPRESSION METHOD. Journal of Pharmaceutical And Sciences, 3(2), 64-76.
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Tablets are very popular in a pharmaceutical dosage form. Tablet preparations can be made in various ways, including by direct compression methods, wet granulation, dry granulation, fast melt granulation, and foam granulation. Each of these methods has advantages and disadvantages. The direct compression methods have the advantages of a fast process that only requires mixing and compressing. Not all active ingredients can be directly compressed because they have a weakness in the flow properties and less compressible. The direct compression process requires additional materials or excipients called filler-binders. This review article will discuss the development of excipients for the manufacture of tablets by direct compression. At present, there are many excipients for direct compression in the market, with various advantages. The excipient is a co-processed material developed from the original material which cannot be used for direct compression excipients. Various co-processing that is done at the end will produce new materials that have better properties. With the availability of various types of direct compression excipients, the formulator has a variety of choices to be applied in the formulas designed. This will provide flexibility in selecting excipients to be applied to various active substances so that they will produce a dosage form with good quality.
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