Formulation of nanoemulsion gel of clove leaf oil (Syzygium Aromaticum L.) Merr. & Perry) and anti-acne activity test

Abstract

Background: The most common skin disease worldwide is acne (acne vulgaris); acne is a chronic inflammatory disease in the pilosebaceous unit. The main factors affecting acne are increased sebum production, keratinocyte secretion, bacterial growth, and inflammation. The objective was to study the physical properties of clove gel (Syzygium aromaticum (L.) Merr. and L.M.). Perry)..Research Objectives: The purpose of this study is to develop nanoemulsion products containing clove oil that have good physical properties and stability.Method: This type of research is experimental and conducted in a medical laboratory. This study evaluated the physical properties of the gel, such as organoleptic evaluation, homogeneity, pH, stickiness, spreadability, and viscosity. In addition, the antibacterial effectiveness test was also carried out, which then determined at what concentration the essential oil could be used as a substitute for antibacterial gels on the market. Results: Results and Discussion The research began with choosing eugenol from clove leaf oil, which acts as an active ingredient in the gel composition. This identification was carried out to ensure that the essential oil used in making the gel in this study contains eugenol, which has been shown to have antibacterial effects in previous studies. Conclusion: Based on the research conducted, it can be concluded that the preparation of Nanoemulsion containing 5% clove oil with 30% Tween 80 as surfactant and 15% PEG 400 as additional surfactant of pharmaceutical requirements, including organoleptic test, homogeneity, pH measurement, viscosity, rheology, lubrication, measure of permeability value, sphere size, PDI value