Identification Retinoic Acid Content in Online Whitening Cream Sold in Samarinda City Using Thin Layer Chromatography (TLC) and Spectrophotometry UV-Visible Methods
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Keywords

Whitening creams
retinoic acid
Thin Layer Chromatocraphy (TLC)
UV spectrophotometric

How to Cite

Leswana, N., & Sinaga, C. (2022). Identification Retinoic Acid Content in Online Whitening Cream Sold in Samarinda City Using Thin Layer Chromatography (TLC) and Spectrophotometry UV-Visible Methods. Journal of Pharmaceutical And Sciences, 5(2), 174-180. https://doi.org/10.36490/journal-jps.com.v5i2.112
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Abstract

Whitening creams are cosmetic preparations that are very often traded in the market because they are able to reduce skin brightness and black spot on the face. Whitening creams can contain chemicals that are harmful to the skin, such as, mercury, hydroquinone, and retinoic acid. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, and teratogenic (defects in the fetus) skin. The purpose of this study was to identify whether the whitening creams traded online in Samarinda City contained retinoic acid and to determine the level of retinoic acid in the face whitening cream. The samples studied were 5 samples each of sample A, sample B, sample C, sample D, and sample E. Qualitative analysis was carried out by the thin layer chromatography method using the n-hexane-acetone (6:4) and observed under 254 nm UV light. Based on qualitative analysis, sample B and Sample D were positive containing retinoic acid with rf values of sample B (Rf 0.48), sample D (Rf 0.47). The results of quantitative analysis using UV Visible spectrophotometry showed that all five samples contained retinoic acid with levels of 0.003%-0.024%.

https://doi.org/10.36490/journal-jps.com.v5i2.112
pdf (Bahasa Indonesia)

References

Agustina, Anita S., Choiril HM., M. E. (2019). Analisa Kualitatif Asam Retinoat pada Sediaan Krim Malam di Pasar Klaten dengan Metode Kromatografi Lapis. MOTORIK Journal Kesehatan, 14(2): 136–140.

Andriyani, Vina B., (2011). Identifikasi Asam Retinoat Dalam Krim Pemutih Wajah Secara Kromatografi Lapis Tipis. Skripsi. Universitas Sumatra Utara. Medan

Anggraeni, V. J., Yuliantini, A., Rahmawati, F., Farmakokimia, R., Tinggi, S., & Bandung, F. (2018). Analisis Cemaran Logam Berat Merkuri dalam Krim Pemutih Wajah yang Beredar di Pasar Tradisional dengan Metode Spektrofotometri Serapan Atom. Journal of Pharmacopolium, 1(1): 44–50.

BPOM RI. (2011). Peraturan Kepala Badan Pengawas Obat dan Makanan (BPOM) Republik Indonesia tentang Metode Analisis Kosmetika. Jakarta

BPOM RI. (2008). Bahan berbahaya dalam kosmetik. In: kosmetik pemutih (Whitening), naturakos, 3(8)

Hadriyati, A., Hartesi, B., & Fitri, S. (2021). Analisis Asam Retinoat Pada Krim Pemutih Malam Yang Beredar Di Klinik Kecantikan Kota Jambi Pada Kecamatan Jelutung. Media Farmasi: Jurnal Ilmu Farmasi, 17(1): 1-12

Ikawati, Z. (2010) Cerdas Mengenali Obat. Kanisius, Yogyakarta, 70-72.

Nursidika, P., Sugihartina, G., dan Fransiska, I. (2018). Asam retinoat dalam krim pemutih yang dijual secara online. Prosiding Pertemuan Ilmiah Nasional Penelitian & Pengabdian Masyarakat (PINLITAMAS 1) STIKES Jenderal Achmad Yani Cimahi, Oktober 2018. 1(1): 622–627.

Parengkuan, K., Fatimawali, Citraningtyas, G. (2013). Analisis kandungan merkuri pada krim pemutih yang beredar di Kota Manado. Pharmacon jurnal ilmiah farmasi. 2(1): 62-68

Rahman, H., Wilantika, I., Latief M. (2019). Analisis Kandungan Merkuri pada Krim Pemutih Ilegal di Kecamatan Pasar Kota Jambi Menggunakan Spektrofotometri Serapan Atom (SSA). Jurnal Farmasi Indonesia, 16(1): 59-73

Suhartini, S., Fatimawali., G. C. (2013). Analisis asam retinoat pada kosmetik krim pemutih yang beredar di pasaran kota Manado. Jurnal Ilmiah Farmasi, 2(1): 1-7.

Wardana, F. Y., Lestari, Y.S., Aprilianti, R. G. (2022). Analisis Kadar Asam Retinoat dalam Krim Pemutih Malam di Kota Malang. Jurnal Kefarmasian dan Gizi, 1(2): 58-68

Wardhani, Y. K., Styawan, A. A., dan Mustofa, C. H. (2019). Analisis Kandungan Asam Retinoat Pada Sediaan Krim Malam Yang Beredar Di Toko X Kota Klaten Dengan Spektrofotometri UV-Vis. CERATA Jurnal Ilmu Farmasi, 10(2): 61-66.

Yulianti, E., Adelsa, A., & Putri, A. (2015). The Determination of SPF (Sun Protection Factor) Value of 70 % Ethanol Extract Curcuma Mangga and 70 % Ethanol Extract Curcuma Mangga Cream In Vitro using Spektrofotometry Method, 2: 41– 50.

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