Research has been carried out on submicroparticles of chitosan and sodium alginate as captopril carriers. This study aims to overcome the problem of permeability and improve the absorption of a macromolecular compound. Captopril preparation into submicroparticles with chitosan adsorption polymer, sodium alginate and CaCl2 crosslinking by ionic gelation method can improve the permeability problem of captopril. The concentration of chitosan which was varied against the three formulas was 0.1%; 0.2% and 0.3% resulted in the percent entrapment efficiency (EE) of 69.69% ± 0.292, 76.86% ± 0.535, and 79.26% ± 0.178, respectively. The results of the submicroparticle characterization of each formula such as diameter, particle distribution (PDI) and zeta potential using a particle size analyzer (PSA) were 232.0 nm; 0.259; -29.1 mV (F1), 333.8 nm; 0.290; +32.4 mV (F2), and 426.3 nm; 0.321; +55.6 mV (F3). The best captopril submicro particle formula was achieved in formula 3 (chitosan 0.3%). The polymer concentration has an important influence on the percent entrapment efficiency (EE), particle size, particle distribution, and the zeta potential of the captopril submicroparticles.
Berne, B. J., & Pecora, R. (2000). Dynamic Light Scattering : with application to chemistry, biology and physic. New York , Dover Publications.
Dwilistiana, N. (2019). Optimasi Formula Intranasal Nanopartikel Kitosan Pembawa Fenobarbital Dengan Variasi Jenis Crosslinker, Watu Sonikasi, dan Watu Pengadukan. Skripsi, Sarjana Farmasi, Fakultas MIPA, Universitas Sriwijaya. Indralaya.
Gopinath, H., Koteswararao, P., & Debjit, B. D. S. (2014). Formulation and Evaluation Of Captopril Microencapsules : a Sustained Release Approach. Elixir Internationan Journal, 75, 27362-27366.
Gulati, N., Naigaich, U., & Saraf, S. A. (2013). Intranasal Delivery Of Chitosan Nanoparticles For Migraine Therapy. Scientia Pharmaceutica, 81(1), 843-854.
Ismail, Isriany., Hasriani., & Surya Ningsih. (2014). Formulasi dan Karakterisasi Nanokapsul Asiklovir Tersalut Kitosan-Alginat yang Dipaut Silang dengan Natrium Tripolifosfat. Jurusan Farmasi Falkultas Ilmu Kesehatan Universitas Islam Negeri Alauddin Makasar, 2(4), 138-143.
Kafshgari, M. H., Khorram, M., Khodadoost, M., & Khawari, S. (2011). Reinforcement Of Chitosan Nanoparticles Obtained By An Ionic Cross-Linking Process. Iranian Polymer Journal, 20(5), 445-456.
Manivannan, R., & Jayalakshmi, R. (2017). Formulation And In-Vitro Evaluation Of Captopril Microspheres Using Different Polymers. International Journal of Biological and Pharmaceutical Research, 8(3): 112-116. DOI: http://dx.doi.org/10.21276/ijbpr.2017.8.3.4.
Mardiyanto, Herlina, Fithri, N. A., & Rahmi, Y. (2019). Formulasi dan Evaluasi Sediaan Submikro Partikel Gelasi-Ionik Pembawa Ekstrak Daun Pluchea indica sebagai Antibakteri pada Kulit Tikus Putih Jantan Galur Wistart. Jurnal Sains Farmasi & Klinis 6(2) ,171–179, DOI : 10.25077/jsfk.6.2.171-179.2019.
Mardliyati, E., Muttaqien, S. E., & Setyawati, D. R. (2012). Sintesis Nanopartikel Kitosan-Trypoly phosphate Dengan Metode Gelasi Ionik: Pengaruh Konsentrasi dan Rasio Volume Terhadap Karakteristik Partikel. Prosiding Pertemuan Ilmiah Ilmu Pengetahuan dan Teknologi Bahan 2012, 90-93.
Modi, J., Garima, J., & Krutika, S. (2013). chitosan Based Mucoadhesive Nanoparticles of Ketoconazole for Bioavailability Enhancement : Formulation, Optimazation, In Vitro and Ex Vivo Evaluation. Drug Development and Industrial Pharmacy, 39(4), 540-547.
Mohanraj, V. J., & Chen, Y. (2006). Nanoparticles: A Review. Tropical Journal of Pharmaceutical Research, 5 (1): 561-573.
Moradhaseli, S., Mirakabadi, A. Z., Sarzaeem, A., Dounighi, N. M., Soheily, S., & Borumand, M. R. (2013). Preparation and Characterization of Sodium Alginate Nanoparticles Containing ICD-85 (Venom Derived Peptides). International Journal of Innovation and Applied Studies 4 (3), 534-542.
Pal, S. L., Jana, U., Manna, P. K., Mohanta, G. P., & Manavalan, R. (2011). Nanoparticle: An overview of preparation and characterization. Journal of Applied Pharmaceutical Science, 01 (06); 2011: 228-234.
Park, K., Yeo, Y., & Swarbrick, J. (2007). Microencapsulation technology in: encyclopedia of pharmaceutical technology (3rd edition ed.). New York: Informa Healthcare Inc.
Perumandla, P., & Priya, S. (2014). formulation And In Vitro Evaluation Of Floating Microspheres Of Dextromethorphan Hydrobromide. International Journal Of Pharmacy And Pharmaceutical Science, 6, 206-210.
Prasetyo,Y.G., Abdassah, M., & Rusdiana, T. (2019). Preparation and Characterization of Glucosamine Nanoparticle by Ionic Gelation Method Using Chitosan and Alginat. Indonesia Journal of Pharmaceutics, 1 (1), 1-10
Selvaraj, S.,Saravanakumar, N., Karthikeyan, J., Deborah, E. D., Lathamary., & Rajendran, N. N. (2010). Acyclovir Loaded Chitosan Nanoparticles For Ocular Delivery. Der Pharmacia Lettre, 2(3), 420-431.
Soheyla, H and Foruhe, Z. (2013). Effect of Zeta Potential on the Ptoperties of Nano-Drug Delivery Systems. Tropical Journal of Pharmaceutical Research, 12(2), 265-273.
Taurina, W., Ronny, M., & Hilda, I. (2013). Preparasi Nanopartikel Gamavuto-0 Menggunakan Kitosan Rantai Pendek dan Tripolifosfat sebagai Cross Linker. Jurnal Ilmiah Farmasi, 10 (2), 1-9
Tjay, T. H., & Rahardja, K. (2007). Obat-Obat Penting: Khasiat, Penggunaan Dan Efek-Efek Sampingnya. Jakarta : Elex Media Komputindo.
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.