EVALUATION OF ANTIBIOTICS IN COVID-19 INTENSIVELY HOSPITALIZED PATIENTS WITH PNEUMONIA AT THE H.S SAMSOERI MERTOJOSO HOSPITAL
pdf (Bahasa Indonesia)

Keywords

COVID-19
Pneumonia
Intensive
Antibiotic

How to Cite

Putra, O., Purwiningtyas, M., & Widad, A. (2022). EVALUATION OF ANTIBIOTICS IN COVID-19 INTENSIVELY HOSPITALIZED PATIENTS WITH PNEUMONIA AT THE H.S SAMSOERI MERTOJOSO HOSPITAL. Journal of Pharmaceutical And Sciences, 5(2), 309-320. https://doi.org/10.36490/journal-jps.com.v5i2.146
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Abstract

COVID-19 pneumonia merupakan salah satu komplikasi pada pasien COVID-19 dengan tingkat mortalitas yang tinggi. Pasien COVID-19 dengan pneumonia memerlukan perawatan intensif apabila terjadi kondisi gagal napas atau saturasi oksigen (SpO2) <93%.  Salah satu modalitas pada pasien COVID-19 dengan pneumonia ialah antibiotik. Evaluasi antibiotik diperlukan untuk terwujudnya penggunaan antibiotik yang rasional. Penelitian ini bertujuan untuk mengkaji kesesuaian penggunaan antibiotik pada pasien COVID-19 dengan pneumonia di ruang perawatan intensif Rumah Sakit Bhayangkara H.S Samsoeri Mertojoso Surabaya meliputi kesesuaian rute pemberian, jenis, dosis, frekuensi pemberian, lama pemberian, dan outcome therapy. Penelitian ini merupakan penelitian retrospektif menggunakan rekam medik pasien COVID-19 dengan pneumonia yang dirawat pada bulan Januari – Juli tahun 2021. Didapatkan 58 pasien COVID-19 dengan pneumonia yang memenuhi kriteria inklusi. Levofloksasin, meropenem, dan sefoperason-sulbaktam merupakan antibiotik yang paling banyak diberikan dengan persentase masing-masing 33%, 24%, dan 19%, secara berturut-turut. Keseluruhan antibiotik sudah tepat rute pemberian yang diberikan secara intravena. Berdasarkan kesesuaian jenis antibiotik dan dosis pemberian, diperoleh delapan antibiotik sudah sesuai dan dua antibiotik tidak sesuai berdasarkan frekuensi pemberian. Lama pemberian antibiotik secara umum sudah sesuai dengan pedoman. Ditemukan status pasien yang meninggal dunia lebih banyak selama perawatan dibandingkan dengan yang sembuh Kesimpulan pada penelitian ini adalah antibiotik yang diberikan pada pasien COVID-19 dengan pneumonia yang menjalani perawatan intensif tepat jenis antibiotik, tepat rute pemberian, tepat dosis, dan tepat lama pemberian. Diperlukan upaya yang berkesinambungan antara seluruh tenaga Kesehatan di rumah sakit untuk mewujudkan penggunaan antibiotik yang rasional.

Kata Kunci: COVID-19; Pneumonia; Intensif; Antibiotik

 

https://doi.org/10.36490/journal-jps.com.v5i2.146
pdf (Bahasa Indonesia)

References

): Experience from 350 patients. Infection and Drug Resistance.13: 3907–3918.

Jang SY., Seon JY., Yoon SJ., Park SY., Lee SH., Oh IH. (2021). Comorbidities and factors determining medical expenses and length of stay for admitted covid-19 patients in Korea. Risk Management and Healthcare Policy. 14: 2021–2033.

Juneja D., Savio RD., Srinivasan S., Pandit RA., Ramasubban S., Reddy PK., et al. 2020). Basic critical care for management of COVID-19 patients: Position paper of Indian society of critical care medicine, Part II. Indian Journal of Critical Care Medicine. 24 (Suppl 5): 254–262.

Karampela I & Dalamaga M. (2020). Could Respiratory Fluoroquinolones, Levofloxacin and Moxifloxacin, Prove to be Beneficial as an Adjunct Treatment in COVID-19? Archives of Medical Research. 51(7): 741–742.

Kariyawasam RM., Julien DA., Jelinski DC., Larose SL., Rennert-May E., Conly JM., et al. (2022). Antimicrobial resistance (AMR) in COVID-19 patients: a systematic review and meta-analysis. Antimicrobial Resistance and Infection Control. 11:45

Klutts GN., Squires A., Bowman SM., Bhavaraju A., Kalkwarf KJ. (2022). Increased Lengths of Stay, ICU, and Ventilator Days in Trauma Patients with Asymptomatic COVID-19 Infection. American Surgeon. 88(7):1522–1525.

Kumar A., Jaggi S., Singh S., Dutta K. (2021). Covid-19 pneumonia: An unusual radiological presentation. Indian Journal of Tuberculosis. 68(4):527–528.

Luque S., Benítez-Cano A., Larrañaga L., Sorlí L., Navarrete ME., Campillo N., et al. (2021). Pharmacokinetics and pharmacodynamics of meropenem by extended or continuous infusion in low body weight critically ill patients. Antibiotics.10:666.

Mansab F., Donnelly H., Kussner A., Neil J., Bhatti S., Goyal K. (2021). Oxygen and Mortality in COVID-19 Pneumonia: A Comparative Analysis of Supplemental Oxygen Policies and Health Outcomes Across 26 Countries. Frontiers in Public Health. 9:580585

Ng TM., Ong SWX., Loo AYX., Tan SH., Tay HL., Yap MY., et al. (2022). Antibiotic Therapy in the Treatment of COVID-19 Pneumonia: Who and When? Antibiotics. 11:184

Rees EM., Nightingale ES., Jafari Y., Waterlow NR., Clifford S., Carl CA., et al. (2020). COVID-19 length of hospital stay: A systematic review and data synthesis. BMC Medicine. 18:270

Rousan LA., Elobeid E., Karrar M., Khader Y. (2020). Chest x-ray findings and temporal lung changes in patients with COVID-19 pneumonia. BMC Pulmonary Medicine. 20:245

Rozaliyani A., Savitri AI., Setianingrum F., Shelly TN., Ratnasari V., Kuswindarti R., et al. (2020). Factors Associated with Death in COVID-19 Patients in Jakarta, Indonesia: An Epidemiological Study. Acta Med Indones-Indones J Intern Med. 52(3):246-254

Sieswerda E., de Boer MG., Bonten MMJ., Boersma WG., Jonkers RE., Aleva RM., et al. (2021). Recommendations for antibacterial therapy in adults with COVID-19 – an evidence based guideline. Clinical Microbiology and Infection. 27:61–66.

Soemarwoto RA., Marlina N., Mustofa S., Sinaga F., Gozali A., Dwi R, Hapsari TK. (2020). Clinical Characteristics of COVID-19 Pneumonia Patients in Abdoel Moeloek Regional Public Hospital, Bandar Lampung, Indonesia. JK Unila. 4(1):1-11

Soni M., Gopalakrishnan R., Vaishya R., Prabu P. (2020). D-dimer level is a useful predictor for mortality in patients with COVID-19: Analysis of 483 cases. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 14(6):2245–2249.

Surendra H., Elyazar IR., Djaafara BA., Ekawati LL., Saraswati K., Adrian V., et al. (2021). Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study. The Lancet Regional Health - Western Pacific. 9:100108

Susilo A., Martin RC., Pitoyo CW., Djoko SW., Yulianti M., Sinto R., et al. (2020). Coronavirus Disease 2019: Tinjauan Pustaka. Jurnal Penyakit Dalam Indonesia. 7;1:45-67

Tetaj N., Capone A., Stazi, GV., Marini MC., Garotto G., Busso D., et al. (2022). Epidemiology of ventilator-associated pneumonia in ICU COVID-19 patients: an alarming high rate of multidrug-resistant bacteria. Journal of Anesthesia, Analgesia and Critical Care. 2: 36.

Zaragoza R., Vidal-Cortés P., Aguilar G., Borges M., Diaz E., Ferrer R., et al. (2020). Update of the treatment of nosocomial pneumonia in the ICU. Critical Care. 24:383

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