Anti-Inflamatory Activity and Cyclooxygenase-2 Inhibition of ethanol extract from Malur Leaves (Brucea javanica (L.) Merr)
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Keywords

Brucea javanica
Cyclooxigenase-2
Anti-inflamatory
Edema Volume

How to Cite

Ifora, I. (2020). Anti-Inflamatory Activity and Cyclooxygenase-2 Inhibition of ethanol extract from Malur Leaves (Brucea javanica (L.) Merr). Journal of Pharmaceutical And Sciences, 3(1), 7-13. https://doi.org/10.36490/journal-jps.com.v3i1.33
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Abstract

Inflammation is a normal protective response to tissue damage mediated by Cyclooxigenase-2 (COX-2) enzyme. This study aims to determine the anti-inflammatory activity ethanol extract of (Brucea javanica (L.) Merr.) and its inhibitory effect on COX-2 enzyme. The animals used in this study were male white rats which were divided into 5 groups, dose250 mg/kg BB, dose 500 mg/kg BB, comparative control (Celecoxib), positve control and negative controls. Determining of anti-inflammatory activity was carried out by inducing the soles of the Rats with carragen and then measuring the edema volume using a pletismometer and measuring COX-2 inhibiton using a microplate Reader. The results showed that the ethanol extract of malur leaves doses 250 mg/kg BB and 500 mg/kg BB had significant anti-inflammatory activity (p <0.05). The dose 500 mg/kg BB has a significant inhibitory effect on COX-2 (p <0.05), but dose 250 mg/kg BB does not have significant inhibitory effect on COX-2. It can be concluded that the ethanol extract of malur leaves has anti-inflammatory effects at doses 250 mg/kg BB and 500 mg/kg BB and inhibitory effect against COX-2 at a dose 500 mg/kg BB.

https://doi.org/10.36490/journal-jps.com.v3i1.33
PDF (Bahasa Indonesia)

References

Agrawal, A. D. (2011). Pharmacological activities of flavonoids: a review. International Journal of Pharmaceutical Science Nanotechnology, 4(2): 1394 - 1398.
Angelina, M. M. (2010). Uji aktivitas ekstrak dan fraksinasi daun Brucea javanica (Merril) secara invitro. Indonesian Journal of Applied Chemistry, 12(2): 59-64.
Angelina, M. M., Abdul, M., Hanafi, M. (2011). Ekstrak terstandar secara kimia daun Brucea javanica Merril. Indonesian Journal of Applied Chemistry, 13(2): 45-51.
Anwar, K., Santoso, H. B., & Cahaya, N. (2013). Penghambatan radang infusa daun dadap ayam (Erythrina variegata L.) pada mencit putih jantan yang diinduksi karagenin. Prosiding Semirata FMIPA Universitas Lampung, 45-52.
Ismail, N., Abdullah, H., Jamil, S., Jamalulail, S., Rotondo, D., Seidel, V., (2012). Anticancer and immunomodulating activity of a flavonoid from Brucea javanica leaves. UMT 11th International Annual Symposium on Sustainability Science and Management. 1542-1548.
Katzung, B. G. (2002). Farmakologi dasar dan klinik. (edisi 8). Penerjemah : Bagian Farmakologi Fakultas Kedokteran Universitas Airlangga. Jakarta:Penerbit Salemba Medika.
Kementerian Kesehatan Republik Indonesia. (2011). Suplemen II farmakope herbal Indonesia. (edisi 1). Jakarta: Kementerian Kesehatan Republik Indonesia.
Kim, I. H., Hitotsuyanagi, Y., Takeya, K. (2004). Quassinoid glucosides from seeds of Brucea amarissima. Phytochemistry, 65(23): 3168-3173.
Mycek, M. J., Harvey, R. A., Champe, P. C. (2001). Farmakologi ulasan bergambar (edisi 2). Alih Bahasa Azwar Agoes. Jakarta: Widya Medika.
Nakao, R., Mizukami, C., Kawamura, Y. (2009). Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci, 71(1): 33-41.
Robert, L. J & Morrow, J. D., in Goodman & Gilman. (2008). Dasar farmakologi terapi (edisi 10). Alih Bahasa Tim Bahasa Sekolah Farmasi ITB. Jakarta: Penerbit Buku Kedokteran EGC.
Tjay, T. H., & Rahardja, K. (2007). Obat-obat penting(Edisi 6). Jakarta: Penerbit PT Elex Media Komputindo.
Yang, J., Li, S., Xie, C., Ye, H., Tang, H., Chen, L., Peng, A. (2013). Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea javanica. Journal of Ethnopharmacology, 147(2): 442-446.
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